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2018 – now |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences,China/Researcher Follow |
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2013 – 2017 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences,China/Associate Professor |
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2007 – 2012 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences,China/Ph.D |
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2003 – 2007 |
Hubei University, China/Bechelor |
Dr. Liu Jing is a leading researcher specializing in stem cell biology and cellular fate regulation. His work primarily focuses on understanding the molecular mechanisms of stem cell pluripotency, creating animal disease models using pluripotent stem cells, and investigating cellular chimerism. He has contributed to numerous high-impact international publications and holds multiple patents related to stem cell technologies and somatic cell reprogramming. Dr. Liu’s innovative research bridges cellular manipulation and translational medicine, making significant strides in disease modeling and regenerative therapies.
Main research directions include: 1) Molecular mechanisms of stem cell pluripotency maintenance and fate regulation; 2) Establishment of disease models in animals using pluripotent stem cells; 3) Molecular, cellular, and developmental foundations of allogeneic chimerism; 4) Multi-dimensional data analysis and mathematical modeling of cell fate transformation.
Key research areas include:
1. Cellular fate manipulation techniques and mechanisms, including induced pluripotent stem cells (iPSCs) and pluripotent stem cell ground state transitions (PNT)
2. In vitro induction of germ cells and reproductive development
3. Animal modeling of human diseases
4. Molecular and cellular developmental foundations of mammalian allogeneic chimerism
5. Mathematical modeling of cellular fate regulation
• Guangzhou High-Level Talent "Outstanding Expert" (2022)
• National Natural Science Foundation of China Outstanding Young Scientist (2020)
• Chief Scientist, National Key Research and Development Plan (2019)
• China Emerging Technology Scientist (2018)
• Outstanding Achievement Award in Science and Technology, Chinese Academy of Sciences (2017, Major Contributor)
• Outstanding Young Scientist and Technologist, Guangzhou Branch, Chinese Academy of Sciences (2016)
• Guangdong Province Special Support Plan for Young Top Talents in Science and Technology Innovation (2016)
• First Prize, Guangdong Province Science and Technology (2015)
• First Prize, Guangzhou Science and Technology (2015)
• Guangzhou Pearl River Science and Technology New Star (2014)
1. Liu Y#, Zhang S#, Zou G, An J, Li Y, Lin D, Wang D, Li Y, Chen J, Feng T, Li H, Chen Y, Zhang M, Kumar M, Wang L*, Hou R*, Liu J* (2024). Generation and characterization of giant panda induced pluripotent stem cells. Sci Adv. 10(38):eadn7724. doi: 10.1126/sciadv.adn7724. Epub 2024 Sep 20.
2. Li, C., X. Xu, S. Chen, A. Xu, T. Guan, H. Wu*, D. Pei* and J. Liu* (2024). Epigenetic reshaping through damage: promoting cell fate transition by BrdU and IdU incorporation. Cell Biosci, 14(1): 9.
3. Wu, H., Li, C., Masood, M., Zhang, Z., Ester, G., Alvaro, C., Zou, G., Xu, X., Wang, L., Zhao, G., Yu, S., Zhu, P.,Wang, B., Qin, D., and J. Liu* (2022). Static Magnetic Fields Regulate T-Type Calcium Ion Channels and Mediate Mesenchymal Stem Cells Proliferation. cells, 11(15):2460.
4. Lin, R. #, Z. Zhai#, J. Kuang#, C. Wu, Y. Yao, R. Shi, J. He, S. Xu, P. Li, Y. Fan, W. Li, Z. Wu, X. Li, J. Ming, J. Guo, B. Wang, D. Li, S. Cao, X. Zhang, Y. Li, D. Pei* & J. Liu* (2022) H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition. Cell Biosci, 12, 89.
5. Yu, S. #, C. Zhou#, J. He#, Z. Yao, X. Huang, B. Rong, H. Zhu, S. Wang, S. Chen, X. Wang, B. Cai, G. Zhao, Y. Chen, L. Xiao, H. Liu, Y. Qin, J. Guo, H. Wu, Z. Zhang, M. Zhang, X. Zhao, F. Lan, Y. Wang, J. Chen, S. Cao*, D. Pei* & J. Liu* (2022) BMP4 drives primed to naive transition through PGC-like state. Nat Commun, 13, 2756.
6. Kuang, J. #, Z. Zhai#, P. Li, R. Shi, W. Guo, Y. Yao, J. Guo, G. Zhao, J. He, S. Xu, C. Wu, S. Yu, C. Zhou, L. Wu, Y. Qin, B. Cai, W. Li, Z. Wu, X. Li, S. Chu, T. Yang, B. Wang, S. Cao, D. Li, X. Zhang, J. Chen, J. Liu*& D. Pei* (2021) SS18 regulates pluripotent-somatic transition through phase separation. Nat Commun, 12, 4090.
