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2010 – now |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/Professor |
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2007 – 2010 |
Thomas Jefferson University/Research fellow |
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2002 – 2006 |
Tsinghua University/Ph.D. (Biology) |
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1998 – 2002 |
Shandong University/Bachelor (Biotechnology) |
(1) Organelle remodeling and metabolic controlling in cell fate determination
(2) Mechanisms of mitochondrial diseases and therapy by stem cells
Professor Xingguo Liu, was honored as “Distinguish Youth Foundation” of National Natural Science Foundation, Chief Scientist of the National Key Research and Development Program of China, 1st finisher of the first prize of the Guangdong Science and Technology Award in Natural Science, The Shulan Medicine Youth Award by the Academician Shusen Lanjuan Talent’ Foundation, The Ying Ding Science and Technology Award, “2016 Stem cell Young Investigator Award” from Chinese Society for Cell Biology and “Young Bioenergeticist Award” of the International Biophysical Society. He is the Executive Editor of Science Bulletin, the council member of the Asian Society for Mitochondrial Research and Medicine, and the council member of the Biophysical Society of China. Dr. Liu has published more than 80 papers, which have been cited for more than 6000 times. Since 2015, he has published 32 research papers as corresponding author (4 IF>20, 22 IF>9), such as Cell Metabolism (2016,2018, 2024), Nature Metabolism, Nature Structural & Molecular Biology, Nature Communications (2022,2024), Science Advances (2019, 2022), Advanced Science, Hepatology. Among his papers, 3 were recommended by F1000, 9 were chosen as cover, and his findings have been listed in 17 books such as Encyclopedia of Biological Chemistry. He obtained 10 authorized patents (including one PCT). Dr. Liu has been the invited speaker in Keystone Symposia.
Editor of Science Bulletin, FASEB Journal, Life Metabolism, MedComm
Council member of the Asian Society for Mitochondrial Research and Medicine
Council member of the Biophysical Society of China
Vice Chairman, Mitochondrial Biology Branch, the Biophysical Society of China
Vice Chairman, the Stem Cell Engineering Technology Branch, the Biomedical Engineering Society of China
2020 “Distinguish Youth Foundation” of National Natural Science Foundation
2018 Chief Scientist of the National Key Research and Development Program of China
2020 1st finisher of the first prize of the Guangdong Science and Technology Award in Natural Science
2021 Shulan Medicine Youth Award by the Academician Shusen Lanjuan Talent’ Foundation
2023 Ying Ding Science and Technology Award
2011 “2011 Young Bioenergeticist Award” from International Biophysical Society (One per year)
2016 “Yangtse River Scholar” Bonus Schemes
2016 “Outstanding Youth Foundation” of China of National Natural Science Foundation
2016 “Stem cell Young Investigator Award” from Chinese Society for Cell Biology
2016 “Science and Technology Innovation Leading Talents” of Guangdong
2012 Natural Science Funds for “Distinguished Young Scientists” of Guangdong
2011 “One Hundred Talents Program” of Chinese Academy of Sciences, and selectively supported
1. Hu, Z., Yang, L., Zhang, M.,…Liu, X*. (2024). A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development. Cell Metabolism, 36(7):1586-1597.e7. (Preview by Cell Metabolism)
2. Ying, Z., Xiang G., Zheng, L., …Liu, X*. (2018). Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming. Cell Metabolism, 28(6):935-945.
3. Ying, Z., Chen K., Zheng, L., …Liu, X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism, 23(1):220-226.
4. Li, L., Chen, K., Wang, T., …Liu, X*. (2020). Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism 2(9):882-892.
5. Long, Q., Zhou, Y., Wu, H., …Liu, X*. (2021). Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation. Nature Structural & Molecular Biology 28(11):900-908.
6. Li, W., Long, Q., Wu, H., …Liu, X*. (2022). Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation. Nature Communications, 13(1):7414. (IF= 16.6) (Editors’ Highlights)
7. Yang, L., Ruan, Z., Lin, X., …Liu, X*. (2024). NAD+ dependent UPRmt activation underlies intestinal aging caused by mitochondrial DNA mutations Nature Communications , 15: 546
8. Bao, F., Zhou, L., Zhou, R., …Tian, M*&Liu, X*. (2022). Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances, 8(15):eabk2376.
9. Wu, Y., Chen, K., Xing, G., …Liu, X*. (2019). Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances, 5(11):eaax752.
10. Guo, J., Duan, L., He, X., …Liu, X*. (2021). A combined model of human iPSC-derived liver organoids and hepatocytes reveals ferroptosis in DGUOK mutant mtDNA depletion syndrome. Advanced Science 8(10):2004680. (Cover)
11. Li, S., Guo, J., Ying, Z., ... Liu, X*. (2015). Valproic acid‐induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening‐dependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5):1730-1739.
12. Chen, K., Long, Q., Xing, G., …Pei, D*& Liu, X*. (2020). Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO Journal, 39(1):e99165 (F1000)
13. Liao, R., Wu, Y., Le, Q., … Liu, X* & Li, P*. (2023). BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells. EMBO Journal, 2023 Nov 2;42(21):e113448.
14. Xiang, G., Yang, L., Long, Q., …Liu, X*. (2017). BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. Autophagy, 13(9):1543-1555.
15. Zhou, Y., Long, Q., Wu, H., …Liu, X*. (2020). Topology-dependent, bifurcated mitochondrial quality control under starvation. Autophagy, 16(3):562-574. (Cover)
16. Wu, Y., Chen, K., Li L., …Liu, X*. (2022). Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation. Cell Death & Differentiation, 29(11):2316-2331.
17. Xing, G., Liu, Z., Huang L., …Pei, D* Liu, X* & Chen, K*. (2022). MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. Cell Death & Differentiation, 29(5):1042-1054.
18. Yao, D., Li, Y., Zeng, S., …Liu, X*. (2022). Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space. Science China-Life Sciences, 65(2):227-235. (Cover).
19. Wang, R., Bao, F., Lu, M., …Zhang, Q.*, Liu, X*. (2024). MSC-mediated mitochondrial transfer restores mitochondrial DNA and function in neural progenitor cells of Leber's Hereditary Optic Neuropathy. Science China-Life Sciences, Aug 08, 2024 https://doi.org/10.1007/s11427-024-2647-8.