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2019.09-2023.12 |
In-situ regeneration technology and transfer Research based on adaptive intelligent biomaterials for stem cell microenvironment，National Key R&D Program of China， Project leader |
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2020.01-2021.12 |
Multifunctional PHAs for siRNA delivery application，Science and Technology Project of Guangdong Province， Project principal |
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2019.01-2020.12 |
Tumor targeting small interfering nucleic acid drug delivery system，Guangzhou Development Zone， Leader of sub-project; 2017.7-2020.12： Preclinical study of anti-osteoarthritis siRNA drug，National Science and Technology Major Projects for New Drug Development， Leader of sub-project |
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2016.03-2018.02 |
Rational design and development of mRNA transfection reagent, Science and Technology Project of Guangzhou City, Project principal |
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2015.10-2017.09 |
Development of mRNA transfection reagent for in vitro and in vivo study, International Science and Technology Cooperation of Guangdong Province, Project principal |
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2013.01-2017.12 |
Development and phase-I clinical trials of novel therapeutic nanotechnology-enabled systems for the diagnosis and treatment of atherosclerosis, European 7th Framework Programme, Second Principal of sub-project |
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2010.01-2013.12 |
Nanoparticles for Therapy and Diagnosis of Alzheimer Disease, European 7th Framework Programme, Second Principal of sub-project |
Oligonucleotide drug discovery; Design, bio-/chemical synthesis and nano-engineering of biomaterials for translational nanomedicine application, such as drug specific targeting delivery and tissue nano-scaffolds with stem cell for personal diagnosis and therapy; Nano-toxicity study (innate immune system in relation to nanoparticle performance and safety).
Patents
1.Peptidic nanodelivery composition targeting two receptors. PCT：PCT/EP2014/067651.
2.Nano-systems for therapy and/or diagnosis and/or therapy monitoring and/or theranostics of disease. PCT：PCT/EP2017/060579.
•Excellent expert of Guangzhou City (2022)
• "Pearl River Talent Program" high-level talent (2017)
•Chinese government award for outstanding self-financed students abroad (2013)
•PhD scholarship, Copenhagen University and Lundbeck foundation (2010)
1. Yuan W#, Huang C#, Deng W, Lai J, Chen J , Jie J, Wu Y, You T* and Wu LP*. (2024) Hyaluronic acid Methacryloyl/Chitosan Methacryloyl/3-Methacrylamidophenylboronic acid multifunctional hydrogel loading Exosome for diabetic wound healing. International Journal of Biological Macromolecules, 280, 135562.
2. Hou J#, Jie J#, Wei X#, Shen X, Zhao Q, Chai X, Pang H, Shen Z, Wang J, Wu LP*and Xu J*.(2024) A core-shell-type nanosystem promotes diabetic wound healing through Photothermal-responsive release of transforming growth factor β. Journal of Nanobiotechnology , 22:449.
3. Lin L, Zhu S, Huang H, Wu LP*, Huang J*.(2023) Chemically modified small interfering RNA targeting Hedgehog signalling pathway for rheumatoid arthritis therapy. Molecular Therapy - Nucleic Acids, 31, 88-104.
4. Li Y#, Yang T#, Cheng Y#, Hou J#, Liu Z, Zhao Y, Chen S, Qin Z, Wang C, Song W, Ge H, Li C, Liang L, Guo L, Sun H, Wu LP*, Zheng H*. (2023) Low glutaminase and glycolysis correlate with a high transdifferentiation efficiency in mouse cortex. Cell Proliferation, 56(5):e13422.
5. Guo Y, Wu LP*, Qiu F-G*.(2022) Highly diastereo- and enantioselective formal [4 + 2] cyclization of nitroalkenes and unsaturated ketoesters under phase-transfer catalysis. Organic letters, 45, 8370–8374 .
6. Wu LP, Ficker M, Christensen JB, Simberg，D Trohopoulos PN, Moghimi SM*.(2021). Dendrimer end-terminal motif-dependent evasion of human complement and complement activation through IgM hitchhiking. Nature Communications, 12, 4858.
