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2020 – now |
GuangZhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Principal Investigator |
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2009 – 2020 |
Institute Pasteur of Shanghai, Chinese Academy of Sciences/ Principal Investigator |
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2005 – 2009 |
Medical College of Wisconsin, USA /Postdoctoral fellow |
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1999 - 2005 |
Kunming Institute of Zoology, Academy of Sciences/PhDDuke University Medical Center/Assistant Professor (Tenure Track) |
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1995 – 1999 |
Henan University School of Life Sciences/ B.S. |
Dr. Jian-Hua Wang is a Professor in Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS). Before joining GIBH, Dr. Wang was a Professor/Principal Investigator at the Institute Pasteur of Shanghai, CAS. The research field of Dr. Wang is the interaction of virus-host to understand viral pathogenesis: 1) Host modulation of HIV-1 latency, and antiviral drug development; 2) Uncovering immune-pathogenesis by studying the acute viral infection-induced hyper-inflammation. He has published over 100 manuscripts in peer reviewed journals including Signal Transduct Target Ther, Nucleic Acids Res, mBio(3), J Med Chem (2), and J Virol (6), etc.
Targeting the key and fundamental scientific questions in HIV/AIDS field, Wang`s lab focuses on: 1) to reveal the novel mechanism of HIV transmission in acute infection; 2) to reveal mechanism of the establishment, maintenance and reactivation of HIV latency; 3) to develop therapeutic approaches for latency eradication. Regarding to the emerging viruses, Wang`s lab extends to uncover the invasion mechanisms, and viral pathogenesis, and develop strategies for prevention and control. The main achievements include:
1. Uncovering the new mechanisms for HIV/retrovirus mucosal invasion, and develop new strategies for prevention;
2. Identifying the key host factors that modulates HIV-1 transmission, replication and latency, which provides potential targets for therapy.
3. He has published more than 50 scientific papers in journals, such as NUCLEIC ACID RES., MBIO, J VIROLOGY, etc.
1. Qu D, Sun WW, Li L, Ma L, Sun L, Jin X, Li T*, Hou W*, Wang JH*. Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter. Nucleic Acids Res, 2019, PMID: 30788509.
2. Zhou YH, Sun L, Chen J, Sun WW, Ma L, Han Y, Jin X, Zhao QX, Li T, Lu H, Qiu X*, Wang JH*. Tryptophan Metabolism Activates Aryl Hydrocarbon Receptor-Mediated Pathway to Promote HIV-1 Infection and Reactivation. mBio, 2019. PMID:31848275.
3. Sun WW, Jiao S, Sun L, Zhou Z, Jin X, Wang JH*. SUN2 modulates HIV-1 infection and latency through association with lamin A/C to maintain the repressive chromatin. mBio, 2018. PMID: 29717016.
4. Ma L, Jiang QA, Sun L, Yang X, Huang H, Jin X, Zhang C, Wang JH*. X-linked RNA-binding Motif Protein modulates HIV-1 infection of CD4+ T cells by maintaining the tri-methylation of histone H3 lysine 9 at the downstream region of the 5′ long terminal repeat of HIV proviral DNA. mBio, 2020, PMID: 32317327.
5. Jiang AP, Jiang JF, Wei JF, Guo MG, Qin Y, Guo QQ, Ma L, Liu BC, Wang X, Veazey RS, Ding YB*, Wang JH*. Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells. J Virol. 2015. PMID:26719250