Overview

The core of cell lineage research lies in understanding the fundamental unit of life: the cell. The primary goal is to uncover the origins and connections of cell types, decode the molecular programs that govern how cells develop complex functions, and explore their highly dynamic properties. Just as the invention of the microscope led to the inception of "Cell Theory," contemporary lineage technologies—such as single-cell sequencing, real-time imaging, lineage tracing, and functional screening—along with automated and scalable bioengineering methodologies, are poised to incarnate modern “Cell Theory”.


The Center for Cell Lineage Technology and Engineering is dedicated to spearheading the development of cutting-edge technologies and detection equipment for cell lineage studies, with a particular focus on precise lineage programming at high-continuous time resolution and high spatial resolution. The center will engage in interdisciplinary research, develop advanced biological analytical technologies, and develop high-end equipment to propel cell lineage research forward. By doing so, it aims to transform research paradigms and foster a culture of scientific excellence and innovation, ultimately establishing itself as a world-class hub for frontier biotechnology and equipment research. 

Research Groups and Group Leader: 

• Spatial Lineage Technology Research Group (Group Leader: Guangdun Peng) 

• Lineage Automation Equipment Research Group (Group Leader: Xiao Zhang) 

• Lineage Interaction Research Group (Group Leader: Ziyuan Duan) 

• Lineage Functional Analysis Research Group (Group Leader: Yinxiong Li) 

• Lineage Regulation Technology Research Group (Group Leader: Zhiyuan Li) 

• Imaging Lineage Technology Research Group (Group Leader: Fei Sun) 

Acting Deputy Director: Guangdun Peng 

Deputy Director: Xiao Zhang


Research

The brain is a complex tissue whose function relies on coordinated anatomical and molecular features. However, the molecular annotation of the spatial organization of the brain is currently insufcient. Here, we describe microfuidic indexing-based spatial assay for transposase-accessible chromatin and RNA-sequencing (MISAR-seq), a method for spatially resolved joint profling of chromatin accessibility and gene expression. By applying MISAR-seq to the developing mouse brain, we study tissue organization and spatiotemporal regulatory logics during mouse brain development.

Resources

https://spasi.ccla.ac.cn,  Spatiotemporal orchestration of multicellular transcriptional programs and molecular signalings in spinal cord injury

http://most.ccla.ac.cn,  Spatial Transcriptomic Atlas of Mouse Embryo Development in Organogenesis

http://sop.ccla.ac.cn,  Spatial molecular anatomy of germ layers in the gastrulating Cynomolgus monkey embryo


History
Acknowledging Support

The authors gratefully acknowledge support from the Guangzhou Branch of the Supercomputingcenter of Chinese Academy of Sciences.

Contact

Technical Support and Communication

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Cheng Congcong
020-167889999
sciencedb@gibh.ac.cn
Room M101, No. 190 Kaiyuan Avenue, Guangzhou Science Park,Luogang District, Guangzhou, Guangdong Province