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Jun 13, 2025Researchers identify a PRC1.1 inhibitor for treating bone deterioration disordersIn this study, researchers discovered that the aberrant activation of PRC1.1, a non-canonical PRC1 complex, is closely linked to impaired ossification during aging. In activation of KDM2B, a core subunit of PRC1.1, significantly promoted...A recent collaborative study by the Guangzhou Institutes of Biomedicine and Health (GIBH) of the Chinese Academy of Sciences (CAS) and Tianjin Medical University has uncovered a potential therapeutic strategy for bone deterioration disor... -
Jun 13, 2025Researcher discovers caloric restriction triggers neurodegeneration with mitochondrial DNA depletion by altering ER-mitochondria calcium transferThe team revealed that CR induces neurodegeneration in neurons with mitochondrial DNA (mtDNA) depletion by disrupting calcium transfer between the endoplasmic reticulum (ER) and mitochondria. This pathological calcium signaling causes ea...Mitochondrial DNA (mtDNA) mutations and depletion are key contributors to mitochondrial epilepsy and neurodegeneration, yet mechanistic studies and therapy development are hindered by the lack of suitable models. While caloric restrictio... -
Apr 27, 2025Researchers found how human genetics and intratumoral microbiota influence colorectal cancerIntratumoral microbiota plays a crucial role in cancer progression. However, the relationship between host genetics and intratumoral microbiota, as well as their interaction in colorectal cancer (CRC) progression, remains unclear. With 7...A recent study conducted by the Guangzhou Institutes of Biomedicine and Health (GIBH) of the Chinese Academy of Sciences (CAS), in collaboration with Sun Yat-sen University and the University of Hong Kong, investigated the association be... -
Apr 14, 2025Researchers discover a new mode of "mito-meet-to-mitochondria" (mtMET) in the regulation of stem cell fate by mitochondrial stressOn April 9, 2025, a research team led by LIU Xingguo from the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, published a paper titled "The mitochondrial unfolded protein response inhibits pluripotency acquis...Mitochondria play a crucial role in the acquisition of pluripotency and the determination of cell fate. The mitochondrial unfolded protein response (UPRmt) is an important retrograde regulatory pathway from mitochondria to the nucleus. I... -
Apr 03, 2025Researchers Unveil a Detailed Molecular Map of Mouse Lung DevelopmentA recent study conducted by the Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences (GIBH, CAS), in collaboration with the University of Science and Technology of China, Guangzhou Medical University,Guangzhou Natio... -
Feb 18, 2025The research team of GIBH discovered the target gene Lhx2 in hepatic stellate cells regulating liver regeneration and fibrosisRecently, the research teams of WANG Jie and LI Yinxiong from the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (GIBH, CAS), in collaboration with YUAN Shengxian's team from the Eastern Hepatobiliary Surgery...