Dr. Li Wan received his PhD in Cell Biology from Zhejiang University, where he investigated the molecular mechanisms of DNA damage repair in Prof. Jun Huang's laboratory. He subsequently conducted postdoctoral research at the Francis Crick Institute in the laboratory of Prof. Jesper Q. Svejstrup (FRS, FMedSci). During this period, he undertook visiting research in Prof. Manu Hegde's laboratory at the MRC Laboratory of Molecular Biology in Cambridge, focusing on the molecular links between innate immune responses and protein synthesis.

Since October 2022, Dr. Wan has led an independent research group at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences. His group investigates molecular mechanisms of cellular stress and repair, with particular emphasis on innate immunity, protein synthesis, and DNA damage responses. The laboratory integrates cell biology, molecular biology, biochemistry, and structural biology with in vitro translation, quantitative proteomics, CRISPR-mediated genome editing, and ribosome analysis.

Oct 2022–Present Principal Investigator and Research Professor
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences

Jul 2016–Mar 2022 Postdoctoral Fellow
The Francis Crick Institute · Laboratory of Prof. Jesper Q. Svejstrup

Visiting Research Visiting Researcher
MRC Laboratory of Molecular Biology, Cambridge · Laboratory of Prof. Manu Hegde

Sep 2010–Jun 2015 PhD in Cell Biology
Zhejiang University

Sep 2006–Jun 2010 BSc in Biological Sciences
Northwest A&F University

1. Molecular mechanisms of innate immunity and immune-related diseases

2. Molecular mechanisms of genome stability and cancer development

3. Molecular mechanisms of cellular stress responses and disease

Li Wan is shown in bold; # corresponding author; * co-first author.

1. Jin-Gen Xu, Shi Chen, Yang He, Xi Zhu, Yanting Wang, Zhifeng Ye, Jin-Chuan Zhou, Xuanhui Wu, Lei Zhang, Xiaochen Ren, Huifeng Jia, Haijia Yu, Xiaoyue Wei, Yujie Feng, … Xiangyang Zhu#, Yifan Zhan#, Li Wan#. (2024). An Antibody Cocktail Targeting Two Different CD73 Epitopes Enhances Enzyme Inhibition and Tumor Control. Nature Communications, 15, 10872.

2. Li Wan, Szymon Juszkiewicz, Daniel Blears, Prashanth Kumar Bajpe, Zhong Han, Peter Faull, Richard Mitter, Ambrosius Snijders, Aengus Stewart, Ramanujan S. Hegde, and Jesper Q. Svejstrup. (2021). Translation stress and collided ribosomes are co-activators of cGAS. Molecular Cell, 81(13), 2808–2822.

3. Jinhua Han*, Li Wan*, Guixing Jiang, Liping Cao, Tian Tian, Feiyu Xia, Yi Luo, Yi Wang, Michael S. Y. Huen, Ting Liu, and Jun Huang. (2021). ATM controls the extent of DNA end resection by eliciting sequential posttranslational modifications of CtIP. Proceedings of the National Academy of Sciences of the USA, 118(12), e2022600118.

4. Li Wan and Jun Huang. (2014). The PSO4 complex associates with RPA and modulates the activation of ATR. Journal of Biological Chemistry, 289, 6619–6626.

5. Li Wan*, Jiangman Lou*, Yisui Xia*, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou, and Jun Huang. (2013). hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity. EMBO Reports, 14, 1104–1112.

6. Li Wan*, Jinhua Han*, Ting Liu*, Shunli Dong, Feng Xie, Hongxia Chen, and Jun Huang. (2013). Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. Proceedings of the National Academy of Sciences of the USA, 110, 10646–10651.

7. Ting Liu*, Li Wan*, Yue Wu, Junjie Chen, and Jun Huang. (2011). hSWS1-SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. Journal of Biological Chemistry, 286, 41758–41766.

1. Zhong Han, George A. Moore, Richard Mitter, David Lopez Martinez, Li Wan, A. Barbara Dirac Svejstrup, David S. Rueda, and Jesper Q. Svejstrup. (2023). DNA-directed termination of RNA polymerase II transcription. Molecular Cell, 83(18), 3253–3267.

2. Szymon Juszkiewicz, Shaun Speldewinde, Li Wan, Jesper Q. Svejstrup, and Ramanujan S. Hegde. (2020). The ASC-1 complex disassembles collided ribosomes. Molecular Cell, 79, 603–614.

3. Daniil Bespalov, Dayana Pino, Sònia Vidal-Guirao, Júlia Franquesa, Daniel Lopez-Ramajo, Ingrid Filgaira, Li Wan, Paul A. O'Sullivan, Steven C. Ley, Sonia Vanina Forcales, Juan José Rojas, Mercè Izquierdo-Serra, Concepció Soler, and Joan Manils. (2024). Bioinformatic analysis of molecular characteristics and oncogenic features of CARD14 in human cancer. Scientific Reports, 14(1), 22972.