Dr Zhang has published 7 publications as first or corresponding author in high impact scientific journals (Molecular Cell, Nature Protocols, EMBO.J et.al). During his master study, he found transcription factor Esrrb interacts with Nanog to maintain the expression of Oct-4, and explained the mechanisms of how Esrrb maintain the pluripotency of mouse ES cell in the absence of LIF. During his Ph.D study under the supervision of Prof. Peter ten Dijke in LUMC. Dr Zhang approved that the potential E2 conjugating enzyme UBE2O actually has both E2 conjugating and E3 ligase activity. In addition, he showed that UBE2O regulates the signal transduction of BMP and NF-kB signaling. After finished his Ph.D training, he moved to Prof. Michieil Vermeulen’s lab to learn proteomics using state-of-the-art mass spectrometry. He established an workflow called UbIA-MS to study the interactions of all ubiquitin linkages.
