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2010 – now |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/PI and Professor |
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2007 – 2010 |
Thomas Jefferson University/Research fellow |
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2002 – 2006 |
Tsinghua University/Ph.D. (Biology) |
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1998 – 2002 |
Shandong University/Bachelor (Biotechnology) |
(1) Organelle remodeling and metabolic controlling in cell fate determination
(2) Mechanisms of mitochondrial diseases and therapy
Professor Xingguo Liu, was honored as “Distinguish Youth Foundation” of National Natural Science Foundation, Chief Scientist of the National Key Research and Development Program of China (Twice), Recipients of special government allowances,1st finisher of the first prize of the Guangdong Science and Technology Award in Natural Science, The Shulan Medicine Youth Award by the Academician Shusen Lanjuan Talent’ Foundation, The Ying Ding Science and Technology Award, 2025 Chinese Society of Cell Biology-Promega Innovation Fund, “2016 Stem cell Young Investigator Award” from Chinese Society for Cell Biology and “Young Bioenergeticist Award” of the International Biophysical Society. He is President of the Chinese Society of Mitochondrial Biology, as well as the Vice President of the Asian Society for Mitochondrial Research and Medicine, the council member of the Biophysical Society of China, and a member of the expert group for the compilation of the special guideline of the National Key R&D Program "Developmental Programming and Its Metabolic Regulation" and “Synthetic Biology”. His papers have been cited for more than 10,000 times. He has published research papers as corresponding author,among which as sole/last corresponding author such as Cell, Cell Metabolism (2016, 2018, 2024), Nature Metabolism (2020, 2025), Nature Structural & Molecular Biology. Many papers are ESI High Cited, recommended by F1000, chosen as cover, and his findings have been listed in books such as Encyclopedia of Biological Chemistry. The result of "The first discovery of the 14th protein encoded by the mitochondrial gene" was selected as 1 of 11 representative achievements in biomedicine in the 2025 annual work report of the Chinese Academy of Sciences. The Cell paper was featured by Nature and Science News, and also published in a Xinhua News Agency press release. Dr. Liu has been the invited speaker in many international conferences such as Keystone Symposia.
Editor of Science Bulletin, J Biol Chem, Free Radical Biology and Medicine, FASEB Journal, Life Metabolism, MedComm
Vice President & Council member of the Asian Society for Mitochondrial Research and Medicine
President, the Mitochondrial Biology Branch, the Biophysical Society of China (Chinese Society of Mitochondrial Biology)
Council member of the Biophysical Society of China
Vice Chairman, the Stem Cell Engineering Technology Branch, the Biomedical Engineering Society of China
2020 “Distinguish Youth Foundation” of National Natural Science Foundation
2024 Chief Scientist of the National Key Research and Development Program of China
2018 Chief Scientist of the National Key Research and Development Program of China
2024 Selected as the annual work report of the Chinese Academy of Sciences (1 of 11 items in biomedicine)
2024 Recipients of special government allowances
2020 1st finisher of the first prize of the Guangdong Science and Technology Award in Natural Science
2021 Shulan Medicine Youth Award by the Academician Shusen Lanjuan Talent’ Foundation
2023 Ying Ding Science and Technology Award
2025 Chinese Society of Cell Biology-Promega Innovation Fund
2011 “2011 Young Bioenergeticist Award” from International Biophysical Society
2023 1st finisher of the first prize of the Guangdong Precision Medicine Award in Natural Sciences
2016 “Stem cell Young Investigator Award” from Chinese Society for Cell Biology
2012 Natural Science Funds for “Distinguished Young Scientists” of Guangdong
1. Du, S., Long Q.*, Zhou, Y.,...Liu, X*.(2026). Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson's disease models. Cell, 189(10):2821-2833. (Science, Nature News, Nature Genetics Highlights, Xinhua News Agency press release)
2. Hu, Z., Yang, L., Zhang, M.,…Liu, X*. (2024). A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development Cell Metabolism, 36(7):1586-1597.e7. (Cell Metabolism Preview)
3. Ying, Z., Xiang G., Zheng, L., …Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 28(6):935-945.
4. Ying, Z., Chen K., Zheng, L., …Liu, X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism, 23(1):220-226.
5. Li, L., Chen, K., Wang, T., …Liu, X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism 2(9):882-892. (ESI High Cited Biology&Biochemistry Top1%)
6. Ying, Z.*, Xin, Y., Liu, Z.,……Liu, X*. (2025). The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming. Nature Metabolism 7(5):940-951. (Nature Metabolism News，Nature Collection“A year of stem cell and developmental biology”)
7. Long, Q., Zhou, Y., Wu, H., …Liu, X*. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nature Structural & Molecular Biology 28(11):900-908.
8. Li, W., Long, Q., Wu, H., …Liu, X*. (2022). Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nature Communications, 13(1):7414. (Editors’ Highlights)
9. Yang, L., Ruan, Z., Lin, X., …Liu, X*. (2024). NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations. Nature Communications, 15: 546.
10. Hao, Z., Wu, Y., Huang, Y., …Liu, X*. (2025). Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development. Nature Communications, 16(1):10324.
11. Bao, F., Zhou, L., Zhou, R., …Tian, M*&Liu, X*. (2022). Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances, 8(15):eabk2376.
12. Wu, Y., Chen, K., Xing, G., …Liu, X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances, 5(11):eaax7525.
13. Guo, J., Duan, L., He, X., …Liu, X*. (2021). A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome. Advanced Science 8(10):2004680. (Cover)
14. Li, S., Guo, J., Ying, Z., ... Liu, X*. (2015). Valproic acid‐induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5):1730-1739.
15. Zhou, L., Bao, F., Zheng, J…Chen, G*&Liu, X*. (2025). Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer. Molecular Psychiatry 30(10):4749-4763.
16. Chen, K., Long, Q., Xing, G., …Pei, D*& Liu, X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal, 39(1):e99165 (F1000)
17. Liao, R., Wu, Y., Le, Q., … Liu, X* & Li, P*. (2023). BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO Journal, 42(21):e113448.
18. Xiang, G., Yang, L., Long, Q., …Liu, X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy, 13(9):1543-1555.
19. Zhou, Y., Long, Q., Wu, H., …Liu, X*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy, 16(3):562-574. (Cover)
20. Wu, Y.*, Liu, Y., Huang, Y., …Liu, X*. (2025). Post-transcriptional control of endogenous retroviruses by L1td1 suppresses totipotency acquisition in pluripotent stem cells, Cell Discovery, 2026 Jan 20;12(1):7. doi: 10.1038/s41421-025-00864-3.
21. Wu, Y., Chen, K., Li L., …Liu, X*. (2022). Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death & Differentiation, 29(11):2316-2331. (CDDpress: Readers’ Choice)
22. Xing, G., Liu, Z., Huang L., …Pei, D* Liu, X* & Chen, K*. (2022). MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. Cell Death & Differentiation, 29(5):1042-1054.
23. Lin, Y., Li, B.,…Liu, X*, Yan, C*, Ji, K*. (2025). Lactate-driven histone lactylation enhances GDF15 secretion in skeletal muscle under mtDNA mutation-induced mitochondrial stress. Science Bulletin 71(5):998-1002.
24.Xing, G., Huang Y.,Liu, W…Dong, M*, Liang, W*, Liu, X*, Chen K*. (2026) MAP2K6 directly phosphorylates Bcl2l13 to mediate mitophagy for suppressing tumorigenicity. Cell Reports, 45(4):117177.