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2013.11 – now |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Principal Investigator |
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2011.07 – 2011.10 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Associate Principal Investigator |
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2006.09 – 2011.06 |
Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Ph.D |
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2002.09 – 2006.06 |
Sun Yat-sen University/Bachelor |
1. To study the molecular regulation mechanism of cell fate determination based on somatic cell reprogramming and to develop a technology system focusing on the application of induced pluripotent stem cells (iPSCs).
2. To excavate the important biological mechanism by bioinformatics based on the data of epigenetic group and single-cell transcriptome collected in the cell fate transformation model.
Patents
1. Chinese Invention Patent, A method for preparing a premature aging animal model, CN202410622973.2, 2024-05-17, Jiekai Chen, Haoyu Wu, Xiongzhi Quan, Jiaoyang Sun.
2. Chinese Invention Patent, A method for preparing a brain organoid model with neural crest cell group and its application, CN202311873376.9, 2023-12-29, Jiekai Chen, Jie Wang, Ziyun Shan, Xiuyu Chen, Yingying Zhao, Yujian Liu.
3. PCT, Combination of m6A RNA methylase inhibitor and immune checkpoint inhibitor for treating tumors, PCT/CN2023/092911, 2023-05-09, Jiekai Chen, Xiangqian Kong, Kaixin Wu, Hongling Wu, Tongke Tang.
4. European Patent, Method for preparing induced pluripotent stem cell, composition used in method, and uses thereof, EP3070163B1, 2021-01-06, Duanqing Pei, Jing Liu, Jiekai Chen, Meixiu Peng.
5. European Patent, New serum-free medium for inducing pluripotent stem cells quickly with high efficiency and method using thereof, EP2423302B8, 2015-07-08, Duanqing Pei, Jiekai Chen, Jing Liu.
6. Chinese Invention Patent, New serum-free medium for inducing pluripotent stem cells quickly with high efficiency and method using thereof, ZL200910038883.4, 2012-02-29, Duanqing Pei, Jiekai Chen, Jing Liu.
1. Second Prize of National Natural Science Award（2018）
2. Guangdong Special Support Plan Leading Talent（2018）
3. First Prize of Guangdong Provincial Science and Technology Award（2015）
4. Guangdong Provincial Youth Science and Technology Innovation Award（2022）
5. First Prize of Guangzhou Science and Technology Award（2015）
6. 25th Guangdong Provincial Youth May Fourth Medal（2023）
7. Youth May Fourth Medal of CAS（2022）
8. Outstanding Science and Technology Achievement Award of CAS（2017）
9. Nan Yue Innovation Award（2016）
10. Outstanding Young Scientist of CAS（2014）
11. Outstanding Postgraduate Tutor of CAS（2022、2021、2020）
1. Jiadong Liu#; Mingwei Gao#; Jiangping He#; ...; Jiekai Chen*. The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity, Nature, 2021, 591(7849): 322-326.
2. Shan Ziyun#; Zhao Yingying#; Chen Xiuyu#, Zhan Guodong#, ..., Zou Xiaobing*, Wang Jie*, Chen Jiekai*. KMT2D deficiency leads to cellular developmental disorders and enhancer dysregulation in neural-crest-containing brain organoids. Science Bulletin. 2024 Sep 7:S2095-9273(24)00638-8. doi: 10.1016/j.scib.2024.09.004.
3. Shangtao Cao*#; Huijian Feng#; Hongyan Yi#; Mengjie Pan#; Lihui Lin#; ...; Duanqing Pei*; Jiekai Chen* and Yanlin Ma*. Single-cell RNA sequencing reveals the developmental program underlying proximal–distal patterning of the human lung at the embryonic stage. Cell Research, 2023 Apr 21. doi: 10.1038/s41422-023-00802-6.
4. Lingmei JIn;...; Jiekai Chen*, Ling Qi* and Kaixin Wu*. Transposable elements activation triggers necroptosis in mouse embryonic stem cells. Cell Death Dis. 2023 Mar 7;14(3):184.
5. Wu Fang; ...; Chen Jiekai*; He Jiangping*. Species-specific rewiring of definitive endoderm developmental gene activation via endogenous retroviruses through TET1-mediated demethylation, Cell reports, 2022,41(11):111791.
6. Huijian Feng; Lihui Lin*; Jiekai Chen*. scDIOR: single cell RNA-seq data IO software, BMC Bioinformatics, 2022, 23(1): 16.
7. Yuting Liu; ...; Jing Liu*; Jiekai Chen*. AP-1 activity is a major barrier of human somatic cell reprogramming, Cellular and Molecular Life Sciences, 2021, 78(15): 5847-5863.
8. Jiangping He; ...; Andrew P. Hutchins*; Jiekai Chen*. Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE, Nature Communications, 2021, 12(1): 1456.
9. Feng-Liang Liu#; Kaixin Wu#; Jiaoyang Sun#; Zilei Duan#; ...; Guangming Wu*; Yong-Tang Zheng*; Jiekai Chen*. Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, National Science Review, 2021, Vol. 8, nwaa285 .
10. Jiadong Liu#; Mingwei Gao#; ...; Jiekai Chen*. YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways, Cell Reports, 2020, 32(10): 108120.
11. Jiekai Chen*. Perspectives on somatic reprogramming: spotlighting epigenetic regulation and cellular heterogeneity, Current Opinion in Genetics & Development, 2020, 64: 21-25.
12. Jiangping He#; Shuijiang Cai#; Huijian Feng#; Baomei Cai#; Lihui Lin#; ....; Xinwen Chen*; Xilong Deng*; Jiekai Chen*. Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients, Protein & Cell, 2020, 11(9): 680-687.
13. Kaixin Wu#; He Liu#; ...; Jiekai Chen*. SETDB1-Mediated Cell Fate Transition between 2C- Like and Pluripotent States, Cell Reports, 2020, 30(1): 25-36.
14. Lin Guo#; Lihui Lin#; Xiaoshan Wang#; ...; Duanqing Pei*; Jiekai Chen*. Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq, Molecular Cell, 2019, 73(4): 815-829.
15. Zhiwei Zhou.;...; Duanqing Pei.*; Jiekai Chen.*. Kdm2b regulates somatic reprogramming through variant PRC1 complex dependent function. Cell Reports, 21(8), 2160-70.
16. Dongwei Li.#; Jing Liu.#; Xuejie Yang.#; ...; Hutchins, AP.*; Jiekai Chen.*; Duanqing Pei.*. Chromatin Accessibility Dynamics During Reprogramming. Cell Stem Cell, 2017 Dec 7;21(6):819-833.e6.
17. Jing Liu.; ...; Jiekai Chen.*; Duanqing Pei.*. The oncogene c-Jun impedes somatic cell reprogramming. Nature Cell Biology 17 (7), 856-67.
18. Jiekai Chen#; He Liu#;...Duanqing Pei*. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. