Faculty
ZHANG Xiao Christopher
Title:Group Leader
Subject:
Email:zhang_xiao@gibh.ac.cn
Address:190 Kaiyuan Avenue, Guangzhou Science Park, Huangpu District, Guangzhou
Study/Work Experience

2013 – now

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Principal Investigator, Head of Applied Stem Cell Automation Research, Director for China Southern Territory for CAS equipment center

2010 – 2013

DANAHER/ Product Development Manager, Biotherapeutics, Genetix, MolDev

2009 – 2010

DANAHER/ Scientist – R&D Biology, Biotherapeutics, Genetix, Leica Microsystems

2007 – 2009

Department of Cardiovascular Research, NHS, Royal Hallamshire Hospital/ Pre-clinical Research Fellow

2005 – 2008

Medical School, Royal Hallamshire Hospital/ Ph.D, Immunology and Cell Biology

Research Areas

Molecular Tissue Biology, ECM Regulation of Cell Fate, Life Science Instrument Development, Organ Regeneration, and 3D Printing.

Academic Performance

2013 "Outstanding Technical Talents Introduction Program" by the Chinese Academy of Sciences

2019 Zhu Liangyi "Youth Innovation Award" from the Chinese Instrument and Control Society


(1)A system and method for calibrating sensor measurements in a biological incubator, invention patent, 201410058969.4, first inventor.

(2)An active water and heat supply device and method for a biological incubator, invention patent, 201410060573.3, first inventor.

(3)A container sealing structure and sealing bottle, invention patent, 201410141123.7, first inventor.

(4)An image edge detection method and system, invention patent, 201410314122.8, other.

(5)A multi-layer image fusion algorithm for bright field microscopic imaging, invention patent imaging, invention patent, 201510416230.0, other.

(6)A light path switching device for a fluorescence microscope, invention patent, 201510416247.6, other.

(7)A microscope system for longitudinal scanning, invention patent, 201510416232.X, other.

(8)A cell acquisition needle, invention acquisition needle, invention patent, 201610036853.X, other.

(9)An automatic capping and decapping device, invention patent, 201610362560.0, other.

(10)An automatic needle washing device and method, invention device and method, invention patent, 201610369456.4, other.

(11)A cell culture chamber, invention patent, 201510391262.X, other.

(12)An intelligent robotic arm and a method for automatically controlling automatically controlling a culture chamber component, invention patent, 201510391328.5, other.

(13)A biological tissue permeabilization device, invention patent, 201510, invention patent, 201510391330.2, other.

(14)A culture chamber and a method for automatically opening and closing the chamber door, invention patent, 201 door, invention patent, 201510439578.1, other.

(15)An automatic focusing device and method, invention patent and method, invention patent, 201510439170.4, first inventor.

(16)An automatic focusing device and method, invention device and method, invention patent, 201510439576.2, first inventor.

(17)A light sheet microscope, invention patent microscope, invention patent, 201810047840.1, first inventor.

(18)A phase recovery method, device, and system, invention, device, and system, invention patent, 201810077989.4, first inventor.

(19)An imaging device, invention patent, 201810077991.1, first inventor.

(20)A fluorescence detection. A fluorescence detection device and system, invention patent, 202010717240.9, first patent, 202010717240.9, first inventor.

(21)A rapid structured illumination super-resolution microscope, invention patent, application number 202011079423.9, first inventor.

(22) A super-resolution microscope, invention patent, application number 201910624895.9, first inventor.

(23) A method and equipment for 3D light curing, invention patent, application number 201910729976.5, first inventor.


Representative Papers

1Chen, X.; Fan, K.; Lu, J.; Zhang, S.; Dong, J.; Qin, J.; Fan, W.; Wang, Y.; Zhang, Y.; Peng, H.; Zhang, Z.; Sun, Z.; Yu, C.; Xiong, Y.; Song, Y.; Ye, Q.; Mai, S.; Wang, Y.; Wang, Q.; Zhang, F.; Wen, X.; Zhou, T.; Han, L.; Long, M.; Pan, G.; Burke, J. F.; Zhang, X., Selecting Monoclonal Cell Lineages from Somatic Reprogramming Using Robotic-Based Spatial-Restricting Structured Flow. Research (Wash D C) 2024, 7, 0338.

2Yu, C. L.; Zhang, M.; Xiong, Y. C.; Wang, Q. Z.; Wang, Y. H.; Wu, S. L.; Hussain, S.; Wang, Y.; Zhang, Z. Z.; Rao, N.; Zhang, S.; Zhang, X., Comparison of miRNA transcriptome of exosomes in three categories of somatic cells with derived iPSCs. Sci Data 2023, 10 (1).

3Sheng zhang; man zhai; yiwei xu; jiandong han; jiaxin chen; yucui xiong; shihua pan; qizheng wang; chunlai yu; zilong rao; qi sun; yufei sui; ke fan; heying li; wenjing guo; cuicui liu; ying bai; jing zhou; daping quan; xiao zhang ; Decellularised spinal cord matrix manipulates glial niche into repairing phase via serglycin-mediated signalling pathway, cell proliferarion, 2023, 0(0)

4Zeping Gao; Shuo Wang; Yufei Sui; Qi Zhang; Ye Yang; Jiqing Huang; Yucui Xiong; Teng Ma; Xiao Zhang; Hairong Zheng ; A Multifunctional Acoustic Tweezer for Heterogenous Assembloids Patterning, Small Structures, 2023.

5Qizheng Wang; Jun Lu; Ke Fan; Yiwei Xu; Yucui Xiong; Zhiyong Sun; Man Zhai; Zhizhong Zhang; Sheng Zhang; Yan Song; Jianzhong Luo; Mingliang You; Meijin Guo; Xiao Zhang ; High-throughput read-on-ski automated imaging and label-free detection system for toxicity screening of compounds using personalised human kidney organoids, Journal of Zhejiang University-science B, 2022, 23(7): 564-577

6Jun Lu; Weihua Fan; Zihui Huang; Ke Fan; Jianhua Dong; Jisheng Qin; Jianzhong Luo; Zhizhong Zhang; Guodong Sun; Chaohui Duan; Kunyi Pan; Wenshen Gu; Xiao Zhang ; Automatic system for high-throughput and high-sensitivity diagnosis of SARS-CoV-2, Bioprocess Biosyst Eng., 2022, 1-12

7Yiwei Xu; Jing Zhou; Cuicui Liu; Sheng Zhang; Fenglin Gao; Wenjing Guo; Xiumin Sun; Chi Zhang; Heying Li; Zilong Rao; Shuai Qiu; Qingtang Zhu; Xiaolin Liu; Xiaodong Guo; Zengwu Shao; Ying Bai; Xiao Zhang; Daping Quan ; Understanding the role of tissue-specific decellularized spinal cord matrix hydrogel for neural stem/progenitor cell microenvironment reconstruction and spinal cord injury, Biomaterials, 2021, 268: 120596

8Chunlai Yu; Mingliang You; Peizhen Zhang; Sheng Zhang; Yuzhu Yin; Xiao Zhang ; A fivegene signature is a prognostic biomarker in pancancer and related with immunologically associated extracellular matrix, Cancer Medicine, 2021, 10(13): 4629-4643

9Qizheng Wang; Yucui Xiong; Sheng Zhang; Yufei Sui; Cunlai Yu; Peng Liu; Heying Li; Wenjing Guo; Yubo Gao; Aneta Przepiorski; Alan J. Davidson; Meijin Guo; Xiao Zhang ; The Dynamics of Metabolic Characterization in iPSC-Derived Kidney Organoid Differentiation via a Comparative Omics Approach, Frontiers in Genetics, 2021, 12: 632810

10Wen, Shaoqing; Sun, Chang; Zheng, Huanying; Wang, Lingxiang; Zhang, Huan; Zou, Lirong; Liu, Zhe; Du, Panxin; Xu, Xuding; Liang, Lijun; Peng, Xiaofang; Zhang, Wei; Wu, Jie; Yang, Jiyuan; Lei, Bo; Zeng, Guangyi; Ke, Changwen; Chen, Fang; Zhang, Xiao ; High-coverage SARS-CoV-2 genome sequences acquired by target capture sequencing, JOURNAL OF MEDICAL VIROLOGY, 2020, 92(10): 2221-2226

11Wei Sun; Sheng Zhang; Tiancheng Zhou; Yongli Shan; Fenglin Gao; Ying Zhang; Di Zhang; Yucui Xiong; Yuanbang Mai; Ke Fan; Alan J. Davidson; Guangjin Pan; Xiao Zhang ; Human Urinal Cell Reprogramming: Synthetic 3D Peptide Hydrogels Enhance Induced Pluripotent Stem Cell Population Homogeneity, ACS Biomaterials Science & Engineering, 2020, 6: 6263-6275

12Yang, Zehong; Zheng, Chushan; Zhang, Fang; Lin, Binglin; Cao, Minghui; Tian, Xuwei; Zhang, Jingzhong; Zhang, Xiao; Shen, Jun ; Magnetic resonance imaging of enhanced nerve repair with mesenchymal stem cells combined with microenvironment immunomodulation in neurotmesis, MUSCLE & NERVE, 2020, 61(6): 815-825

13Ke Fan; Sheng Zhang; Ying Zhang; Jun Lu; Mike Holcombe; Xiao Zhang ; A Machine Learning Assisted, Label-free, Non-invasive Approach for Somatic Reprogramming in Induced Pluripotent Stem Cell Colony Formation Detection and Prediction., Scientific Reports, 2017, 7: 13496

14Songwei He; Jinlong Chen; Yixin Zhang; Mengdan Zhang; Xiao Yang; Yuan Li; Hao Sun; Lilong Lin; Ke Fan; Lining Liang; Chengqian Feng; Fuhui Wang; Xiao Zhang; Yiping Guo; Duanqing Pei; Hui Zheng ; Sequential EMT-MET induces neuronal conversion through Sox2, Cell Discovery, 2017, 3: 17017-17017

15Neilan.M; Zhang.X; Steiner.T; Boyle.J; Francis.S; Haskard.D; Qwarnstrom.E ; TILRR Functional Mutants Selectively Inhibit Inflammatory and Anti-Apoptotic Responses., Heart. 12, 2012, 98(10): 6

16 Xiao Zhang; Gemma Montagut Pino; Freya Shephard; Endre Kiss-Toth; Eva E.Qwarnstrom ; Distinct Control of MyD88 Adapter-dependent and Akt Kinase-regulated Responses by the Interleukin (IL)-1RI Co-receptor, TILRR, Journal of Biological Chemistry, 2012, 287(15): 12348-12352

17Xiao Zhang; Freya Shephard; Hong B. Kim; Ian R. Palmer; Selina McHarg; Gregory J. S. Fowler; Luke A. J. ONeill; Endre Kiss-Toth; Eva E. Qwarnstrom ; TILRR, a novel IL-1RI co-receptor, potentiates MyD88 recruitment to control Ras-dependent amplification of NF-kappaB, The Journal of biological chemistry., 2010, 285(10): 7222-7232