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May 31, 2016GIBH scientists successfully carry out synthesis of imidazoles from ketones and aldehydesIn recent years, transition-metal-catalyzed direct C-H bond amination/amidation has been intensively studied due to the great importance of nitrogen-containing compounds in almost all areas of chemical research. The efficient constructio...
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May 25, 2016A transition-metal-free conversion of 2-arylindoles to 2-aminoarylphenones has been developed by scientists from GIBH.Nowadays much attention has been paid to chemoselective C-C bond cleavage followed by new C-C and/or C-heteroatom bond formation; since it enables a great number of readily available substances in chemical transformations. Recently, a tr...
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May 25, 2016A transition-metal-free conversion of 2-arylindoles to 2-aminoarylphenones has been developed by scientists from GIBH.Nowadays much attention has been paid to chemoselective C-C bond cleavage followed by new C-C and/or C-heteroatom bond formation; since it enables a great number of readily available substances in chemical transformations. Recently, a tr...
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Mar 22, 2016Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activatorsRecently, a site-specific nuclease clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 system has been engineered to target and edit specific genome sites through a synthetic single-guided RNA (sg...
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Mar 22, 2016Conversion of embryonic stem cells into extraembryonic lineages by CRISPR-mediated activatorsRecently, a site-specific nuclease clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated (Cas) 9 system has been engineered to target and edit specific genome sites through a synthetic single-guided RNA (sg...
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Mar 16, 2016Biochemical and Structural Insights into the Aminotransferase CrmG in Caerulomycin BiosynthesisCaerulomycins (CRMs) are members of a small family of natural products containing a 2’2-bipyridyl ring core structure. CRMs have been shown to exhibit diverse bioactivities ranging from antibacterial to cytotoxic activities. In particul...