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Aug 25, 2020Scientists Reveal an epigenome-metabolome-epigenome signalling cascade mediated by Glis1 facilitating pluripotency inductionOn August 24, Nature Metabolism journal published a latest research titled “Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade” from Xingguo Liu’s group in Guangzhou Institute of Bio... -
Aug 18, 2020Scientists discovered the mechanism of female infertility caused by mitochondrial DNA mutations and its reversal strategiesOn August 3, Aging Cell journal published a latest research titled “Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox” from Xingguo Liu’s research group in Guangzhou Institute of bi... -
Jul 20, 2020Researchers found a new transcriptional mechanism regulating mouse ground state pluripotencyMouse embryonic stem cells (ESCs) cultured with MEK and GSK3 inhibitors [2i (PD0325901 and CHIR99021) plus LIF, 2iL] more closely resemble the inner cell mass of preimplantation blastocysts than those cultured in SL (serum plus LIF).Alth... -
Jun 30, 2020Structural study reveals the molecular basis of SNX11-mediated endo-lysosomal sortingPhosphorylated phosphoinositides (PIPs) are phospholipids located at specific cellular membranes. Different phosphorylated PIs can be specifically recognized by their effectors, which will then be recruited to PI-enriched membranes. Phos... -
Jun 11, 2020Study Finds R-loops Coordinate with SOX2 in Regulating Reprogramming to PluripotencyR-loops are unique structures in the cell, composed of RNA–DNA hybrids and a displaced single-stranded DNA, that are commonly found in around transcribed genes. However, R-loops are also dynamic and widespread entities that play unclear... -
May 13, 2020Novel system reveals the mechanisms of pluripotency transitionIn a study published online in Nature Cell Biology on May 11, scientists from Guangzhou Institute of Biomedicine and Health (GIBH) of the Chinese Academy of Sciences established a novel and efficient system for non-integrated mouse Prime...