|
2024 - Present |
Guangzhou Institutes of Biomedicine and Health at Chinese Academy of Sciences, PI |
|
2019 - 2024 |
School of Life Sciences at South China Normal University, Professor |
|
2017 - 2019 |
School of Life Sciences at The University of Chicago, Instructor |
|
2012 - 2017 |
School of Life Sciences at The University of Chicago, Postdoctoral scholar |
|
2007 - 2012 |
Zhongshan School of Medicine of Sun Yat-sen University, PhD |
|
2002 - 2007 |
School of Medicine at Anhui University of Science and Technology, Bachelor |
My recent research interests focus on the mechanisms underlying host-microbe interactions in physiological and pathological conditions. I received my PhD in 2012 at Sun Yat-sen University studying pathogen biology, then I finished my postdoctoral training in Prof. Tao Pan’s lab at the University of Chicago from 2012 to 2017, I was promoted to be Independent Instructor at the University of Chicago in 2017 after I received the NIH K award. I came back to China and take a full professor position at South China Normal University in 2019. In 2024, I moved to Guangzhou Institutes of Biomedicine and Health at Chinese Academy of Sciences as a principal investigator. I have published more than 60 papers in Nature Chemical Biology, Genome Research, Cell Research, Cell Reports, Advanced Science, Genome Biology, PLoS Genetics, etc. I am the first or corresponding author in 30 of these publications.
32070615 (PI: Xiaoyun Wang), National Natural Science Foundation of China
01/01/21-12/31/2024
Funding Title: Study on the role of gut microbiota in regulating host mRNA methylation
81902093 (PI: Xiaoyun Wang), National Natural Science Foundation of China
01/01/20-12/31/2022
Funding Title: Study on the role of gut microbiota in regulating host tRNA methylation in mosquito
2021A1515010823 (PI: Xiaoyun Wang), Guangdong Natural Science Foundation of China
01/01/2022-12/31/2024
Funding Title: The role of gut microbiota metabolite folic acid in regulating mouse RNA methylation and organ development
2021A1515010823 (PI: Xiaoyun Wang), Guangdong Natural Science Foundation of China
01/01/2021-12/31/2023
Funding Title: The role of gut microbiota in regulating Drosophila host mRNA m6A
2024A04J6265 (PI: Xiaoyun Wang), Guangzhou Science and Technology Project of China
01/01/2024-12/31/2026
Funding Title: The role of epigenetics in host-gut microbiota interactions
1K01DK111764-01A1 (PI: Xiaoyun Wang), NIDDK at United States National Institutes of Health
08/04/17-7/31/2019
Funding Title: Regulation through gut microbiome-derived queuosine tRNA modification
1. Zihe Xu#, Xiaoqi Zheng#, Jiajun Fan#, Yuting Jiao, Sihao Huang, Yingyuan Xie, Shunlan Xu, Yi Lu, Anrui Liu, Runzhou Liu, Ying Yang, Guan-Zheng Luo, Tao Pan, Wang X*. Microbiome-induced reprogramming in post-transcriptional landscape using Nanopore direct RNA sequencing. (Cell Reports, in press).
2. Yang M#, Zheng X#, Fan J#, Cheng W#, Yan TM, Lai Y, Zhang N, Lu Y, Qi J, Huo Z, Xu Z, Huang J, Jiao Y, Liu B, Pang R, Zhong X, Huang S, Luo GZ, Lee G, Jobin C, Eren AM, Chang EB, Wei H*, Pan T*, Wang X*. Antibiotic-induced gut microbiota dysbiosis modulates host transcriptome and m6A epitranscriptome via bile acid metabolism. Advanced Science. 2024, 11(28):e2307981.
3. Huang J#, Chen W#, Zhou F, Pang Z, Wang L, Pan T, Wang X*. Tissue-specific reprogramming of host tRNA transcriptome by the microbiome. Genome Research. 2021, 31(6):947-957.
4. Wang X#, Li Y#, Chen W, Shi H, Eren AM, Morozov A, He C, Luo GZ*, Pan T*. Transcriptome-wide reprogramming of N6-methyladenosine modification by the mouse microbiome. Cell Research. 2019, 29(2):167-170.
5. Ma H#, Wang X#, Cai J#, Dai Q, Natchiar SK, Lv R, Chen K, Lu Z, Chen H, Shi YG, Lan F, Fan J, Klaholz BP, Pan T*, Shi Y*, He C*. N6-methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. Nature Chemical Biology. 2019, 15(1):88-94.
6. Wang X, Chen W, Huang Y, Sun J, Men J, Liu H, Luo F, Guo L, Lv X, Deng C, Zhou C, Fan Y, Li X, Huang L, Hu Y, Liang C, Hu X, Xu J, Yu X*. The draft genome of the carcinogenic human liver fluke Clonorchis sinensis. Genome Biology. 2011, 12(10):R107.
7. Wang X*, Pan T*. Methionine mistranslation bypasses the restraint of the genetic code to generate mutant proteins with distinct activities. PLOS Genetics. 2015, 11(12):e1005745.
8. Liu X#, Yang M#, Liu R, Zhou F, Zhu H*, Wang X*. The impact of Parkinson's disease-associated gut microbiota on the transcriptome in Drosophila. Microbiology Spectrum. 2023 Sep 27;e0017623.
9. Huang J#, Zhou F#, Zhou H, Zheng X, Huo Z, Yang M, Xu Z, Liu R, Wang L, Wang X*. Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging. PNAS Nexus. 2023 Dec 5;2(12):pgad390.
10. Zhou F#, Liu B#, Liu X, Li Y, Wang L, Huang J, Luo G*, Wang X*. The impact of microbiome and microbiota-derived sodium butyrate on Drosophila transcriptome and metabolome revealed by multi-omics analysis. Metabolites. 2021 May 6;11(5):298.