Patents
• Application of NCoR/SMRT protein complex in the regulation of cell fate transition, 201610064508.7, Miguel A. Esteban;Qiang Zhuang;Christina Benda;Andrew Hutchins;Wenjuan Li;Yan Xu
• Media and Methods for Establishing and Maintaining Early Embryo-Like Cells, 202011256758.3, Miguel A. Esteban, Mazid M. Abdul, Wenjuan Li, Zhiwei Luo, Carl Ward, Yunpan Li, Yiwei Lai
• Media and Methods for Establishing and Maintaining Early Embryo-Like Cells, PCT/CN2020/128091, Miguel A. Esteban, Mazid M. Abdul, Wenjuan Li, Zhiwei Luo, Carl Ward, Yunpan Li, Yiwei Lai
• Media and Methods for Producing Human Cells and Tissues from Teratoma, Organoids and Embryoid Bodies, 202211317527.8, Miguel A. Esteban, Wenjuan Li, Mazid M. Abdul, Yu Jiang, Yiwei Lai, Zhiwei Luo, Jinxiu Li
• Media and Methods for Producing Human Cells and Tissues from Teratoma, Organoids and Embryoid Bodies, PCT/CN2022/081499, Miguel A. Esteban, Wenjuan Li, Mazid M. Abdul, Yu Jiang, Yiwei Lai, Zhiwei Luo, Jinxiu Li
Guangdong Special Support Plan-Science and Technology Innovation Young Top-notch Talents, 2024
• Md. Abdul Mazid*#, Carl Ward#, Zhiwei Luo#, Chuanyu Liu#, Yunpan Li, Yiwei Lai, Liang Wu, Jinxiu Li, Wenqi Jia, Yu Jiang, Hao Liu, Lixin Fu, Yueli Yang, David P. Ibañez, Junjian Lai, Xiaoyu Wei, Juan An, Pengcheng Guo, Yue Yuan, Qiuting Deng, Yang Wang, Ying Liu, Fei Gao, Junwen Wang, Shahriar Zaman, Baoming Qin, Guangming Wu, Patrick H. Maxwell, Xun Xu, Longqi Liu*, Wenjuan Li*, Miguel A. Esteban*. Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage. Nature, 2022 (605): 315-324
• Yueli Yang#, Wenqi Jia#, Zhiwei Luo, Hao Liu, Yunpan Li, David P. Ibañez, Jinxiu Li, Yu Jiang, Lixin Fu, Junjian Lai, Liang Wu, Yiwei Lai, Longqi Liu, Miguel A. Esteban*, Md Abdul Mazid*, Wenjuan Li*. VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification. Nature Communications, 2024 15, 583
• Jing Cao#, Wenjuan Li#, Jie Li#, Md. Abdul Mazid#, Chunyang Li#, Yu Jiang#, Wenqi Jia#, Zhaodi Liao, Shiyu Sun, Jiqiang Fu, Yan Wang, Yong Lu, Yuting Xu, Yanhong Nie, Xinyan Bian, Changshan Gao, Xiaotong Zhang, Liansheng Zhang, Yunpan Li, Lixin Fu, Hao Liu, Junjian Lai, Yang Wang, Yue Yuan, Yiwei Lai, Longqi Liu, Xiaolong Wang, Qiang Sun*, Miguel A. Esteban*, Zhen Liu*. Live Birth of Chimeric Macaque Monkey with High Contribution from Homologous Embryonic Stem Cells. Cell, 2023 186(23): 4996-5014
• Jiaowei Wang#, Wenguang Xie#, Nan Li#, Wenjuan Li#, Zhishuai Zhang#, Nana Fan, Zhen Ouyang, Yu Zhao, Chengdan Lai, Hao Li, Mengqi Chen, Longquan Quan, Yunpan Li, Yu Jiang, Wenqi Jia, Lixin Fu, Md. Abdul Mazid, Yanling Zhu, Patrick H. Maxwell, Guangjin Pan*, Miguel A. Esteban*, Zhen Dai*, Liangxue Lai*. Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation. Cell Stem Cell, 2023 30(9): 1235-1245
• Qiang Zhuang#, Wenjuan Li#, Christina Benda#, Zhijian Huang, Tanveer Ahmed, Ping Liu, Xiangpeng Guo, David P Ibañez, Zhiwei Luo, Meng Zhang, Mazid Md Abdul, Zhongzhou Yang, Jiayin Yang, Yinghua Huang, Hui Zhang, Dehao Huang, Jianguo Zhou, Xiaofen Zhong, Xihua Zhu, Xiuling Fu, Wenxia Fan, Yulin Liu, Yan Xu, Carl Ward, Muhammad Jadoon Khan, Shahzina Kanwal, Bushra Mirza, Micky D Tortorella, Hung-Fat Tse, Jiayu Chen, Baoming Qin, Xichen Bao, Shaorong Gao, Andrew P. Hutchins*, Miguel A. Esteban*. NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming. Nature Cell Biology, 2018 20(4): 400-412
• Yunpan Li, David P. Ibanez, Wenxia Fan, Ping Zhao, Shuhan Chen, Mazid Md. Abdul, Yu Jiang, Lixin Fu, Zhiwei Luo, Zhenhua Liu, Yueli Yang, Jifeng Guo, Giacomo Volpe, Shahzina Kanwal, Dongye Wang, Beisha Tang*, Wenjuan Li*. Generation of an induced pluripotent stem cell line (GIBHi004-A) from a Parkinson's disease patient with mutant DJ-1/PARK7 (p.L10P). Stem Cell Research, 2020 46: 101845.
