Host modulation of HIV replication 

Targeting the key and fundamental scientific questions in HIV/AIDS field, Wang`s lab focuses on: 1) to reveal the novel mechanism of HIV transmission in acute infection; 2) to reveal mechanism of the establishment, maintenance and reactivation of HIV latency; 3) to develop therapeutic approaches for latency eradication. Regarding to the emerging viruses, Wang`s lab extends to uncover the invasion mechanisms, and viral pathogenesis, and develop strategies for prevention and control. The main achievements include:

1)      Uncovering the new mechanisms for HIV/retrovirus mucosal invasion, and develop new strategies for prevention;

2)      Identifying the key host factors that modulates HIV-1 transmission, replication and latency, which provides potential targets for therapy.

3)      He has published more than 50 scientific papers in journals, such as NUCLEIC ACID RES., MBIO, J VIROLOGY, etc.

1)       Qu D, Sun WW, Li L, Ma L, Sun L, Jin X, Li T*, Hou W*, Wang JH*. Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter. Nucleic Acids Res, 2019, PMID: 30788509.

2)       Zhou YH, Sun L, Chen J, Sun WW, Ma L, Han Y, Jin X, Zhao QX, Li T, Lu H, Qiu X*, Wang JH*. Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway to Promote HIV-1 Infection and Reactivation. mBio, 2019. PMID:31848275.

3)       Sun WW, Jiao S, Sun L, Zhou Z, Jin X, Wang JH*. SUN2 modulates HIV-1 infection and latency through association with lamin A/C to maintain the repressive chromatin. mBio, 2018. PMID: 29717016.

4)       Ma L, Jiang QA, Sun L, Yang X, Huang H, Jin X, Zhang C, Wang JH*. X-linked RNA-binding Motif Protein modulates HIV-1 infection of CD4⁺ T cells by maintaining the tri-methylation of histone H3 lysine 9 at the downstream region of the 5′ long terminal repeat of HIV proviral DNA. mBio, 2020, PMID: 32317327.

5)       Jiang AP, Jiang JF, Wei JF, Guo MG, Qin Y, Guo QQ, Ma L, Liu BC, Wang X, Veazey RS, Ding YB*, Wang JH*. Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells.  J Virol. 2015. PMID:26719250