2023 – now Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (CAS), Professor
2022 – 2023 National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, USA, Research Fellow
2017 – 2022 National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, USA, Postdoctoral Fellow
2014 – 2017 Department of Cancer Biology, Mayo Clinic, USA, Research Fellow
2009 – 2014 Beijing Institute of Genomics, Chinese Academy of Sciences, China, Ph.D.in Bioinformatics
2005 – 2009 Huazhong University of Science and Technology, China, B.S. in Biotechnology
Our main goal is to elucidate the detailed mechanisms of transcriptional regulation in cell fate decisions.
Major research directions:
· 1. Develop computational algorithms and deep learning models to analyze and interpret multi-omics data and regulatory sequences.
· 2. Characterize sequence determinants of regulatory elements, compatibility rules between promoters and enhancers, and cooperativity between transcription factors.
· 3. Decode gene regulatory network and their implications in cell fate decisions, such as cell differentiation, aging, and tumorigenesis.
1. Yongbing Zhao#*. TFSyntax: a database of transcription factors binding syntax in mammalian genomes. Nucleic Acids Research, 2023
2. Yongbing Zhao#*, Supriya V. Vartak#, Andrea Conte#, Xiang Wang#, David A. Garcia#, Evan Stevens, Seol Kyoung Jung, Kyong-Rim Kieffer-Kwon, Laura Vian, Timothy Stodola, Francisco Moris, Laura Chopp, Silvia Preite, Pamela L. Schwartzberg, Joseph M. Kulinski, Ana Olivera, Christelle Harly, Avinash Bhandoola, Elisabeth F. Heuston, David M. Bodine, Raul Urrutia, Arpita Upadhyaya, Matthew T. Weirauch, Gordon Hager and Rafael Casellas*. "Stripe" transcription factors provide accessibility to co-binding partners in mammalian genomes. Molecular Cell, 2022
3. Yongbing Zhao*, Jinfeng Shao, Yan W Asmann*. Assessment and Optimization of the Interpretability of Machine Learning Models Applied to Transcriptomic Data. Genomics, Proteomics and Bioinformatics, 2022
4. Yongbing Zhao#, Jinyue Wang#, Fang Liang, Yanxia Liu, Qi Wang, Hao Zhang, Meiye Jiang, Zhewen Zhang, Wenming Zhao, Yiming Bao, Zhang Zhang, Jiayan Wu, Yan W Asmann, Rujiao Li, Jingfa Xiao. NucMap: a database of genome-wide nucleosome positioning map across species. Nucleic Acids Research, 2019
5. Gaihua Zhang#, Yongbing Zhao#, Yi Liu#, Lipin Kao, Xiao Wang, Benjamin Skerry, and Zhaoyu Li. FOXA1 Defines Cancer Cell Specificity. Science Advances, 2016