HomePrincipal Investigator
Principal Investigator
Principal Investigator
Name：Hui Zheng
Professional：Principle Investigator
Email：zheng_hui@gibh.ac.cn
Address：No.190 Kaiyuan Road, Guangzhou Science Park, Luogang District, Guangzhou 510530
Study/Work Experience

2010.09–now

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Principal Investigator

2010.01–2010.09

Department of Pharmacology,  University of Minnesota/Postdoctoral Research Assistant

2005.08–2010.01

Department of Pharmacology,  University of Minnesota/Ph.D.

2001.09–2005.07

Tsinghua University/Bachelor

Research Areas

Dr. Zheng and his group focused on the mechanisms underlying different cell fate conversion processes, including somatic cell reprogramming, differentiation and trans-differentiation. The studies are related to cell biology, neuroscience, epigenetics, and pharmacology.

Academic Performance

Dr. Zheng and his group were supported by several programs from National Natural Science Foundation of China (NSFC) and Chinese Academy of Sciences (CAS), including the Science Fund for Creative Research Groups, the National Science Fund for Excellent Young Scholars, the Key program project, the Major program project and the General program project.

Dr. Zheng has published 35 manuscripts. He published 24 manuscripts as corresponding or co-corresponding author on Nat Cell Biology, PNAS, Biol Psychiatry，Neuropsychopharmacol，J Neurosci and so on. He published 23 manuscripts as co-authors. The Total impact factors of these manuscripts is over 200, and the citations of these manuscripts are over 800.

Dr. Zheng was the editor of IUBMB Life, Cell Regeneration, Frontiers in Cellular Endocrinology. He also severed or serves as the abstract reviewer of the annual meeting (2014) of International Society of Stem Cell Research, external reviewer of Research Grant Council GC (Hongkong), and the reviewer of grants from other department.

Representative Papers

1. He S, Sun H,……,Zheng H*.Passive DNA demethylation preferentially up-regulates pluripotency-related genes and facilitates the generation of induced pluripotent stem cells. The Journal of biological chemistry. 2017 Nov;292(45):18542-18555

2. Li W, He S,……,Zheng H*.Neurod1 Modulates Opioid Antinociceptive Tolerance via Two Distinct Mechanisms. Biological psychiatry. 2014 Nov;76(10):775-784

3. Zheng H*, Zhang Y, Li W, Loh HH, Law PY .NeuroD Modulates Opioid Agonist-Selective Regulation of Adult Neurogenesis and Contextual Memory Extinction. Neuropsychopharmacology. 2013 Apr;38(5):770-777

4. Liu X, Sun H, Qi J, Wang L,……Pei D*,Zheng H*.Sequential introduction of reprogramming factors reveals a time-sensitive requirement for individual factors and a sequential EMT-MET mechanism for optimal reprogramming. Nat Cell Biol. 2013 Jul;15(7):829-838

5. Zheng H*, Chu J, Qiu Y, Loh HH, Law PY. Agonist-selective signaling is determined by the receptor location within the membrane domains. Proceedings of the National Academy of Sciences of the United States of America.2008 Jul;105(27):9421-6.