Overview

Pathology technology platform is mainly responsible for pathological detection , equipped with a full set of advanced automated pathological sample preparation, slice production and image acquisition and analysis equipment, can achieve high standard, systematic histopathology technology and morphological analysis of one-stop detection services, to assist researchers to pathological observation, study the etiology, pathogenesis, morphological structure, function and metabolic changes, reveal the law of disease, for clinical medicine and disease diagnosis, prevention, treatment, drug research and development and safety evaluation biomedical provide important theory and technical support.


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Services

The pathological technology detection items of this platform include sample fixation, tissue dehydration and embedding, paraffin section making, frozen section making, routine HE staining, special staining (Masson tricolor, scarlet, PAS, NIS, solid green, oil red O, Swiss-Giemsa, etc.), immunohistochemistry, immunofluorescence, TUNEL detection, pathological section scanning of panoramic images (open field, fluorescence) and data analysis.


Resources

     Equipment Information


Name: Fully automatic tissue dehydrator 

Manufacturer: Leica Leica, Germany Model : TP1020 

Main functions and applications: the sample specimen will be automatically immersed in various solvents according to the program for dehydration, transparent and wax immersion for paraffin pretreatment.


Name: tissue embedded wax dropping machine + freezing table 

Manufacturer: Epdi Epredia + Patrick Model : Histostar + BM450 

Main functions and applications: Human or animal and plant specimens are embedded in wax, quickly frozen for slicing.

Name: glass slide machine + embedded box laser machine 

Manufacturer: Leica Leica + Guangdong Jinquan 

Model : PERMA S + JQ-EMR830 Main functions and applications: can systematize, standardize editing and mark sample organization, and speed up work efficiency.

Name: Paraffin slicer + spread machine 

Manufacturer: Leica Leica, Germany Model : RM2255, and Histocore 00107 

Main functions and applications: The microslicer is widely used in medical, biological science and pharmaceutical research fields. It can slice hard paraffin support tissue for histology, cytology, pathology, and anatomicalslices.

Name: Automatic dyeing and sealing piece integrated machine 

Manufacturer: Leica Leica, Germany Model : SPECTRA ST + CV 

Main functions and applications: The dyeing machine can complete the whole process of dewaxing, hydration, dyeing, washing, dehydration, transparency and sealing of pathological slices in one stop. It adopts intelligent reagent management, tape sealing, humanized software and reliable structural design to provide efficient, safe and stable quality pathological slices.

Name: Frozen microome 

Manufacturer: Epdi Epredia 

Model: CryoStar NX70 HOMPVD Main functions and applications: The slicer can quickly cool the tissue to a certain hardness at low temperature for slicing, and a large number of applications in animal and plant histomorphology, neuropathology, diagnosis, enzyme histochemistry, material chemistry can quickly complete the multi-slice of samples, and can also be used for 3D reconstruction analysis of multi-layer slices of samples.


Name: Panorama scanning and analysis system for ultra-high-resolution digital pathology slices 

Manufacturers: Tissue Gnostics GmbH, Austria 

Model: Tissue FAXS Plus ST 

Main function and application: Using the leading TissueFAXS Cytometry tissue cell quantitative technology, realize the slide automatic panoramic imaging and tissue quantitative analysis, in subcellular, cellular, multicellular tissue structure and other multiple levels of tissue sample marker (protein, nucleic acid, etc.), tissue cell morphology, cell spatial distribution of biological information achieved unprecedented accurate quantification. Its system sample compatibility is wide, can process HE, IHC, IF, Masson and other labeled samples, suitable for paraffin sections, frozen sections, cultured cells, TMA tissue chip and cell smear. It has been successfully applied to cancer, neurology, immunology, cardiovascular and cerebrovascular diseases, developmental biology, metabolic physiology, urology, drug research and development, and clinical diagnosis.

People
History
Acknowledging Support

The authors gratefully acknowledge support from the Pathology technology platform.

Contact

Technical Support and Communication

People：
Phone：
Email：
Address：		 LIANG Haozhao, LIN Zuoxian
+86-20-32015217
liang_haozhao@gibh.ac.cn, lin_zuoxian@gibh.ac.cn
Room H322, 190 Kaiyuan Avenue, Guangzhou Science Park, Huangpu District, Guangzhou