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Jinyong Wang, Ph.D., joined GIBH in 2012 as a principle investigator (Full Professor), member of 100-talents Program of Chinese Academy of Sciences. Dr. Wang obtained his doctoral degree at Zhejiang University, China. He successively took postdoctoral training at Medical College of Wisconsin, and University of Wisconsin-Madison. His research focus on regulation of hematopoiesis during normal and disease conditions. Dr. Wang is currently a member of American Society of Hematology.
Lab Members （updated Feb 2017）:
Jinyong Wang, PI
Juan Du, Associate Investigator
Qianhao Zhao, Post Doc
Xiaofei Liu, Flow Specialist
Yang Geng, Lab Manager
Dan Yang, Research Assistant
Lijuan Liu, Research Assistant
Dong Yong, Graduate student
Tongjie Wang, Graduate student
Xuejia Li, Graduate student
Rongqun Guo, Graduate student
Mengyun Zhang, Graduate student
Fangxiao Hu, Graduate student
Chengxiang Xia, Graduate student
Peiqing Zhou, Graduate student
Ying Wang, Graduate student
Cui Lv, Graduate student
Qitong Weng, Graduate student
Among the cells in hematopoietic hierarchy, hematopoietic stem cell (HSC) is the only cell type that can self-renew and generate lifelong supply of all the mature blood cells that maintain the whole hematopoietic system. Understanding of the mechanisms regulating self-renewal, differentiation of HSC is crucial for HSC maintenance, expansion and regeneration. Using in vitro differentiation and animal models, our lab focus on the regulation of hematopoiesis during stress and pathological conditions with emphasis on the role of transcription factors. Besides, the interaction between HSCs and their niches(microenvironment) is also investigated with animal models of hematopoietic malignancies.
1. Xuejia Li, Chengxiang Xia, Tongjie Wang, Lijuan Liu, Qianhao Zhao, Dan yang, Fangxiao Hu, Mengyun Zhang, Ke Huang, Yang Geng, Yi Zheng, Yuxian, Guan, Hongling Wu, Xiaoli Chen, Guangjin Pan, Jiekai Chen, Juan Du, Jinyong Wang.Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Research. 2017 Mar 21; 21:32-39.
2. Tongjie Wang, Chen Li, Chengxiang Xia, Yong Dong, Dan Yang, Yang Geng, Jizhen Cai, Jing Zhang, Xiangzhong Zhang, Jinyong Wang. Oncogenic NRAS hyper-activates multiple pathways in human cord blood stem/progenitor cells and promotes myelomonocytic proliferation in vivo. Am J Transl Res, 2015;7(10):1963-1973.
3. Xiaoli Chen, Qianhao Zhao, Chen Li, Yang Geng, Ke Huang, Jian Zhang, Xiaoshan Wang, Jiaqi Yang, Tongjie Wang, Chengxiang Xia, Xiaofei Liu, Minghui Meng, Dan Yang, Yi Zheng, Juan Du, Xiangzhong Zhang, Jiekai Chen, Guangjin Pan, Jinyong Wang. OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo. Stem Cell Research, 2015 Sep;15(2):395-402.
4. Dan Yang, Xiangzhong Zhang, Yong Dong, Xiaofei Liu, Tongjie Wang, Xiaoshan Wang, Yang Geng, Shumin Fang, Yi Zheng, Xiaoli Chen, Jiekai Chen, Guangjin Pan, Jinyong Wang. Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo. Cell Cycle, 2015; 14(4) 612-620.
5. Jinyong Wang, Guangyao Kong, Yangang Liu, Juan Du, Yuan-I Chang, Xinmin Zhang, Erik A. Ranheim, Marc K. Saba-El-Leil, Sylvain Meloche, Alisa Damnernsawad, Jingfang Zhang, Jing Zhang. NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood. 2013; 121(26):5203-5207.
6. Jinyong Wang, Yangang Liu, Zeyang Li, Zhongde Wang, Li Xuan Tan, Myung-Jeom Ryu, Benjamin Meline, Juan Du, Ken H Young, Erik Ranheim, Qiang Chang, and Jing Zhang. Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood, 2011; 118(2) 368-379.
7. Jinyong Wang, Yangang Liu, Zeyang Li, Juan Du, Myung-Jeom Ryu, Philip Taylor, Mark D. Fleming, Ken H. Young, Henry Pitot, Jing Zhang. Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood, 2010; 116(26): 5991-6002.
8. Juan Du, Jinyong Wang, Guangyao Kong, Jing Jiang, Jingfang Zhang, Yangang Liu, Wei Tong, Jing Zhang*. Signaling profiling at the single-cell level identifies a distinct signaling signature in murine hematopoietic stem cells. Stem Cells, 2012; 30(7): 1447-1454.
9. Jinyong Wang, Yangang Liu, Li Xuan Tan, Juinn Cherng Lo, Juan Du, Myung-Jeom Ryu, Erik A. Ranheim, Jing Zhang. Distinct requirements of hematopoietic stem cell activity and Nras G12D signaling in different cell types during leukemogenesis. Cell Cycle, 2011; 10(17), 1-4.