-
Mar 16, 2016Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin BiosynthesisCaerulomycins (CRMs) are members of a small family of natural products containing a 2’2-bipyridyl ring core structure. CRMs have been shown to exhibit diverse bioactivities ranging from antibacterial to cytotoxic activities. In particul...
-
Mar 16, 2016Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin BiosynthesisCaerulomycins (CRMs) are members of a small family of natural products containing a 2’2-bipyridyl ring core structure. CRMs have been shown to exhibit diverse bioactivities ranging from antibacterial to cytotoxic activities. In particul...
-
Mar 15, 2016Scientists from GIBH discovered that proton channel activity of influenza A virus matrix protein 2 contributes to autophagy arrestInfluenza viruses cause significant morbidity and mortality in humans. An outstanding feature of the virus is its ability to regulate host cellular pathways for its benefit. Recent studies showed that influenza A virus perturbs the autop...
-
Mar 15, 2016Scientists from GIBH discovered that proton channel activity of influenza A virus matrix protein 2 contributes to autophagy arrestInfluenza viruses cause significant morbidity and mortality in humans. An outstanding feature of the virus is its ability to regulate host cellular pathways for its benefit. Recent studies showed that influenza A virus perturbs the autop...
-
Jan 27, 2016GIBH scientists discovered that dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cellsDuring the progression from mouse embryonic fibroblasts (MEFs) to pluripotent stem cells (iPSCs), the cell undergoes a remodeling of chromatin architecture. Nucleosomes are the fundamental structural units of chromatin, consisting of app...
-
Jan 27, 2016GIBH scientists discovered that dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cellsDuring the progression from mouse embryonic fibroblasts (MEFs) to pluripotent stem cells (iPSCs), the cell undergoes a remodeling of chromatin architecture. Nucleosomes are the fundamental structural units of chromatin, consisting of app...