7. Deng W, Zhang Y, Wang W, Song A, Mukama O, Huang J, Han X, Deng S, Lin Z, Habimana JD, Huang R, Peng K, Ni B, Zhang S, Yan X, Li J, Wu LP*, Li Z*.(2021) Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle. Stem Cell Research & Therapy,12, 548
8. Pannuzzo M#, Esposito S#, Wu LP#, Key J, Aryal S, Celia C, Marzio LD, Moghimi SM*, Decuzzi P*.(2020) Overcoming nanoparticle-mediated complement activation by surface PEG-pairing. Nano letters, 20: 4312-4321.
9. Wu LP*, Ahmadvand D, Su JA, Hall A, Tan XL, Farhangrazi AZ, Moghimi SM*.(2019). Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display peptide. Nature Communications, 10, 4635.
10. Wu LP*, Wang DY, Li ZB. (2020). Grand challenges in nanomedicine. Materials Science and Engineering C, 106, 110302.
11. Xu Z, Wang D, Cheng Y, Yang M, Wu LP*. (2018). Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C, 92, 1006–1015.
12. Wu LP, Ficker M, Mejlsøe SL, Hall A, Paolucci V, Christensen JB, Trohopoulos PN, Moghimi SM*. (2017). Poly-(amidoamine) dendrimers with a precisely core positioned sulforhodamine B molecule for comparative biological tracing and profiling. Journal of Controlled Release, 246, 88-97.
13. Wang D, Wu LP*. (2017). Nanomaterials for delivery of nucleic acid to the central nervous system (CNS). Materials Science and Engineering: C, 70, 1039–1046.
14. Wu LP, Uldahl KB, Chen FF, Benasutti H, Logvinski D, Vu V,. Banda NK, Peng X, Simberg D, Moghimi SM*. (2017) .Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice. Molecular Immunology, 90:273-279.
15. Wu LP*, Moghimi SM. (2016) A nanoengineered peptidic delivery system with specificity for human brain capillary endothelial cells. Nanomedicine: NBM, 12(2), 474-475.
16. Han J#, Wu LP#, Hou J, Zhao D, Xiang H*. (2015). Biosynthesis, Characterization and Hemostasis Potential of Tailor-Made Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Produced by Haloferax mediterranei. Biomacromolecules，16 (2), 578–588
17. Wu LP, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM*. (2015). Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges. Bioconjugate chemistry，26(7), 1198-1211.
18. Wu LP, Wang DY, Parhamifar L, Hall A, Chen G-Q, Moghimi, SM*. (2014). Poly (3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking. Advanced healthcare materials, 3(6), 817-824.
19. Wu LP#, You ML#, Wang DY, Peng GF, Wang ZH, CHEN G-Q*. (2013). Fabrication of Carbon Nanotubes (CNTs)/ Poly(3-hydroxyburyrate-co-3-hydroxyhexanoate) (PHBHHx) Nanocomposite Films for Human Mesenchymal Stem Cells (hMSCs) Differentiation. Polymer Chemistry, 4, 4490-4498.
20. Wu LP#, Tripathi L#, Chen JC, Chen G-Q*. (2012).Synthesis of diblock copolymer poly-3-hydroxybutyrate-block-poly-3-hydroxy -hexanoate [PHB-b-PHHx] by a beta-oxidation weakened Pseudomonas putida KT2442. Microbial Cell Factories, 11:44.
21. Wu LP, Wang XJ, Cheng ST, Xu KT*. (2010). Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone). Acta Biomaterialia, 6, 1079-1089.
22. Wu LP, Cheng ST, Li ZB, Chen G-Q*, Xu KT*. (2008). Synthesis, characterization and biocompatibility of novel biodegradable poly[((R)-3-hydroxybutyrate)-block-(D,L-lactide)- block-(ε-caprolactone)] triblock copolymers. Polymer International, 57, 939-949.
