In recent years, Dr Chen’s research team has the following achievements: 1) showed heterochromatin loosening mediated by Oct4 in early stage of iPSC reprogramming, and identified heterochromatin looseners such as Gadd45a and Mkk6, which can relax heterochromatin in different patterns during reprogramming. 2) proposed a new concept of “epigenome-metabolome-epigenome” cascade mediated by Glis1 during pluripotency acquisition. 3) revealed the cooperation between lipid droplets and mitochondria regulates pluripotency by maintaining Molecular mechanism of lipid droplet mitochondrial interaction to maintain fatty acid oxidation and histone acetylation.
2021, Excellent member of Youth Innovation Promotion Association CAS
2020, First Prize of Natural Sciences of Guangdong Province
2017, Outstanding Science and Technology Achievement Prize of the Chinese Academy of Sciences
1. Guangsuo Xing, Zichao Liu, Luyuan Huang, Danyun Zhao, Tao Wang, Hao Yuan, Yi Wu, Linpeng Li, Qi Long, Yanshuang Zhou, Zhihong Hao, Yang Liu, Jianghuan Lu, Shiting Li, Jieying Zhu, Bo Wang, Junwei Wang, Jing Liu, Jiekai Chen, Duanqing Pei*, Xingguo Liu*, Keshi Chen*. MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, Cell Death & Differentiation, 2022, 29(5):1042-1054
2. Yi Wu#, Keshi Chen#, Linpeng Li#, Zhihong Hao#, Tianyu Wang, Yang Liu, Guangsuo Xing, Zichao Liu, Heying Li, Hao Yuan, Jianghuan Lu, Cheng Zhang, Jinye Zhang, Danyun Zhao, Junwei Wang, Jinfu Nie, Dan Ye, Guangjin Pan, Wai-Yee Chan, Xingguo Liu*. Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, Cell Death & Differentiation, 2022, 29(11):2316-2331
3. Linpeng Li#, Keshi Chen#, Tianyu Wang#, Yi Wu#, Guangsuo Xing, Mengqi Chen, Zhihong Hao, Cheng Zhang, Jinye Zhang, Bochao Ma, Zihuang Liu, Hao Yuan, Zijian Liu, Qi Long, Yanshuang Zhou, Juntao Qi, Danyun Zhao, Mi Gao, Duanqing Pei, Jinfu Nie, Dan Ye, Guangjin Pan, Xingguo Liu*. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism, 2020, 2(9): 882-892
4．Keshi Chen; Qi Long; Guangsuo Xing; Tianyu Wang; Yi Wu; Linpeng Li; Juntao Qi; Yanshuang Zhou; Bochao Ma; Hans R Scholer; Jinfu Nie; Duanqing Pei *; Xingguo Liu *, Heterochromatin loosening by Oct4 linker facilitates Klf4’s binding and initiates iPSC reprogramming. EMBO Journal, 2020, 39(1):e99165
5. Yi Wu #; Keshi Chen#; Guangsuo Xing; Linpeng Li; Bochao Ma; Zhijuan Hu; Lifan Duan; Xingguo Liu*, Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Science Advances, 2019, 5(11):eaax7525