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2024 - Present |
Guangzhou Institutes of Biomedicine and Health at Chinese Academy of Sciences, PI |
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2019 - 2024 |
School of Life Sciences at South China Normal University, Professor |
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2017 - 2019 |
School of Life Sciences at The University of Chicago, Instructor |
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2012 - 2017 |
School of Life Sciences at The University of Chicago, Postdoctoral scholar |
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2007 - 2012 |
Zhongshan School of Medicine of Sun Yat-sen University, PhD |
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2002 - 2007 |
School of Medicine at Anhui University of Science and Technology, Bachelor |
My research interests focus on the mechanisms underlying host-microbiome interactions in physiological and pathological conditions. I received my PhD in 2012 at Sun Yat-sen University studying pathogen biology, then I finished my postdoctoral training in Prof. Tao Pan’s lab at the University of Chicago from 2012 to 2017, I was promoted to be Independent Instructor at the University of Chicago in 2017 after I received the NIH K award. I came back to China and took a full professor position at South China Normal University in 2019. In 2024, I moved to Guangzhou Institutes of Biomedicine and Health at Chinese Academy of Sciences as a Principal Investigator. I have published more than 60 papers in Nature Chemical Biology, Cell Reports, Advanced Science, Genome Research, Cell Research, Genome Biology, PLoS Genetics, etc. I am the first or corresponding author in more than 30 of these publications.
1. Funding Title: The mechanism of bile acid regulation of host RNA m6A modification to promote inflammatory bowel disease after intestinal microbiota disorder
National Natural Science Foundation of China
01/01/26-12/31/2029
2. Funding Title: Study on the role of gut microbiota in regulating host mRNA methylation
National Natural Science Foundation of China
01/01/21-12/31/2024
3. Funding Title: Study on the role of gut microbiota in regulating host tRNA methylation in mosquito
National Natural Science Foundation of China
01/01/20-12/31/2022
4. Funding Title: The role of gut microbiota metabolite folic acid in regulating mouse RNA methylation and organ development
Guangdong Natural Science Foundation of China
01/01/2022-12/31/2024
5. Funding Title: The role of gut microbiota in regulating Drosophila host mRNA m6A
Guangdong Natural Science Foundation of China
01/01/2021-12/31/2023
6. Funding Title: The role of epigenetics in host-gut microbiota interactions
Guangzhou Science and Technology Project of China
01/01/2024-12/31/2026
7. Funding Title: Regulation through gut microbiome-derived queuosine tRNA modification
NIDDK at United States National Institutes of Health
08/04/17-7/31/2019
1. Xu Z#, Zheng X#, Fan J#, Jiao Y, Huang S, Xie Y, Xu S, Lu Y, Liu A, Liu R, Yang Y, Luo GZ, Pan T, Wang X*. Microbiome-induced reprogramming in post-transcriptional landscape using Nanopore direct RNA sequencing. Cell Reports. 2024,43(10):114798.
2. Yang M#, Zheng X#, Fan J#, Cheng W#, Yan TM, Lai Y, Zhang N, Lu Y, Qi J, Huo Z, Xu Z, Huang J, Jiao Y, Liu B, Pang R, Zhong X, Huang S, Luo GZ, Lee G, Jobin C, Eren AM, Chang EB, Wei H*, Pan T*, Wang X*. Antibiotic-induced gut microbiota dysbiosis modulates host transcriptome and m6A epitranscriptome via bile acid metabolism. Advanced Science. 2024, 11(28):e2307981.
3. Huang J#, Chen W#, Zhou F, Pang Z, Wang L, Pan T, Wang X*. Tissue-specific reprogramming of host tRNA transcriptome by the microbiome. Genome Research. 2021, 31(6):947-957.
4. Wang X#, Li Y#, Chen W, Shi H, Eren AM, Morozov A, He C, Luo GZ*, Pan T*. Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome. Cell Research. 2019, 29(2):167-170.
5. Ma H#, Wang X#, Cai J#, Dai Q, Natchiar SK, Lv R, Chen K, Lu Z, Chen H, Shi YG, Lan F, Fan J, Klaholz BP, Pan T*, Shi Y*, He C*. N6-methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nature Chemical Biology. 2019, 15(1):88-94.
6. Wang X, Chen W, Huang Y, Sun J, Men J, Liu H, Luo F, Guo L, Lv X, Deng C, Zhou C, Fan Y, Li X, Huang L, Hu Y, Liang C, Hu X, Xu J, Yu X*. The draft genome of the carcinogenic human liver fluke Clonorchis sinensis. Genome Biology. 2011, 12(10):R107.
7. Liu X#, Yang M#, Liu R, Zhou F, Zhu H*, Wang X*. The impact of Parkinson's disease-associated gut microbiota on the transcriptome in Drosophila. Microbiology Spectrum. 2023 Sep 27;e0017623.
8. Huang J#, Zhou F#, Zhou H, Zheng X, Huo Z, Yang M, Xu Z, Liu R, Wang L, Wang X*. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. PNAS Nexus. 2023 Dec 5;2(12):pgad390.
9. Liu A, Huo Z, Xu Z, Liu S, Jiao Y, Li R, Lu Y, Yang M, Huang J, Huang C, Wang X*. Transcriptome-wide regulation of folate on neural mRNA m6A methylome via carbon metabolism in Drosophila and mammals. Communications Biology. 2025 Aug 4;8(1):1151.
10. Ye Tian, Wang X*. RNA modification is the mark and strategy for host-microbe interactions. Cell Mol Life Sci. 2025 Aug 8;82(1):306.