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2017 – now |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences (CAS) / Deputy Director, Professor |
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2013 – 2017 |
Bureau of Science &Technology for Development, CAS / Deputy Director, Professor |
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2010 – 2013 |
Agriculture Program Office, CAS / Executive Director, Professor |
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2007 – 2010 |
Biology Bureau, CAS / Professor |
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2006 – 2007 |
Modern Agricultural Innovation Office, Biology Bureau, CAS / Director, Associate professor |
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2003 – 2005 |
Environmental Biology and Biotechnology Department, Biology Bureau, CAS / Deputy Director, Associate professor |
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2004 – 2005 |
University of Nebraska Medical Center / Senior Visiting Scholar |
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2002 – 2003 |
Agrobiology and Biotechnology Department, Biology Bureau, CAS / Business Supervisor |
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2000 – 2002 |
Institute of Genetics and Developmental Biology, CAS/ Postdoctoral fellow |
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1998 – 2000 |
Department of Animal Science, Gansu Agricultural University / Associate Professor |
The research group focused on mechanistic studies of latent infection and reactivation of Epstein-Barr virus (EBV) within the spectrum of cytopathology and immunometabolics. For this purpose, the group has established a new method for immortalizing human lymphocytes to create cell lines for chronic active lymphocytosis (CAEBV) and hemophagocytosis (HLH) infected by EBV, and has established T and NK cell lines derived from CAEBV patients. We have conducted interactomics research on the interaction between LMP1 and host factors through immunoprecipitation and mass spectrometry analysis. It was discovered that EBV latent membrane protein 1 (LMP1) promotes the degradation of the RIG-I signaling pathway and inhibits the secretion of interferon β via the proteasome pathway. The group has identified microRNA that plays a major regulatory role and is resolving the mechanism of virus establishment and maintenance of latent infection, as well as screening for drugs to activate virus reservoirs and facilitate clearance. Considering the important role of adipocytes in EBV infection and inflammation, the mechanism of short-chain fatty acid metabolism and its cooperation with the intestinal microbiota in animals were analyzed. Additionally, the immortal cell bank of the Chinese nation has been established and improved by using the mechanism of EB virus to transfect lymphoid B cells in vitro, and the information management and quality control system of the cell bank have been established and improved, either.
( 1 ) A human NK / T cell line, null, 2018, 1st author, Patent No.: CN108220237A
( 2 ) A method for establishing an NK and/or T cell line, invention patent, 2018, No. 1 Author, Patent No.: CN108251368A
( 3 ) The high efficiency swine constitutive promoter and its application, Patent of invention, 2016, No.1 Author, Patent No.: CN105779455A
(1) Breeding of New Lean Lines of Gansu White Pigs, First Prize, Provincial Level, 1998
(2) Construction of Off-campus Teaching and Practical Bases, Third Prize, Ministerial Level, 1992
1. Wang, X.;Hao W.; Huang X.; Duan, Z*. Lower blood lipid level from the administration of plant tannins via altering the gut microbiota diversity and structure. Food Funct. 2023 22;14(10):4847-4858.
2. Ai S, Zhang Z, Wang J, Wang X, Liu C, Duan Z*. Prevalence and molecular identification of gastrointestinal nematodes in Qinghai-Tibetan Plateau of China. Vet Med Sci. 2023;9(6):2693-2702.
3. Wang X.; Zhang Z.; Li B.;Hao W.;Yin W.; Ai S.; Han J.; Wang R.; Duan Z*. Depicting Fecal Microbiota Characteristic in Yak, Cattle, Yak-Cattle Hybrid and Tibetan Sheep in Different Eco-Regions of Qinghai-Tibetan Plateau. Microbiol Spectr., 2022 31;10(4):e0002122.
4. Tao Z.; Ding W.;Cheng Z.; Feng Y.;Kang Z.; Qiu R.;Zhao S.; Hu W.;Zhou F.;Wu D.;Duan Z*.; Qin L*.; Chen X*. Preclinical Study of Plasmodium Immunotherapy Combined with Radiotherapy for Solid Tumors. Cells, 2022, 11, 3600.
