2024.02-Present Guangzhou Institutes of Biomedicine and Health at Chinese Academy of Sciences, Principal Investigator
2019.02-2024.02 School of Life Sciences at South China Normal University, Professor
2017.08-2019.02 School of Medicine at University of Chicago, Independent Instructor
2012.07-2017.07 School of Medicine at University of Chicago, Postdoctoral scholar
2007.09-2012.07 Zhongshan School of Medicine of Sun Yat-sen University, PhD
2002.09-2007.07 School of Medicine at Anhui University of Science and Technology, Bachelor
1. Gut microbiome and host interaction mechanisms
The gut microbiome is very important for human and animal health. It's considered the second genome of the human body and has been a hot research topic in recent years. This area uses multi-omics technologies (metagenomics, metabolomics, proteomics, RNA epigenomics, single-cell transcriptomics, etc.) to explore the mechanisms of interaction between the microbiome and the host.
2. Gut pathogenic bacteria and host interaction mechanisms
Pathogenic bacteria pose a serious threat to human health and public health, and many infections and pathogenic mechanisms are still unclear. This research focuses mainly on carcinogenic pathogenic bacteria (such as Helicobacter pylori, Clostridium nucleatum, Clostridioides difficile, etc.) to study how these pathogens infect hosts and cause disease, as well as strategies for prevention and control.
3. Gut probiotics and host interaction and applications
The gut microbiome plays an important role in host metabolism and immune function. This area explores the biological functions of gut probiotics and their metabolites, which have broad application prospects. The focus is mainly on how gut probiotics and microbiome-derived medicinal small molecules regulate host immune mechanisms and their potential value in disease treatment.
1. Amna Chudhary, Wang X*. Molecular mimicry and functional convergence of bacterial proteins in host-microbe interactions. Cell Reports. 2026, 45(9):117983.
2. Li J#, Liu A#, Liu R, Xu Z, Yang M, Zheng X, Tian Y, Wen S, Cao K, Lu D, Huang C, Yan TM, Wang X*. Tissue-specific mRNA m6A reprogramming unveils vitamin-driven post-transcriptional regulation in mice. Genome Research. 2026 May 11. doi: 10.1101/gr.280968.125.
3. Liu A, Huo Z, Xu Z, Liu S, Jiao Y, Li R, Lu Y, Yang M, Huang J, Huang C, Wang X*. Transcriptome-wide regulation of folate on neural mRNA m6A methylome via carbon metabolism in Drosophila and mammals. Communications Biology. 2025 Aug 4;8(1):1151.
4. Ye Tian,Wang X*. RNA modification is the mark and strategy for host-microbe interactions. Cell Mol Life Sci. 2025 Aug 8;82(1):306.
5. Xu Z#, Zheng X#, Fan J#, Jiao Y, Huang S, Xie Y, Xu S, Lu Y, Liu A, Liu R, Yang Y, Luo GZ, Pan T, Wang X*. Microbiome-induced reprogramming in post-transcriptional landscape using Nanopore direct RNA sequencing. Cell Reports. 2024,43(10):114798.
6. Yang M#, Zheng X#, Fan J#, Cheng W#, Yan TM, Lai Y, Zhang N, Lu Y, Qi J, Huo Z, Xu Z, Huang J, Jiao Y, Liu B, Pang R, Zhong X, Huang S, Luo GZ, Lee G, Jobin C, Eren AM, Chang EB, Wei H*, Pan T*, Wang X*. Antibiotic-induced gut microbiota dysbiosis modulates host transcriptome and m6A epitranscriptome via bile acid metabolism. Advanced Science. 2024, 11(28):e2307981.
7. Huang J#, Zhou F#, Zhou H, Zheng X, Huo Z, Yang M, Xu Z, Liu R, Wang L, Wang X*. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. PNAS Nexus. 2023 Dec 5;2(12):pgad390.
8. Liu X#, Yang M#, Liu R, Zhou F, Zhu H*, Wang X*. The impact of Parkinson's disease-associated gut microbiota on the transcriptome inDrosophila. Microbiol Spectr. 2023 Oct 17;11(5):e0017623.
9. Huang J#, Chen W#, Zhou F, Pang Z, Wang L, Pan T, Wang X*. Tissue-specific reprogramming of host tRNA transcriptome by the microbiome. Genome Research. 2021, 31(6):947-957.
10. Wang X#, Li Y#, Chen W, Shi H, Eren AM, Morozov A, He C, Luo GZ*, Pan T*. Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome. Cell Research. 2019, 29(2):167-170.
11. Ma H#, Wang X#, Cai J#, Dai Q, Natchiar SK, Lv R, Chen K, Lu Z, Chen H, Shi YG, Lan F, Fan J, Klaholz BP, Pan T*, Shi Y*, He C*. N6-methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nature Chemical Biology. 2019, 15(1):88-94.
12. Liu F, Clark W, Luo G, Wang X, Fu Y, Wei J, Wang X, Hao Z, Dai Q, Zheng G, Ma H, Han D, Evans M, Klungland A, Pan T*, He C*. ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell. 2016 Oct 20;167(3):816-828.
13. Wang X, Pan T*. Methionine Mistranslation Bypasses the Restraint of the Genetic Code to Generate Mutant Proteins with Distinct Activities. PLoS Genet. 2015 Dec 28;11(12):e1005745.
14. Wang X#, Chen W#, Tian Y, Mao Q, Lv X, Shang M, Li X, Yu X*, Huang Y*. Surface display ofClonorchis sinensisenolase onBacillus subtilisspores potentializes an oral vaccine candidate. Vaccine. 2014 Mar 10;32(12):1338-45.
15. Wang X, Chen W, Huang Y, Sun J, Men J, Liu H, Luo F, Guo L, Lv X, Deng C, Zhou C, Fan Y, Li X, Huang L, Hu Y, Liang C, Hu X, Xu J, Yu X*. The draft genome of the carcinogenic human liver fluke Clonorchis sinensis. Genome Biology. 2011, 12(10):R107.