7. Fu, M. #, H. Chen#, Z. Cai, Y. Yang, Z. Feng, M. Zeng, L. Chen, Y. Qin, B. Cai, P. Zhu, C. Zhou, S. Yu, J. Guo, J. Liu*, S. Cao* & D. Pei* (2021) Forkhead box family transcription factors as versatile regulators for cellular reprogramming to pluripotency. Cell Regen, 2；10(1):17
8. Liu, Y., J. He, R. Chen, H. Liu, J. Chen, Y. Liu, B. Wang, L. Guo, D. Pei, J. Wang, J. Liu *& J. Chen* (2021) AP-1 activity is a major barrier of human somatic cell reprogramming. Cell Mol Life Sci. 78(15):5847-5863.
9. Yu, S. #, C. Zhou#, S. Cao#, J. He, B. Cai, K. Wu, Y. Qin, X. Huang, L. Xiao, J. Ye, S. Xu, W. Xie, J. Kuang, S. Chu, J. Guo, H. Liu, W. Pang, L. Guo, M. Zeng, X. Wang, R. Luo, C. Li, G. Zhao, B. Wang, L. Wu, J. Chen, J. Liu* & D. Pei * (2020) BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling. Nat Cell Biol, 22, 651-662.
10. Wu, L., G. Zhao, S. Xu, J. Kuang, J. Min, G. Wu, T. Wang, B. Wang, P. Zhu, D. Pei* & J. Liu* (2020) The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure. J Biol Chem. 296:100022.
11. Wang, B. #, L. Wu#, D. Li#, Y. Liu, J. Guo, C. Li, Y. Yao, Y. Wang, G. Zhao, X. Wang, M. Fu, H. Liu, S. Cao, C. Wu, S. Yu, C. Zhou, Y. Qin, J. Kuang, J. Ming, S. Chu, X. Yang, P. Zhu, G. Pan, J. Chen, J. Liu* & D. Pei* (2019) Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4. Cell Rep, 27, 3473-3485 e5.
12. Cao, S. #, S. Yu#, D. Li#, J. Ye, X. Yang, C. Li, X. Wang, Y. Mai, Y. Qin, J. Wu, J. He, C. Zhou, H. Liu, B. Zhao, X. Shu, C. Wu, R. Chen, W. Chan, G. Pan, J. Chen, J. Liu* & D. Pei* (2018) Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency. Cell Stem Cell, 22, 529-542 e5.
13. Cao, S. #, S. Yu, Y. Chen, X. Wang, C. Zhou, Y. Liu, J. Kuang, H. Liu, D. Li, J. Ye, Y. Qin, S. Chu, L. Wu, L. Guo, Y. Li, X. Shu, J. Chen, J. Liu* & D. Pei * (2017) Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage. J Biol Chem, 292, 19122-19132.
14. Li, D. #, J. Liu#, X. Yang#, C. Zhou, J. Guo, C. Wu, Y. Qin, L. Guo, J. He, S. Yu, H. Liu, X. Wang, F. Wu, J. Kuang, A. P. Hutchins*, J. Chen* & D. Pei* (2017) Chromatin Accessibility Dynamics during iPSC Reprogramming. Cell Stem Cell, 21, 819-833 e6.
15. Liu, J., Q. Han, T. Peng, M. Peng, B. Wei, D. Li, X. Wang, S. Yu, J. Yang, S. Cao, K. Huang, A. P. Hutchins, H. Liu, J. Kuang, Z. Zhou, J. Chen, H. Wu, L. Guo, Y. Chen, Y. Chen, X. Li, H. Wu, B. Liao, W. He, H. Song, H. Yao, G. Pan, J. Chen* & D. Pei* (2015) The oncogene c-Jun impedes somatic cell reprogramming. Nat Cell Biol, 17, 856-67.
16. Ouyang, J. #, W. Yu#, J. Liu#, N. Zhang, L. Florens, J. Chen, H. Liu, M. Washburn, D. Pei *& T. Xie* (2015) Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state. J Biol Chem, 290, 22782-94.
17. Chen, J. #, J. Liu#, Y. Chen, J. Yang, J. Chen, H. Liu, X. Zhao, K. Mo, H. Song, L. Guo, S. Chu, D. Wang, K. Ding & D. Pei* (2011a) Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. Cell Res, 21, 884-94.
18. Chen, J. #, J. Liu#, Q. Han, D. Qin, J. Xu, Y. Chen, J. Yang, H. Song, D. Yang, M. Peng, W. He, R. Li, H. Wang, Y. Gan, K. Ding, L. Zeng, L. Lai, M. A. Esteban & D. Pei* (2010) Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells. J Biol Chem, 285, 31066-72.
19. Chen, J#., J. Liu#, J. Yang, Y. Chen, J. Chen, S. Ni, H. Song, L. Zeng, K. Ding & D. Pei* (2011b) BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Res, 21, 205-12.