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May 08, 2012Direct Carboxamidation of Indoles by Palladium-catalyzed C–H Activation and Isocyanide InsertionIndole and its derivatives are a very important class of molecules existing widely in natural products and synthetic pharmaceutical agents with a broad range of bioactivities. Therefore, continuous efforts have been paid to their synthes...
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Apr 17, 2012GIBH Discovered The Regulatory Roles Played By Cholesterol Level On Receptor FunctionsDr. Zheng’s group in GIBH has discovered that low cholesterol level can impair the signaling transduction and the in vivo functions of μ-opioid receptor in HEK cell models, primary cultures of hippocampal neurons, and in adult mice. Af...
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Apr 17, 2012GIBH Discovered The Regulatory Roles Played By Cholesterol Level On Receptor FunctionsDr. Zheng’s group in GIBH has discovered that low cholesterol level can impair the signaling transduction and the in vivo functions of µ-opioid receptor in HEK cell models, primary cultures of hippocampal neurons, and in adult mice. Af...
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Mar 02, 2012GIBH’s New Progress of Treating Non-small-cell Lung Cancer (NSCLC)Small molecular EGFR inhibitors, gefinitib and erlotinib, were approved by US Food and Drug Administration in 2002 and 2004, respectively, and have achieved significant clinical benefit for non small cell lung cancer (NSCLC) patients. Bu...
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Jan 05, 2012Vitamin C enhances the generation of mouse and human induced pluripotent stem cellsSomatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors. However, the low efficiency and slow kinetics of the reprogramming process have hampered progress with this technology. Prof Duanqing Pei’...
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Jan 05, 2012Vitamin C enhances the generation of mouse and human induced pluripotent stem cellsSomatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors. However, the low efficiency and slow kinetics of the reprogramming process have hampered progress with this technology. Prof Duanqing Pei’...