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Tao Peng, Ph.D.
Principal Investigator


Graduated from University of Pennsylvania with Ph.D.in Virology, Dr.Peng received his postdoctoral training at The Scripps Research Institute (TSRI) and University of California-San Diego. He subsequently worked as Scientist at Biotech/Biopharmaceutical companies. He joined GIBH in 2004 as a Principal Investigator and established Laboratory of Viral Immunology. He is an enlisted scientist for “Hundred Talents Programme” of Chinese Academy of Sciences. Focusing on researches related to viral infectious diseases, Dr. Peng’s group is interested in the development of antiviral and novel rapid virus detection methods.Dr. Peng is serving on the Editorial Board of Antiviral Research, an official publication of the International Society for Antiviral Research. He is the Chief Editor of “Isothermal Nucleic Acid Amplification Technology and Application”. Through the understanding of virus-host interactions and the mechanisms of pathology, the goal of their research is to discover new drug targets and to develop novel cell-based/molecular assays. Currently, his lab is performing studies on: antiviral screening and mechanism analysis; molecular mechanisms of virus entry; rapid virus detection method. Dr.Peng is the Chief Editor of “Isothermal Nucleic Acid Amplification Technology and Application”. He is also an author of “Molecular Gene Medicine” and “Platform Technologies in New Drug Discovery”. He is the inventor of “Rapid Isothermal Nucleic Acid Detection and Amplification” (RIDA) technology. He is also the inventor of more than 10 patents/patent-applications, including the US patent “Soluble Herpesvirus Glycoprotein Complex Vaccine”. Dr. Peng is an adjunct Professor, University of Science and Technology of China.

Personnel: 


Research:
Our research interest is to better understand the molecular mechanisms of virus infection and pathogenesis, through the studies of virus-host interaction. The goal of our research is to discover drug targets and biomarkers for viral infectious diseases, and thus to develop antivirals and rapid diagnostic methods. Current researches include:
1. Development of cell-based assays for the screening of virus entry inhibitors;
2. Virus infection and Golgi membrane protein;
3. Development of rapid diagnostic methods for viral infectious diseases.

Publications:
1. Hongling Wu, Ting Li, Musheng Zeng and Tao Peng “Herpes simplex virus type 1 infection activates the Epstein–Barr virus replicative cycle via a CREB-dependent mechanism” Cellular Microbiology, Dec 2011 22. doi: 10.1111/j.1462-5822.2011.01740.x.
2. Qin-Chang Zhu,, Yi Wang, Ya-Ping Liu, Rui-Qi Zhang, Xiang Li, Wen-Han Su, Fei Long, Xiao-Dong Luo,*, Tao Peng,* Inhibition of Enterovirus 71 Replication by Chrysosplenetin and Penduletin. Journal of European Pharmaceutical Sciences 2011 (Accepted).
3. Yi Wang, Qi Wang, Qinchang Zhu, Rong Zhou, Jinsong Liu*, Tao Peng* Identification and Characterization of Acyclovir-resistant Clinical HSV-1 Isolates from Children. Journal of Clinical Virology 2011, doi:10.1016/j.jcv.2011.06.009.
4. Jian Xie, Pengwei Zhang, Chuanjiang Li, Qianhua Huang, Rong Zhou, Tao Peng* Mechanistic Insights into the Roles of Three Linked Single-Stranded Template Binding Residues of MMLV Reverse Transcriptase in Misincorporation and Mispair Extension Fidelity of DNA Synthesis. Gene 2011, Jun 15;479(1-2):47-56.
5. Ruiqi Zhang, Xia Rong, Weiqi Pan, Tao Peng* Determination of Sera Neutralization Antibodies Against the Seasonal Strain H3N2 and the Emerging Strains 2009 H1N1 and Avian H5N1 Scandinavian Journal of Infectious Diseases 2011. Mar;43(3):216-20.
6. Tao Peng*. Strategies for Antiviral Screening Targeting Early Steps of Virus Infection. Virologica Sinica 2010 Vol.4:281-293.
7. Fangfang Zhang, Yanli Gu, Xiang Li, Wei Wang, Jianxing He*, Tao Peng* Up-regulated Golgi Phosphoprotein 2 (GOLPH2) Expression in Lung Adenocarcinoma Tissue. Clinical Biochemistry 2010 Aug;43(12):983-91.
8. Qin-Chang Zhu, Yi Wang and Tao Peng* Herpes Simplex Virus (HSV) Immediate-Early (IE) Promoter-Directed Reporter System for the Screening of Antiherpetics Targeting the Early Stage of HSV Infection. Journal of Biomolecular Screening 2010. Sep;15(8):1016-20.
9. Yan Zhou, Leike Li, Longbo Hu, Tao Peng* Golgi phosphoprotein 2 (GOLPH2/GP73/GOLM1) interacts with secretory clusterin. 2010 Mol Biol Rep. Mar;38(3):1457-62.
10. Yanli Gu, Wenli Chen, Yu Zhao, Liyun Chen and Tao Peng*. Quantitative Analysis of Elevated Serum Golgi Protein-73 Expression in Patients with Liver Diseases. Ann Clin Biochem 2009; 46: 38–43.
11. Wenjuan Gao, Xiang Li, Lingwen Zeng and Tao Peng*. Rapid isothermal detection assay: a probe amplification method for the detection of nucleic acids. Diag Microbiol Infect Dis. 2008, 60: 133-141.
12. Xiang Li and Tao Peng*. A New Rapid Isothermal Nucleic Acid Detection Method. Chinese Journal of Laboratory Medicine, 2008 Vol. 31, No.3 322-324.
13. Hongbin Xie, Yu Gong and Tao Peng*. Cloning of the Promoter Regions of Golgi Membrane Glycoprotein GP73. Agricultural Science and Technology. 2008 Vol. 9, No.3.
14. Qiwei Zhang, Xiaobo Su, Gong S, Zeng Q, Zhu B, Wu Z, Tao Peng, Zhang C, Zhou R. Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China. Journal of General Virology. 2006 87(Pt 6):1531-41.
15. Hengli Tang, Tao Peng and Flossie Wong-Staal Novel technologies for studying virus-host interaction and discovering new drug targets for HCV and HIV. 2002 Current Opinion in Pharmacology 2:541-547.
16. Tao Peng*, M. J. Novotny, M. Ponce-de-Leon, H. Jiang, G. Dubin, J. Lambris, P. G. Spear, G. H. Cohen and R. J. Eisenberg 1998. Structural and Antigenic Analysis of a Truncated form of Herpes Simplex Virus Glycoprotein Complex gH-gL Complex. Journal of Virology. Vol. 72 No. 6 p6092-6103.
17. Tao Peng*, M. Ponce-de-Leon, H. Jiang, G. Dubin, J. M. Lubinski, R. J. Eisenberg and G. H. Cohen 1998. Herpes Simplex Virus Glycoprotein Complex gH-gL Stimulates a Protective Immune Response in Mice. Journal of Virology. Vol. 72 No. 1 p65-72.
18. J.C. Whitbeck, C. Peng, H. Lou, R. Xu, S.H. Willis S.H., Ponce de Leon, M., Tao Peng, A.V. Nicola, R.I. Montgomery, M.S. Warner, A.M. Soulika, L.A. Spruce, W.T. Moore, J.D. Lambris, P.G. Spear, G.H. Cohen, R.J. Eisenberg 1997. Glycoprotein D of Herpes Simplex Virus (HSV) Binds Directly to HVEM, a member of the Tumor Necrosis Factor Receptor Superfamily and a Mediator of HSV entry. Journal of Virology. 71: 6083-6093.
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