Faculty
XU Jinxin
Title：
Subject：
Email：xu_jinxin@gibh.ac.cn
Address：190 Kaiyuan Avenue, Guangzhou Science Park, Huangpu District, Guangzhou
Study/Work Experience
Research Areas
Academic Performance

AsCA Rising Star Award (2016)

Representative Papers

1. Wenjing Bai#, Jinxin Xu#, Wenbin Gu#, Danyang Wang#, Ying Cui#, Weidong Rong, Xiaoan Du, Xiaoxia Li, Cuicui Xia, Qingqing Gan, Guantao He, Huahui Guo, Jinfeng Deng, Ray-Whay Chiu Yen, Srinivasan Yegnasubramanian, Scott B. Rothbart, Cheng Luo, Linping Wu, Jinsong Liu, Stephen B. Baylin, Xiangqian Kong. Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy. Nature Communications (accepted).


2. Yulong Zhang#, Zhijun Yu#, Mingwei Sun, Ruyue Du, Hanhan Gao, Qiankun Dai, Yan Dong, Cuicui Liu, Menghui Yin, Tingting Xu, Xiaofei Zhang, Jinsong Liu*, Jinxin Xu*. Redox-modulated SNX25 as a novel regulator of GPCR-G protein signaling from endosomes. Redox Biology, 2024, 75: 10325.


3. Rui Chen, Feng Shen, Yulong Zhang, Mingze Sun, Yan Dong, Yue Yin, Chen Su, Chao Peng, Jinsong Liu*, Jinxin Xu*. Calcium modulates the tethering of BCOR-PRC1.1 enzymatic core to KDM2B via liquid-liquid phase separation. Communications Biology. 2024, 7(1):1112.


4. Lingyu Meng, Zhaojian Sun, Yulong Zhang, Yan Dong, Xiaoan Du, Yujian Wu, Yuan Yuan, Yirong Sun, Yong Xu, Huaiwei Ding*, Jinsong Liu*, Jinxin Xu*. Structural Studies on Mycobacterial NudC Reveal a Class of Zinc Independent NADH Pyrophosphatase. Journal of Molecular Biology, 2024, 436(23):168864.


5. Yulong Zhang, Rui Chen, Yan Dong, Jiabin Zhu, Kai Su, Jinsong Liu*, Jinxin Xu*. Structural studies reveal unique non-canonical regulators of G protein signaling homology (RH) domains in sorting nexins. Journal of Molecular Biology, 2022, 434(21): 167823.


6. Jinxin Xu#, Xin Jiang#, Yulong Zhang, Yan Dong, Changli Ma, Hanqiu Jiang, Taisen Zuo, Rui Chen, Yubin Ke, He Cheng, Howard Wang, Jinsong Liu. Multiscale characterization reveals oligomerization dependent phase separation of primer-independent RNA polymerase nsp8 from SARS-CoV-2. Communications Biology, 2022, 5: 925.


7. Rui Chen, Kai Su, Yulong Zhang, Yiguang Zhu, Jinsong Liu*, Jinxin Xu*. Co-crystal structure provides insights on transaminase CrmG recognition amino donor L-Arg. Biochemical and Biophysical Research Communications, 2023, 675:41-45.


8. Jinxin Xu#*, Xiaowen Tang#, Yiguang Zhu, Zhijun Yu, Kai Su, Yulong Zhang, Yan Dong, Weiming Zhu, Changsheng Zhang, Ruibo Wu, Jinsong Liu*. Structural studies reveal flexible roof of active site responsible for ω-transaminase CrmG overcoming by-product inhibition. Communications Biology, 2020, 3(1): 455.


9. Jinxin Xu#, Leilei Zhang#, Yinghua Ye, Yongli Shan, Chanjuan Wan, Junfeng Wang, Duanqing Pei, Xiaodong Shu*, Jinsong Liu*. SNX16 regulates the recycling of E-Cadherin through a unique mechanism of coordinated membrane and cargo binding. Structure, 2017, 25(8), 1251-1263.


10. Kai Su#, Tingting Xu#, Zhijun Yu, Jiabin Zhu, Yulong Zhang, Minhao Wu, Ying Xiong, Jinsong Liu, Jinxin Xu. Structure of the PX domain of SNX25 reveals a novel phospholipid recognition model by dimerization in the PX domain. FEBS letters, 2017, 591(13), 2011-20182.


11. You Wu, Tingting Xu, Jinsong Liu, Ke Ding*, Jinxin Xu*. Structural insights into the binding mechanism of IDO1 with hydroxylamidine based inhibitor INCB14943. Biochemical and Biophysical Research Communications, 2017, 487(2):339-343.


12. Yiguang Zhu#, Jinxin Xu#, Xiangui Mei#, Zhan Feng, Liping Zhang, Qingbo Zhang, Guangtao Zhang, Weiming Zhu*, Jinsong Liu*, Changsheng Zhang*. Biochemical and structural insights into the aminotransferase CrmG in caerulomycin biosynthesis. ACS Chemical Biology, 2016, 11: 943–952.


13. Shaohua Guo#, Jinxin Xu#, Ioannis V Pavlidis, Dongming Lan, Uwe T Bornscheuer, Jinsong Liu*, Yonghua Wang*. Structure of product‐bound SMG1 lipase: active site gating implications. FEBS Journal, 2015, 282(23): 4538-4547.


14. Jinxin Xu, Tingting Xu, Bin Wu, Yinghua Ye, Xiaojuan You, Xiaodong Shu, Duanqing Pei, Jinsong Liu. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. Journal of Biological Chemistry, 2013, 288(23): 16598-16605.