5. Li L.;Wan Q.;Long Q.;Tao N.;Zhao S.;Mao L.,Cheng C.;Zou C.; Loomes K.;Xu A.;Lai L.;Liu X.; Duan Z*.; Hui X*.; Wu D*. Comparative transcriptomic analysis of rabbit interscapular brown adipose tissue whitening under physiological conditions. Adipocyte. 2022 Dec;11(1):529-549.
6. Zhang Z.; Liu C.; Hao W.; Yin W.; Ai S.; Zhao Y.; Duan Z*. Novel Single Nucleotide Polymorphisms and Haplotype of MYF5 Gene Are Associated with Body Measurements and Ultrasound Traits in Grassland Short-Tailed Sheep. Genes (Basel). 2022 Mar 9;13(3):483.
7. Wang, X.; Zhang, Z.; Wang, X.; Bao, Q.; Wang, R.; Duan, Z*. The Impact of Host Genotype, Intestinal Sites and Probiotics Supplementation on the Gut Microbiota Composition and Diversity in Sheep. Biology 2021, 10, 769.
8. Ai S, Zhang Z, Wang X, Zhang Q, Yin W, Duan Z*. The first survey and molecular identification of Entamoeba spp. in farm animals on Qinghai-Tibetan Plateau of China. Comp Immunol Microbiol Infect Dis. 2021,75:101607.
9. Zhang Q.; Yin W.; Wang X.; Zhang Z.; Zhang R.Duan Z*. Blastocystis infection and subtype distribution in domestic animals in the Qinghai-Tibetan Plateau Area (QTPA) in China: A preliminary study，Parasitology International, 2021, 81:102272.
10. Zhang Q.; Luo D.; Xie Z*.; He H*.; Duan Z*.The oncogenic role of miR-BART19-3p in Epstein-Barr virus associated diseases, BioMed Research International,2020, 2,Article ID 5217039.
11. Zhang Q.; Zhang Z.; Ai S.; Wang X.; Zhang R.; Duan Z*. Cryptosporidium spp., Enterocytozoon bieneusi, and Giardia duodenalis from animal sources in the Qinghai-Tibetan Plateau Area (QTPA) in China,Comp Immunol Microbiol Infect Dis. 2019;67:101346.
12. Xu C.; Sun L.; Liu W.; Duan Z*.Latent membrane protein 1 of Epstein-Barr Virus promotes RIG-I degradation mediated by proteasome pathway, Frontiers in Immunology,2018, 9:1446.
13. Xu C, Ai J, Zhang Q, Li T, Wu X, Xie Z, Duan Z.*，An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection，J Vis Exp. 2018 30(133).
14. Bao Q, Li C, Xu C, Zhang R, Zhao K, Duan Z.*，Porcine enterocyte protein Btnl5 negatively regulates NF-kappa B pathway by interfering p65 nuclear translocation，Gene, 2017，29：pii: S0378-1119(17) 31035 -1.
15. Liu W, Li J, Zheng W, Shang Y, Zhao Z, Wang S, Bi Y, Zhang S, Xu C, Duan Z, Zhang L, Wang YL, Jiang Z, Liu W, Sun L, Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses, Elife,2017, 8;6. pii: e24425.
16. Zhang R, Xu C, Duan Z. *，Novel antigenic shift in HA sequences of H1N1 viruses detected by big data analysis, Infect Genet Evol., 2017,51:138-142.
17. Liu X, Xu C, Duan Z.*，A Simple Red Blood Cell Lysis Method for the Establishment of B Lymphoblastoid Cell Lines, J Vis Exp., 2017, 14(119).
18. Xu C, Duan Z*. The development of Chinese population genetics by Ruofu Du.，Protein Cell. 2017 Jan;8(1):1-3.