People
CHEN Qi
Title:Group Leader
Subject:
Email:chen_qi@gibh.ac.cn
Address:190 Kaiyuan Avenue, Guangzhou Science Park, Huangpu District, Guangzhou
Study/Work Experience

2013.03-2021.07

Post-doctor, Department of Tissue Morphogenesis in Max Planck Institute for Molecular Biomedicine and Universitaetsklinikum Muenster, Muenster, Germany

2007.09-2013.02

Ph.D, Institute of Neuroscience (ION), Shanghai Institute for Biological Sciences, Chinese Academy of Science, Shanghai, China

2003.09-2007.07

B.S. Biology, East China University of Science and Technology(ECUST), Shanghai, China

Research Areas

(1) Vascular microenvironment for stem cell and tissue regeneration

(2) Interaction of hematopoietic stem cell and bone marrow microenvironment

Academic Performance

2019 Prize for poster in 7th German stem cell network annual meeting

2016 Chair Travel Award for the 2016 Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease

2012 Prize for poster in 7th International Kloster Seeon“angiogenesis” meeting (Rank First)

2011 Prize for poster in 7th European Zebrafish Meeting (Rank “Runner up”)

2010 Prize for oral presentation in annual retreat of ION (Rank Second)

2009 Prize of Olympus confocal imaging competition (Rank First)

2006 “ECUST-BASF (BadischeAnilin- und Soda-Fabrik)” joint scholarship Oral presentation in international meeting

2018 Oral presentation in Gordon Research Conference on Endothelial Cell Phenotypes in Health and Disease

2018 Oral presentation in EMBL Conference: Hematopoietic Stem cells: From the Embryo to the Aging Organism

2015 Oral presentation in 8th International Congress on Industrial and applied mathematics (Symposium: blood flow and blood vessel systems)

2015 Oral presentation in 6th cardiac regeneration and vascular biology

2015 Oral presentation in 13th Dutch German joint meeting of the molecular cardiology

2012 Oral presentation in 7th International Kloster Seeon “angiogenesis” meeting.

Representative Papers

Representative Papers:

(1) Lihui Lin, Jing Zhong, Fuqing Jiang, Yu-Xiang Wang, Lan-Yue Ma, Jia-Xin Yang, Yu-Yan Li , Rong-Rong Gao, Huijian Feng, Baomei Cai, Ziyu Feng, Xin Zhou, Ya-Hai Shu, Pan Chen, Xue W , Chen-Leng Cai, Qiang Wang, Guangming Wu, Duanqing Pei, Shangtao Cao, Yang Liu, Guangdun Peng, Jiekai Chen, Qi Chen. A single-cell time-series atlas of endothelial cell embryonic development. Cell. 2026 Feb 16:S0092-8674(26)00049-8. doi: 10.1016/j.cell.2026.01.002.

(2) Qi Chen#, Yang Liu#, Hyun-Woo Jeong, Martin Stehling, Van Vuong Dinh, Bin Zhou, Ralf H. Adams*. Apelin+ endothelial niche cells control hematopoiesis and mediate vascular regeneration after myeloablative injury. Cell Stem Cell, 2019 Dec 5;25(6):768-783.e6. doi: 10.1016/j.stem.2019.10.006. #Equal contribution

Cell Stem Cell Commentary: Mutualism in the Marrow 2019 Dec 5;25(6):731-733. doi: 10.1016/j.stem.2019.11.007.  


Other Papers:

(1)  Lan-Yue Ma, Zhao-Hua Deng, Ke Bai, Yan-Mei Yu, Yin Huang, Rong-Rong Gao, Yu-Yan Li, Xiao-Ling Li, Jia-Xin Yang, Ya-Hai Shu, Jinjin Ma, Yang Liu, Qi Chen. A single-cell hematopoietic microenvironmental atlas reveals progressive maturation of bone marrow vascular niche. Cell Regen. 2025 Dec 4;14(1):50. doi: 10.1186/s13619-025-00265-7.

