GIBH has extracted two compounds showing potent anti-EV71 activity

Enterovirus 71 (EV71) infections frequently manifest as hand, foot, and mouth disease (FHMD), as well as encephalitis in infants and young children. EV71 can even cause severe central nervous system disease, complications, and fatalities. At present, there is no specific treatment available for EV71. Recently, a study identified chrysosplenetin and penduletin, two o-methylated flavonols isolated from the leaves of Laggera pterodonta, have potent anti-EV71 activity. The results were published in Euroopean Journal of Pharmaceutical Sciences.

In this study conducted by Professor Tao Peng at Guangzhou Institutes of Biomedicine and Health, and Professor Xiaodong Luo at State Key Laboratory of Phytochemistry and Plant Resources in West China, Chrysosplenetin and Penduletin showed inhibition activity against EV71 viral RNA replication. Further analysis indicated that both chrysosplenetin and penduletin could effectively inhibit the infection of EV71 as well as other human enterovirus in cell culture. Thus, chemicals with similar structures could be pursued as candidates for the treatment of these viral infections. This study was supported by National Basic Research Program (973).