HomePrincipal Investigator
Principal Investigator
Principal Investigator
Name：Jun He
Professional：Principle Investigator
Email：he_jun@gibh.ac.cn
Address：
Study/Work Experience
 

2018 – now

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/Principle Investigator

2016 – 2018

UCB Pharma/Senior Scientist

2013 – 2016

The Clare Hall Laboratories, the Francis Crick Institute/Post-doctoral Research Fellow

2012 – 2013

The Institute of Cancer Research/Post-doctoral Scientist

2008 – 2012

The Institute of Cancer Research/Ph.D

Research Areas
Studying mechanisms of macromolecular machines that play fundamental roles in cell fate determination by multi-disciplinary approaches including cryo-electron microscopy, x-ray crystallography and biochemistry.
Academic Performance
Most proteins form a network of interactions with other proteins and many are components of large complexes in vivo. Dr. He’s Group focus on those which play fundamental roles within the cell and aim to establish fundamental principles underlying the assembly of multi-protein complexes, define their structures, gain insight into their mechanisms using cryo-electron microscopy and x-ray crystallography. In the past, they have been successfully applied this hybrid approach to various macromolecular machines including proteasome, E3 ubiquitin ligase and DNA replication complex. They are now implementing these technologies to investigating fundamental mechanism of cell fate determination. They are also developing cutting-edge methodologies that can faithfully image the native cellular environment at high-resolution, aiming to reveal a complete structural description of the cell's native molecular landscape at certain stage.    
Representative Papers
 

1. Frigola, J.#, He, J.#, Kinkeilin, K., Pye, V., Renault, L., Douglas, M., Remus, D., Cherepanov, P. *, Costa, A.*, Diffley, J.F.X*. Cdt1 stabilises an open MCM ring for helicase loading. Nat. Commun. 2017 Jun;8:15720

2. He, J.#, Chao, W.C.#, Zhang, Z., Yang, J., Cronin, N.,Barford, D*. Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Molecular cell. 2013 Jun;50(5):649-660

3. da Fonseca, P. C.*, He, J.,Morris, E. P*. Molecular model of the human 26S proteasome. 2012 Mar;20(3):513-521

4. He, J.#, Kulkarni, K.#, da Fonseca, P. C., Krutauz, D., Glickman, M. H., Barford, D.*, Morris, E. P*. The Structure of the 26S Proteasome Subunit Rpn2 Reveals Its PC Repeat Domain as a Closed Toroid of Two Concentric α-Helical Rings. Structure. 2012 Mar;20(3):513-521