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Shu's Laboratory

Xiaodong Shu, Ph.D.
Principal Investigator,
Key Laboratory of Regenerative Biology

1989-1993  Fudan University, B. Sc
1993-1996  Peking University, M. Sc
1996-2002  University of Southern California, Ph. D.
2002-2007  University of California, Los Angeles, Postdoc


We study the mechanism of organ formation (mainly endoderm-derived organs) in the zebrafish model. Currently we are working on:
(1) Molecular mechanism of liver/pancreas development;
(2) Hepatocyte fate determination and targeted differentiation to hepatocyte in vivo and in vitro;
(3) Mechanism of cilium formation and its role during organogenesis (left-right patterning, hair cell development etc.).

1. L. Xu, W. Yin, J. Xia, M. Peng, S. Li, S. Lin, A. Pei*, X. Shu*, An anti-apoptotic role of SNX7 is required for liver development in zebrafish. Hepatology. 2011 Dec 27. doi: 10.1002/hep.25560.
2. Y. Chen, B. Wu, L. Xu, H. Li, J. Xia, W. Yin, Z. Li, D. Shi, S. Li, S. Lin, X. Shu*, D. Pei*, A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo. Cell Res. 2012 Feb;22(2):333-45.
3. X. Shu, J. Huang, Y. Dong, J. Choi, A. Langenbacher, J. N. Chen, Na,K-ATPase alpha2 and Ncx4a regulate zebrafish left-right patterning. Development. 2007 May;134(10):1921-30.
4. E. Cibrian-Uhalte, A. Langenbacher, X. Shu, J. N. Chen, S. Abdelilah-Seyfried, Involvement of zebrafish Na+,K+ ATPase in myocardial cell junction maintenance. J Cell Biol. 2007 Jan 15;176(2):223-30.
5. A. D. Langenbacher, Y. Dong, X. Shu, J. Choi, D. A. Nicoll, J. I. Goldhaber, K. D. Philipson, J. N. Chen, Mutation in sodium-calcium exchanger 1 (NCX1) causes cardiac fibrillation in zebrafish. Proc Natl Acad Sci U S A . 2005 Dec 6;102(49):17699-704.
6. X. Shu, K. Cheng, N. Patel, F. Chen, E. Joseph, H. J. Tsai, J. N. Chen, Na,K-ATPase is essential for embryonic heart development in the zebrafish. Development. 2003 Dec;130(25):6165-73.
7. W. Wu, X. Shu, H. Hovsepyan, R. D. Mosteller, D. Broek, VEGF receptor expression and signaling in human bladder tumors. Oncogene . 2003 May 29;22(22):3361-70.
8. X. Shu, W. Wu, R. D. Mosteller, D. Broek, Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol Cell Biol. 2002 Nov;22(22):7758-68.
9. B. Das, X. Shu, G. J. Day, J. Han, U. M. Krishna, J. R. Falck, D. Broek, Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding. J Biol Chem. 2000 May 19;275(20):15074-81.
10. J. Han, K. Luby-Phelps, B. Das, X. Shu, Y. Xia, R. D. Mosteller, U. M. Krishna, J. R. Falck, M. A. White, D. Broek, Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav. Science. 1998 Jan 23;279(5350):558-60.

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