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Nov 29, 2021Scientists reveal a progressive modification mode of heterochromatin relaxation by kinaseCompared with somatic cells, pluripotent stem cells have an open chromatin state and less heterochromatin. The transition between heterochromatin and euchromatin is the key in cell fate determination, including somatic cell reprogramming... -
Oct 29, 2021A novel model of phase separation deriving mitochondrial genome assembly and transcriptionMitochondria are the powerhouse of mammalian cells, which also play critical roles in cell metabolism, cell signal and apoptosis. They are the only organelles containing own DNA, which is compacted into a special sub-organelle as nucleoi... -
Jul 21, 2021Research team led by Xu Yong at GIBH has made new progress on anti-prostate cancer drugs targeting on the new target RORγProstate cancer (PCa) is the most common malignancy and the fifth leading cause of death from malignancy in men. AR signaling pathway plays an important role in the occurrence and development of prostate cancer. AR gene amplification, mu... -
Mar 04, 2021RNA m6A Reader YTHDC1 Governs Heterochromatin FormationIn a study published in Nature, a research group led by CHEN Jiekai from Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences discovered that RNA m6A reader YT521-B homology-domain-containing protein 1 (YTHDC1... -
Feb 03, 2021Treating HBV-related HCC by affinity-improved-TCR-TThe T-cell receptor engineered T cell therapy (TCR-T) is becoming a promising treatment for cancer, with many TCR-T clinical trials being carried out for treating solid tumors. TCR-T cells engineered with a wild-type TCR, whose natural a... -
Jan 21, 2021New Mechanism of HSC Homeostasis Regulation RevealedWang Jinyong's research team from the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, and Cheng Hui/Cheng Tao's research team from the State Key Laboratory of Experimental Hematology, Institute of Hematology,...