Faculty
ZHANG Lu
Title:
Subject:
Email:zhang_lu1@gibh.ac.cn
Address:190 Kaiyuan Avenue, Guangzhou Science Park, Huangpu District, Guangzhou
Study/Work Experience
Research Areas
Academic Performance
Representative Papers

1.Xiangqin He, Lu Zhang, Kunzhe Dong, David J Fulton, Chen-Leng Cai, Jiliang Zhou: The IncRNA, Cardiac Mesoderm Enhancer-Associated Noncoding RNA Is Indispensable for Intestinal Smooth Muscle Homeostasis in Female Mice as Revealed by a Novel Endogenous Myh11-Encoded Inducible Cre Model. Gastro Hep Adv 2024, 3(3):399-401.


2.Jaydev Dave, Nour Raad, Nishka Mittal, Lu Zhang, Anthony Fargnoli, Jae Gyun Oh, Maria Elisabetta Savoia, Jens Hansen, Marika Fava, Xiaoke Yin, Konstantinos Theofilatos, Delaine Ceholski, Erik Kohlbrenner, Dongtak Jeong, Lauren Wills, Mathieu Nonnenmacher, Kobra Haghighi, Kevin D Costa, Irene C Turnbull, Manuel Mayr, Chen-Leng Cai, Evangelia G Kranias, Fadi G Akar, Roger J Hajjar, Francesca Stillitano: Gene editing reverses arrhythmia susceptibility in humanized PLN-R14del mice: modelling a European cardiomyopathy with global impact. Cardiovasc Res 2022, 118(15):3140-3150.


3.Jian Ruan, Lu Zhang, Donghua Hu, Xianghu Qu, Fan Yang, Fuxue Chen, Xiangqin He, Jian Shen, Kunzhe Dong, Megan Sweet, Christina Sanchez, Deqiang Li, Weinian Shou, Jiliang Zhou, Chen-Leng Cai: Novel Myh11 Dual Reporter Mouse Model Provides Definitive Labeling and Identification of Smooth Muscle Cells-Brief Report. Arterioscler Thromb Vasc Biol 2021, 41(2):815-821.


4.Nour Raad, Philip Bittihn, Marine Cacheux, Dongtak Jeong, Zeki Ilkan, Delaine Ceholski, Erik Kohlbrenner, Lu Zhang, Chen-Leng Cai, Evangelia G Kranias, Roger J Hajjar, Francesca Stillitano, Fadi G Akar: Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Caused by Phospholamban R14del Mutation. Circulation 2021, 144(6):441-454.


5.Hiroko Nomaru, Yang Liu, Christopher De Bono, Dario Righelli, Andrea Cirino, Wei Wang, Hansoo Song, Silvia E Racedo, Anelisa G Dantas, Lu Zhang, Chen-Leng Cai, Claudia Angelini, Lionel Christiaen, Robert G Kelly, Antonio Baldini, Deyou Zheng, Bernice E Morrow: Single cell multi-omic analysis identifies a Tbx1-dependent multilineage primed population in murine cardiopharyngeal mesoderm. Nat Commun 2021, 12(1):6645.


6.Yuwen Chen, Deyong Xiao, Lu Zhang, Chen-Leng Cai, Bai-Yan Li, Ying Liu: The Role of Tbx20 in Cardiovascular Development and Function. Frontiers in cell and developmental biology 2021, 9:638542.


7.Donghua Hu, Lu Zhang, Fan Yang, Fuxue Chen, Deqiang Li, Chen-Leng Cai: Generation of Pecam1 endothelial specific dual reporter mouse model. Genesis 2020, 58(9):e23384.


8.Weibin Cai, Jing Tan, Jianyun Yan, Lu Zhang, Xiaoqiang Cai, Haiping Wang, Fang Liu, Maoqing Ye, Chen-Leng Cai: Limited Regeneration Potential with Minimal Epicardial Progenitor Conversions in the Neonatal Mouse Heart after Injury. Cell reports 2019, 28(1):190-201 e193.


9.Lu Zhang, Nishat Sultana, Jianyun Yan, Fan Yang, Fuxue Chen, Elena Chepurko, Feng-Chun Yang, Qinghua Du, Lior Zangi, Mingjiang Xu, Lei Bu, Chen-Leng Cai: Cardiac Sca-1(+) Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair. Circulation 2018, 138(25):2919-2930.