• Zhiwei Luo, Xiaobing Qing, Christina Benda, Zhijian Huang, Meng Zhang, Yinghua Huang, Hui Zhang, Lulu Wang, Yiwei Lai, Carl Ward, Giacomo Volpe, Xiaofen Zhong, Baoming Qin, Qiang Zhuang**, Miguel A. Esteban*, Wenjuan Li*. Nuclear-cytoplasmic shuttling of class IIa histone deacetylases regulates somatic cell reprogramming. Cell Regeneration, 2019 8(1):21-29.
• Jiayi Wei#, Yueyang Sun#, Heming Wang#, Tong Zhu#, Li Li#, Ying Zhou, Quan Liu, Zhen Dai, Wenjuan Li, Taihua Yang, Bingmei Wang, Changfeng Zhu, Xizhong Shen, Qunyan Yao, Guangqi Song, Yicheng Zhao and Hao Pei. Designer cellular spheroids with DNA origami for drug screening. Science Advances, 2024 (10), eado9880
• Jinxiu Li#, Lixin Fu#, Yunpan Li#, Wei Sun, Yao Yi, Wenqi Jia, Haiwei Li, Hao Liu, Pengcheng Guo, Yang Wang, Yue Shen, Xiuqing Zhang, Yuan Lv, Baoming Qin, Wenjuan Li, Chuanyu Liu, Longqi Liu, Md. Abdul Mazid, Yiwei Lai, Miguel A. Esteban, Yu Jiang* and Liang Wu*. A single-cell chromatin accessibility dataset of human primed and naïve pluripotent stem cell-derived teratoma. Scientific Data, 2024, 11:725
• Jie Li#, Qingyuan Zhu#, Jing Cao#, Ying Liu#, Yong Lu#, Yining Sun, Qian Li, Yiming Huang, Shenshen Shang, Xinyan Bian, Chunyang Li, Liansheng Zhang, Yan Wang, Yanhong Nie, Jiqiang Fu, Wenjuan Li, Md. Abdul Mazid, Yu Jiang, Wenqi Jia, Xiaolong Wang, Yidi Sun, Miguel A. Esteban, Qiang Sun*, Fan Zhou* and Zhen Liu*. Cynomolgus monkey embryo model captures gastrulation and early pregnancy. Cell Stem Cell, 2023 (30), 362–377.
• Li Chen, Qiaoqiao Tong, Xiaowen Chen, Penglei Jiang, Hua Yu, Qianbing Zhao, Lingang Sun, Chao Liu, Bin Gu, Yuping Zheng, Lijiang Fei, Xiao Jiang, Wenjuan Li, Giacomo Volpe, Mazid MD. Abdul, Guoji Guo, Jin Zhang, Pengxu Qian, Qiming Sun, Dante Neculai, Miguel A. Esteban, Chen Li, Feiqiu Wen and Junfeng Ji. PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus. Nature Communications, 2021, 12(1).
• Isaac A. Babarinde, Gang Ma, Yuhao Li, Boping Deng, Zhiwei Luo, Hao Liu, Mazid Md. Abdul, Carl Ward, Minchun Chen, Xiuling Fu, Liyang Shi, Martha Duttlinger, Jiangping He, Li Sun, Wenjuan Li, Qiang Zhuang, Guoqing Tong, Jon Frampton, Jean-Baptiste Cazier, Jiekai Chen, Ralf Jauch, Miguel A. Esteban and Andrew P. Hutchins. Transposable element sequence fragments incorporated into coding and noncoding transcripts modulate the transcriptome of human pluripotent stem cells. Nucleic Acids Research, 2021, 49(16).
