-
Jan 13, 2022B cell regeneration from pluripotent stem cellsB cells are essential for a functional and complete humoral immune system. With certain disease conditions, the B lymphopoiesis and serum immunoglobulin levels are severely impaired, resulting in infections in patients. Regeneration of a... -
Dec 20, 2021NMPA Approved the First New Drug Independently Discovered by GIBHOn November 25th, Olverembatinib developed independently by Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (referred to as GIBH hereinafter) was officially approved t by the National Medical Products Adminis... -
Nov 29, 2021Scientists reveal a progressive modification mode of heterochromatin relaxation by kinaseCompared with somatic cells, pluripotent stem cells have an open chromatin state and less heterochromatin. The transition between heterochromatin and euchromatin is the key in cell fate determination, including somatic cell reprogramming... -
Oct 29, 2021A novel model of phase separation deriving mitochondrial genome assembly and transcriptionMitochondria are the powerhouse of mammalian cells, which also play critical roles in cell metabolism, cell signal and apoptosis. They are the only organelles containing own DNA, which is compacted into a special sub-organelle as nucleoi... -
Jul 21, 2021Research team led by Xu Yong at GIBH has made new progress on anti-prostate cancer drugs targeting on the new target RORγProstate cancer (PCa) is the most common malignancy and the fifth leading cause of death from malignancy in men. AR signaling pathway plays an important role in the occurrence and development of prostate cancer. AR gene amplification, mu... -
Mar 04, 2021RNA m6A Reader YTHDC1 Governs Heterochromatin FormationIn a study published in Nature, a research group led by CHEN Jiekai from Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences discovered that RNA m6A reader YT521-B homology-domain-containing protein 1 (YTHDC1...