10.Jianyun Yan, Jun Li, Jun Hu, Lu Zhang, Chengguo Wei, Nishat Sultana, Xiaoqiang Cai, Weijia Zhang, Chen-Leng Cai: Smad4 deficiency impairs chondrocyte hypertrophy via the Runx2 transcription factor in mouse skeletal development. The Journal of biological chemistry 2018, 293(24):9162-9175.


11.Claire S Simon, Lu Zhang, Tao Wu, Weibin Cai, Nestor Saiz, Sonja Nowotschin, Chen-Leng Cai, Anna-Katerina Hadjantonakis: A Gata4 nuclear GFP transcriptional reporter to study endoderm and cardiac development in the mouse. Biology open 2018, 7(12).


12.Jingjing Li, Lianjie Miao, Chen Zhao, Wasay Mohiuddin Shaikh Qureshi, David Shieh, Hua Guo, Yangyang Lu, Saiyang Hu, Alice Huang, Lu Zhang, Chen-Leng Cai, Leo Q Wan, Hongbo Xin, Peter Vincent, Harold A Singer, Yi Zheng, Ondine Cleaver, Zhen-Chuan Fan, Mingfu Wu: CDC42 is required for epicardial and pro-epicardial development by mediating FGF receptor trafficking to the plasma membrane. Development 2017, 144(9):1635-1647.


13.Wenduo Ye, Yingnan Song, Zhen Huang, Marco Osterwalder, Anja Ljubojevic, Jue Xu, Brent Bobick, Samuel Abassah-Oppong, Ningsheng Ruan, Ross Shamby, Diankun Yu, Lu Zhang, Chen-Leng Cai, Axel Visel, Yanding Zhang, John Cobb, YiPing Chen: A unique stylopod patterning mechanism by Shox2-controlled osteogenesis. Development 2016, 143(14):2548-2560.


14.Jianyun Yan, Lu Zhang, Nishat Sultana, Jae Gyun Oh, Bingruo Wu, Roger J Hajjar, Bin Zhou, Chen-Leng Cai: A series of robust genetic indicators for definitive identification of cardiomyocytes. Journal of molecular and cellular cardiology 2016, 97:278-285.


15.Jianyun Yan, Lu Zhang, Nishat Sultana, David S Park, Akshay Shekhar, Lei Bu, Jun Hu, Shegufta Razzaque, Chen-Leng Cai: A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction. PLoS One 2015, 10(7):e0133472.


16.Jianyun Yan, Nishat Sultana, Lu Zhang, David S Park, Akshay Shekhar, Jun Hu, Lei Bu, Chen-Leng Cai: Generation of a tamoxifen inducible Tnnt2MerCreMer knock-in mouse model for cardiac studies. Genesis 2015, 53(6):377-386.


17.Nishat Sultana, Lu Zhang, Jianyun Yan, Jiqiu Chen, Weibin Cai, Shegufta Razzaque, Dongtak Jeong, Wei Sheng, Lei Bu, Mingjiang Xu, Guo-Ying Huang, Roger J Hajjar, Bin Zhou, Anne Moon, Chen-Leng Cai: Resident c-kit(+) cells in the heart are not cardiac stem cells. Nature communications 2015, 6:8701.


18.Lu Zhang, Aya Nomura-Kitabayashi, Nishat Sultana, Weibin Cai, Xiaoqiang Cai, Anne M Moon, Chen-Leng Cai: Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development. Developmental biology 2014, 390(1):68-79.


19.Jianyun Yan, Lu Zhang, Jinshu Xu, Nishat Sultana, Jun Hu, Xiaoqiang Cai, Jun Li, Pin-Xian Xu, Chen-Leng Cai: Smad4 regulates ureteral smooth muscle cell differentiation during mouse embryogenesis. PLoS One 2014, 9(8):e104503.


20. Xiaoqiang Cai, Weijia Zhang, Jun Hu, Lu Zhang, Nishat Sultana, Bingruo Wu, Weibin Cai, Bin Zhou, Chen-Leng Cai: Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development 2013, 140(15):3176-3187.