As of December 31, 2019, GIBH has undertaken more than 1,220 scientific research projects of the Ministry of Science and Technology of the People’s Republic of China, the Chinese Academy of Sciences, the National Natural Science Foundation of China, and local governments; moreover, it has published 1,608 scientific papers including 1,450 SCI papers, and submitted 662 patent applications, of which there is 503 domestic patents, 99 international patents and 60 PCT applications. The total number of granted applications is 302, including 272 domestic patents and 30 international ones. The invention patent "A method for establishing a model of immunodeficiency mouse" won the 19th China Patent Excellence Award and the 4th Guangdong Patent Excellence Award; the invention patent "Integrative plasmid pOPHI and resistance screening marker-free self-luminescent mycobacterium" won the 5th Guangdong Patent Excellence Award. In total, GIBH has won 2 second prizes of National Natural Science Award, 1 Outstanding Science and Technology Achievement Prize of Chinese Academy of Sciences, 1 Nanyue Innovation Award, 3 first prizes of Guangdong Science and Technology Award, 3 first prizes of Guangzhou Science and Technology Award, 1 China Patent Excellence Award and 2 Guangdong Patent Excellence Awards.
The Ultrastructural Technology Platform comprises two essential components: the subcellular ultrastructural imaging technology platform and the single-particle protein structure analysis technology platform. Subcellular ultrastructural imaging technology platform is crucial for analyzing the ultrastructure of organelles within cells. By providing detailed insights into the organization and function of cellular components, this technology aids researchers in understanding cellular processes and their implications for health and disease. Single-particle protein structure analysis technology platform addresses the need for three-dimensional spatial structure reconstruction of biological macro-molecules. It is instrumental in structural biology, enabling researchers to visualize and analyze the intricate structures of proteins at the atomic level.
The Cell Identification Technology Platform comprises two essential components: the optical imaging technology platform and the flow cytometry analysis/sorting technology platform. This Platform is indeed a vital resource for researchers in various fields, including cell biology, biomedicine, and health. This platform facilitates both quantitative and qualitative analyses of cellular functions and phenotypic characteristics, providing insights that are crucial for understanding cellular behavior and interactions.
Physical and Chemical Analysis Technology Platform
The Physical and Chemical Analysis Technology Platform offers analysis and identification of biological molecules ranging from small to macro molecules, along with structural and functional analysis. It plays a vital role in research endeavors aimed at discovering biomarkers, identifying drug targets, and uncovering the mechanisms of life activities.
The Conventional Support Technology Platform, equipped with 38 life science laboratory instruments, serves as a versatile resource for a wide range of experimental applications, such as sample separation and purification, gene expression analysis, high-throughput screening, and radiation biology research.
The Model Animal Technology Platform is dedicated to providing a comprehensive suite of technical services pertinent to animal experimentation, including but not limited to animal care and management, the establishment of disease models, conservation and reproduction, embryo cryopreservation, and biological cleaning. We implement rigorous scientific management and judicious utilization of laboratory animal resources to ensure that both species conservation and the analysis and evaluation of animal models are effectively conducted. Moreover, through the development of the laboratory animal information management system, we have achieved seamless full-cycle management of experimental processes.
This platform is furnished with advanced equipment for six major functionalities including genetics, viruses, bacteria, parasites, clinical laboratory tests and environmental tests, and is capable of providing relevant detection and technical services in accordance with the national standard or industrial standard.
The platform can be used for ethological evaluation to conduct pharmacological research on neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, depression, behavioral evaluation of transgenic and gene knockout animal models, and behavioral research on novel animal resources.
For clinical medicine and disease diagnosis, prevention, treatment, drug research and development and safety evaluation biomedical provide important theory and technical support.
The ADME/T/PK/PD system platform is a preclinical drug evaluation platform integrating pharmacokinetic, pharmacodynamic and toxicological evaluation services.
Guangzhou Branch of the Supercomputing Center of CAS
1.To provide computational support and service assurance for the field of biomedicine and health. 2.To become a training base for talents in high-performance computing applications in biomedicine
A GMP production workshop, a standardized cell testing laboratory platform, a programmable cooling system, and a CellSOAP cell cryopreservation management system.
Established in 2009, the Mouse Chimeric Platform has developed robust methodologies for evaluating stem cell pluripotency, catalyzing groundbreaking research and publications in iPSC biology
SCTL successfully obtained accreditation from the China National Accreditation Service for Conformity Assessment (CNAS) on July 21, 2021, receiving both the CNAS accreditation mark and certificate.
Life science equipment development service platform
The platform is staffed with professional engineers specializing in bio 3D printing, research machinery, circuit control, research optical equipment, and microfluidic chip design and testing
Protein-protein interaction, protein post-translational modification site characterization, protein post-translational modification omics, protein molecular weight determination, and other analysis.
It provides high-quality, efficient technical support for RNA analyses from an RNA-omics perspective, including methods such as CLIP-seq, RIP-seq, and nascent RNA-seq.
South China Stem Cell Translational Resource Center
The laboratory primarily provides scientific, accurate, fair, and efficient standardized quality assessments for various cells or biological products with potential therapeutic applications.