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2022 – present |
Principal Investigator. Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (CAS) |
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2016 – 2022 |
Postdoctoral Research Fellow. Supervised by Prof Jesper Svejstrup, FRS, FMedSci, The Francis Crick Institute, London, the United Kingdom |
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2015 – 2016 |
Research Assistant. Supervised by Prof Jun Huang, The Life Sciences Institute, Hangzhou, Zhejiang University, China |
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2010 – 2015 |
PhD. Supervised by Prof Jun Huang, The Life Sciences Institute, Zhejiang University, Hangzhou, China |
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2006 – 2010 |
BSc. College of Life Sciences, Northwest A&F University, Xi’an, China |
I started my Ph.D. studies in Professor Huang Jun’s laboratory at the School of Life Sciences, Zhejiang University, where I focused on the molecular mechanisms of DNA damage repair using cell biology techniques. I later joined Jesper Svejstrup’s laboratory (Fellow of the Royal Society and Academy of Medical Sciences) at the Francis Crick Institute in the UK for postdoctoral research. During this time, I also visited Manu Hegde’s laboratory (Fellow of the Royal Society) at the University of Cambridge to study the molecular mechanisms related to innate immune response and protein synthesis. In October 2022, I established my research group at the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences. My team adopts a multidisciplinary approach integrating cell biology, molecular biology, biochemistry, and immunology. We employ innovative techniques such as in vitro translation, quantitative proteomics, CRISPR-mediated gene knockout, ribosome analysis, and cryo-electron microscopy to systematically study the molecular mechanisms of innate immune response and protein synthesis. I have received the Zhejiang Natural Science First Prize and the EMBO Long-Term Fellowship.
• 2013: National Scholarship for Doctoral Students
• 2015: Outstanding Graduate of Zhejiang University
• 2016: EMBO Long-Term Fellowship
• 2017: Zhejiang Natural Science First Prize (third contributor)
1. Wan Li, Szymon Juszkiewicz, Daniel Blears, Prashanth Kumar Bajpe, Zhong Han, Peter Faull, Richard Mitter, Ambrosius Snijders, Aengus Stewart, Ramanujan S. Hegde, and Jesper Q. Svejstrup. (2021) Translation Stress and Collided Ribosomes are Co-activators of cGAS. Molecular Cell, 81(13):2808-2822.
2. Jinhua Han*, Wan Li*, Guixing Jiang, Liping Cao, Tian Tian, Feiyu Xia, Yi Luo, Yi Wang, Michael S.Y. Huen, Ting Liu, and Jun Huang. (2021) ATM Controls the Extent of DNA End Resection by Eliciting Sequential Posttranslational Modifications of CtIP. Proceedings of the National Academy of Sciences USA (*Co-First Author).
3. Wan Li and Jun Huang. (2014) The PSO4 Complex Associates with RPA and Modulates the Activation of ATR. Journal of Biological Chemistry, 289:6619-6626.
4. Wan Li*, Jiangman Lou*, Yisui Xia*, Bei Su, Ting Liu, Jiamin Cui, Yingying Sun, Huiqiang Lou, and Jun Huang. (2013) hPrimpol1/CCDC111 is a Human DNA Primase-Polymerase Required for the Maintenance of Genome Integrity. EMBO Reports, 14:1104-1112 (*Co-First Author).
5. Wan Li*, Jinhua Han*, Ting Liu*, Shunli Dong, Feng Xie, Hongxia Chen, and Jun Huang. (2013) Scaffolding Protein SPIDR/KIAA0146 Connects the Bloom Syndrome Helicase with Homologous Recombination Repair. Proceedings of the National Academy of Sciences USA, 110:10646-10651 (*Co-First Author).
6. Ting Liu*, Wan Li*, Yue Wu, Junjie Chen, and Jun Huang. (2011) hSWS1-SWSAP1 is an Evolutionarily Conserved Complex Required for Efficient Homologous Recombination Repair. Journal of Biological Chemistry, 286:41758-41766 (*Co-First Author).