23. Kim HS, Chen JY, Wu LP, Wu JH, Xiang H*, Leong KW, Han J*. (2020) Prevention of excessive scar formation using nanofibrous meshes made of biodegradable elastomer poly(3-hydroxybutyrate- co-3-hydroxyvalerate). Journal of Tissue Engineering, 11, 1–12.
24. Xu Z, Wang D, Cheng Y, Yang M, Wu LP*. (2018). Polyester based nanovehicles for siRNA delivery. Materials Science and Engineering C, 92, 1006–1015.
25. Chen C#, Wang G#, Griffin J, Brenneman B, Banda N, Holers V, Backos D, Wu LP, Moghimi SM, Simberg D*. (2017). Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo. Nature Nanotechnology, 12(4), 387-393.
26. Wang D, Wu LP*. (2017). Nanomaterials for delivery of nucleic acid to the central nervous system (CNS). Materials Science and Engineering: C, 70, 1039–1046.
27. Uldahl KB#, Wu LP#, Hall A, Papathanasiou P, Peng X*, Moghimi SM*. (2017). Recognition of extremophilic archaeal viruses by eukaryotic cells: a promising nanoplatform from the third domain of life. Scientific Reports, 6, 37966.
28. Wu LP, Uldahl KB, Chen FF, Benasutti H, Logvinski D, Vu V,. Banda NK, Peng X, Simberg D, Moghimi SM*. (2017) .Interaction of extremophilic archaeal viruses with human and mouse complement system and viral biodistribution in mice. Molecular Immunology, 90:273-279.
29. Han J#, Wu LP#, Hou J, Zhao D, Xiang H*. (2015). Biosynthesis, Characterization and Hemostasis Potential of Tailor-Made Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) Produced by Haloferax mediterranei. Biomacromolecules，16 (2), 578–588.
30. Wu LP, Ficker M, Christensen JB, Trohopoulos PN, Moghimi SM*. (2015). Dendrimers in Medicine: Therapeutic Concepts and Pharmaceutical Challenges. Bioconjugate chemistry，26(7), 1198-1211.
31. Wu LP, Wang DY, Parhamifar L, Hall A, Chen G-Q, Moghimi, SM*. (2014). Poly (3-hydroxybutyrate-co-R-3-hydroxyhexanoate) Nanoparticles with Polyethylenimine Coat as Simple, Safe, and Versatile Vehicles for Cell Targeting: Population Characteristics, Cell Uptake, and Intracellular Trafficking. Advanced healthcare materials, 3(6), 817-824.
32. Wu LP#, You ML#, Wang DY, Peng GF, Wang ZH, CHEN G-Q*. (2013). Fabrication of Carbon Nanotubes (CNTs)/Poly(3-hydroxyburyrate-co-3-hydroxyhexanoate) (PHBHHx) Nanocomposite Films for Human Mesenchymal Stem Cells (hMSCs) Differentiation. Polymer Chemistry, 4, 4490-4498
33. Tripathi L#, Wu LP#, Chen JC, Chen G-Q*. (2012).Synthesis of diblock copolymer poly-3-hydroxybutyrate-block-poly-3-hydroxyhexanoate [PHB-b-PHHx] by a beta-oxidation weakened Pseudomonas putida KT2442. Microbial Cell Factories, 11:44.
34. Wu LP, Wang XJ, Cheng ST, Xu KT*. (2010). Synthesis, characterizations and biocompatibility of novel biodegradable star block copolymers based on poly[(R)-3-hydroxybutyrate] and poly(ε-caprolactone). Acta Biomaterialia, 6, 1079-1089
35. Wu LP, Cheng ST, Li ZB, Chen G-Q*, Xu KT*. (2008). Synthesis, characterization and biocompatibility of novel biodegradable poly[((R)-3-hydroxybutyrate)-block-(D,L-lactide)- block-(ε-caprolactone)] triblock copolymers. Polymer International, 57, 939-949.