-
Jul 20, 2023Researchers Develop Switchable CAR-T for Tumor -associated AntigensCAR-T therapy has achieved good results in treating hematologic malignancies, but it shows limited efficacy in solid tumors. Traditional CAR-T only targets one or two antigen epitopes. However, cancer cells are prone to loss antigens, en...CAR-T therapy has achieved good results in treating hematologic malignancies, but it shows limited efficacy in solid tumors. Traditional CAR-T only targets one or two antigen epitopes. However, cancer cells are prone to loss antigens, en... -
Jul 17, 2023Research reveals conserved features between SARS-CoV-1 and SARS-CoV-2 spike proteinsIn a research article titled "Disulfide stabilization reveals conserved dynamic features between SARS-CoV-1 and SARS-CoV-2 spikes" published in Life Science Alliance, a team led by Professor XIONG Xiaoli, Professor HE Jun and Professor C...A team led by Professor XIONG Xiaoli, Professor HE Jun and Professor CHEN Ling from the Guangzhou Institutes of Biomedicine and Health of the Chinese Academy of Sciences introduced designed disulfide bonds into the SARS-CoV-1 spike (S) ... -
May 26, 2023Novel Spatial Multi-omics Technology Deciphers Spatiotemporal Lineage of Mouse Brain DevelopmentHuman and many other mammals are composed of billions of cells, which, although originating from the same fertilized egg, differ in types, developmental timing, and spatial distribution. But how are the identity and function of these cel...Human and many other mammals are composed of billions of cells, which, although originating from the same fertilized egg, differ in types, developmental timing, and spatial distribution. But how are the identity and function of these cel... -
Jan 12, 2023Researchers Develop Highly Sensitive and Specific CRISPR/Cas12a-based Detection Method for Helicobacter PyloriProf. LI Zhiyuan’s group at Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences proposed a novel method for the ultrasensitive and specific detection of the highly pathogenic helicobacter pylori (H. pylori) strai...Prof. LI Zhiyuan’s group at Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences proposed a novel method for the ultrasensitive and specific detection of the highly pathogenic helicobacter pylori (H. pylori) strai... -
Jun 06, 2022New Base Editing System Developed for Creating Saturated Mutant PopulationsRecently, LAI Liangxue’s Lab from Guangzhou Institute of Biomedicine and Health (GIBH) of Chinese Academy of Sciences (CAS) has developed a new type of dual deaminase-mediated base editing system, the AGBE system. It can widely induce m... -
Apr 20, 2022Mitolysosome Exocytosis, a Novel Mechanism Helps to Unveil Drug-induced ParkinsonismAs the second most common cause of parkinsonism following Parkinson’s disease, drug-induced parkinsonism is affecting people’s life and health particularly in an aging society. Chronic use of flunarizine (FNZ), a drug often for treatin...