• Meng Zhang#, Yiwei Lai#, Vladislav Krupalnik#, Pengcheng Guo, Xiangpeng Guo, Jianguo Zhou, Yan Xu, Zhijun Yu, Longqi Liu, Ao Jiang, Wenjuan Li, Mazid Md. Abdul, Gang Ma, Na Li, Xiuling Fu, Yuan Lv, Mengling Jiang, Muqddas Tariq, Shahzina Kanwal, Hao Liu, Xueting Xu, Hui Zhang, Yinghua Huang, Lulu Wang, Shuhan Chen, Isaac A. Babarinde, Zhiwei Luo, Dongye Wang, Tiantian Zhou, Carl Ward, Minghui He, David P. Ibañez, Yunpan Li, Jiajian Zhou, Jie Yuan, Yayan Feng, Karthik Arumugam, Umberto Di Vicino, Xichen Bao, Guangming Wu, Axel Schambach, Huating Wang, Hao Sun, Fei Gao, Baoming Qin, Andrew P. Hutchins, Bradley W. Doble, Christine Hartmann, Maria Pia Cosma, Yan Qin, Guo-Liang Xu, Runsheng Chen, Giacomo Volpe, Liang Chen*, Jacob H. Hanna* and Miguel A. Esteban*. β-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus. Science Advances, 2020, 6(29).
• Meng Zhang, David P. Ibañez, Wenxia Fan, Hao Liu, Xiaofen Zhong, Xiwei Wang, Yingying Li, Mazid Md. Abdul, Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Ping Zhao, Zhiwei Luo. Generation of a PARK2 homozygous knockout induced pluripotent stem cell line (GIBHi002-A-1) with two common. Stem Cell Research, 2019 (41).
• Jiangping He, Xiuling Fu, Meng Zhang, Fangfang He, Wenjuan Li, Mazid Md. Abdul, Jianguo Zhou, Li Sun, Chen Chang, Yuhao Li, He Liu, Kaixin Wu, Isaac A. Babarinde, Qiang Zhuang, Yuin-Han Loh, Jiekai Chen, Miguel A. Esteban and Andrew P. Hutchins. Transposable elements are regulated by context-specific patterns of chromatin marks in mouse embryonic stem cells. Nature Communications, 2019, 10(1), 34.
• Mazid Md. Abdul, David P. Ibañez, Ping Zhao, Hao Liu, Xiaofen Zhong, Yingying Li, Meng Zhang, Wenjuan Li, Yunpan Li, Carl Ward, Shuhan Chen, Dongye Wang, Baoming Qin, Miguel A. Esteban, Xiwei Wang*, Wenxia Fan*, Zhiwei Luo. Generation of an induced pluripotent stem cell line (GIBHi003-A) from a Parkinson's disease patient with mutant PINK1 (p. I368N). Stem Cell Research, 2019 (41).
• Lulu Wang, Xueting Xu, Che Jiang, Gang Ma, Yinghua Huang, Hui Zhang, Yiwei Lai, Ming Wang, Tanveer Ahmed, Runxia Lin, Wenjing Guo, Zhiwei Luo, Wenjuan Li, Meng Zhang, Carl Ward, Minxian Qian, Baohua Liu, Miguel A. Esteban and Baoming Qin (2019) mTORC1-PGC1 axis regulates mitochondrial remodeling during reprogramming. The FEBS Journal. 2020 287(1):108-121.
• Li Li, Quanjun Zhang, Huaqiang Yang, Qingjian Zou, Chengdan Lai, Fei Jiang, Ping Zhao, Zhiwei Luo, Jiayin Yang, Qian Chen, Yan Wang, Philip N. Newsome, Jon Frampton, Patrick H. Maxwell, Wenjuan Li, Shuhan Chen, Dongye Wang, Tak-Shing Siu, Sidney Tam, Hung-Fat Tse, Baoming Qin, Xichen Bao, Miguel A. Esteban* and Liangxue Lai*. Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1. The Journal of Biological Chemistry, 2017, (292) 11, 4755–4763.
• Yan Xu#, Meng Zhang#, Wenjuan Li, Xihua Zhu, Xichen Bao, Baoming Qin, Andrew P. Hutchins* and Miguel A. Esteban*. Transcriptional Control of Somatic Cell Reprogramming. Trends in Cell Biology. 2016 26(4):272-288.
• Longqi Liu#, Yan Xu#*, Minghui He#, Meng Zhang, Fenggong Cui, Leina Lu, Mingze Yao, Weihua Tian, Christina Benda, Qiang Zhuang, Zhijian Huang, Wenjuan Li, Xiangchun Li, Ping Zhao, Wenxia Fan, Zhiwei Luo, Yuan Li, Yasong Wu, Andrew P. Hutchins, Dongye Wang, Hung-Fat Tse, Axel Schambach, Jon Frampton, Baoming Qin, Xichen Bao, Hongjie Yao, Biliang Zhang, Hao Sun, Duanqing Pei, Huating Wang, Jun Wang, and Miguel A. Esteban*. Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming. Cell Stem Cell, 2014 15, 1-15.