(2) Yu-Xiang Wang, Zhao-Hua Deng, Yu-Yan Li, Ke Bai, Jinjin Ma*, Yang Liu*, Qi Chen*. Function of hematopoiesis and bone marrow niche in inflammation and non-hematopoietic diseases. Life Medicine.  2025 Mar 26;4(3):lnaf015.

(3) Jing Zhong, Rong-Rong Gao, Xin Zhang, Jia-Xin Yang, Yang Liu*, Jinjin Ma*, Qi Chen*. Dissecting endothelial cell heterogeneity with new tools. Cell Regeneration. 2025 Mar 23;14(1):10.

(4) Jian-Wei Chen, Yu-Xiang Wang, Rong-Rong Gao, Lan-Yue Ma, Jing Zhong, Jia-Xin Yang, Zhao-Hua Deng, Yu-Yan Li, Xiao-Ling Li, Ya-Hai Shu, Wen-Jing Guo, Zi-Yuan Zhou, Xiao Yu Tian, Jinjin Ma, Yang Liu*, Qi Chen*. CDK14 regulates the development and repair of lung. Cell Death Discov. 2025 Jan 18;11(1):12.

(5) Rong-Rong Gao, Lan-Yue Ma, Jian-Wei Chen, Yu-Xiang Wang, Yu-Yan Li, Zi-Yuan Zhou, Zhao-Hua Deng, Jing Zhong, Ya-Hai Shu, Yang Liu*, Qi Chen*. ATN-161 alleviates caerulein-induced pancreatitis. J Genet Genomics. 2024 Dec;51(12):1447-1458.

(6) Zhao-Hua Deng, Lan-Yue Ma, Qi Chen*, Yang Liu*. Dynamic crosstalk between hematopoietic stem cells and their niche from emergence to aging. Bioessays. 2023 Jan 27;e2200121. doi: 10.1002/bies.202200121

(7) Zhao-Hua Deng, Jing Zhong, Hai-Lin Jiang, Hyun-Woo Jeong, Jian-Wei Chen, Ya-Hai Shu, Ming Tan, Ralf H Adams, Ke-Ping Xie, Qi Chen*, Yang Liu*. Antipsychotic drugs induce vascular defects in hematopoietic organs. FASEB J. 2022 Oct;36(10):e22538. doi: 10.1096/fj.202200862R

(8) Yang Liu#, Qi Chen#, Hyun-Woo Jeong, Dong Han, Jörg Fabian, Hannes Drexler, Martin Stehling, Hans R. Schöler, Ralf H. Adams*. Dopamine signaling regulates hematopoietic stem and progenitor cell function. Blood, 2021 Nov 25;138(21):2051-2065. doi: 10.1182/blood.2020010419.

Blood Commentary: Dopamine motivates stem cells for reward. Blood. 2021 Nov 25;138(21):2012-2014. doi: 10.1182/blood.2021013538. 8 SCI citations

(9) Yang Liu#, Qi Chen#, Hyun-Woo Jeong#, Bong-Ihn Koh, Emma Watson, Cong Xu, Martin Stehling, Bin Zhou, Ralf H. Adams*. A specialized bone marrow microenvironment for fetal haematopoiesis. Nature Communications, 2022, 13 (1327). https://doi.org/10.1038/s41467-022-28775-x  

(10) Qi Chen, Hui Zhang, Yang Liu, Dagmar Zeuschner, Monica Corada, Elisabetta Dejana, Bin Zhou and Ralf H. Adams*. Endothelial cells are progenitors of cardiac pericytes and vascular smooth muscle cells. (2016) Nature Communications. 7:12422 doi: 10.1038/ncomms12422. 

(11) Qi Chen#, Luan Jiang#, Chun Li, Dan Hu, Ji-wen Bu, David Cai, Jiu-lin Du*.Haemodynamics- Driven Developmental Pruning of Brain Vasculature in Zebrafish. (2012) PLoS Biology 10(8): e1001374. #Equal contribution

Highlighted by Nature:Highlight in Neurodevelopment: Low flow blood vessel pruning. Nature (2012) 488(7413): 560. 

PLoS Biology Commentary: (2012) Pruning Brain Vasculature for Efficiency. PLoS Biol 10(8): e1001375