Zheng's Laboratory

Hui Zheng, Ph.D.

Dr. Zheng, a Principle Investigator at Guangzhou Institutes of Biomedicine and Health of Chinese Academy of Sciences, was born in September, 1983 in Wuhu, Anhui Province. 2001.09~2005.07, he studied in Tsinghua University. He got his Ph.D. degree in Department of Pharmacology University of Minnesota in 2010. After one year postdoctoral training, he joined the GIBH at the end of 2010.
His research was focused on neuroscience and stem cell biology. 1) The differentiation and trans-differentiation related to neural stem cells and neurons both in vitro and in vivo; 2) adult neurogenesis in SGZ in hippocampus and the contextual learning and memory; 3) Cellular and molecular mechanisms related to the induced pluripotent stem cells and embryonic stem cells, especially their differentiation potential to neurons. 4) G protein-coupled receptor in central never system.
He has published seven manuscripts in PNAS, JNS, JBC etc., as corresponding author since 2008.

Personnel: 
Currently have three research assistants and four students in the lab.

Research:
Primary cultures from rat hippocampal neurons were treated with PBS (control) for 3 d.



Publications:

1.	Zheng, H., Chu, J., Zhang, Y., Loh, H. H. & Law, P. Y. (2011) Modulating micro-opioid receptor phosphorylation switches agonist-dependent signaling as reflected in PKCepsilon activation and dendritic spine stability J Biol Chem 286, 12724-33.
2.	Zheng, H., Chu, J., Zeng, Y., Loh, H. H. & Law, P. Y. (2010) Yin Yang 1 phosphorylation contributes to the differential effects of mu-opioid receptor agonists on microRNA-190 expression J Biol Chem 285, 21994-2002.
3.	Zheng, H., Loh, H. H. & Law, P. Y. (2010) Agonist-selective signaling of G protein-coupled receptor: Mechanisms and implications IUBMB Life 62, 112-119td>
4.	Zheng, H., Zeng, Y., Chu, J., Kam, A. Y., Loh, H. H., et al. (2010) Modulations of NeuroD activity contribute to the differential effects of morphine and fentanyl on dendritic spine stability J Neurosci 30, 8102-10.
5.	Zheng, H., Zeng, Y., Zhang, X., Chu, J., Loh, H. H., et al. (2010) {micro}-Opioid Receptor Agonists Differentially Regulate the Expression of miR-190 and NeuroD Mol Pharmacol 77, 102-109.
6.	Zheng, H., Chu, J., Qiu, Y., Loh, H. H. & Law, P. Y. (2008) Agonist-selective signaling is determined by the receptor location within the membrane domains Proc Natl Acad Sci U S A 105, 9421-6.
7.	Zheng, H., Loh, H. H. & Law, P. Y. (2008) {beta}-Arrestin-Dependent {micro}-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation Mol Pharmacol 73, 178-90.
8.	Chu, J., Zheng, H., Loh, H. H. & Law, P. Y. (2008) Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins Cell Signal 20, 1616-24.
9.	Chu, J., Zheng, H., Zhang, Y., Loh, H. H. & Law, P. Y. (2010) Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization Cell Signal 22, 684-96.
10.	Pan, G., Li, J., Zhou, Y., Zheng, H. & Pei, D. (2006) A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal Faseb J 20, 1730-2.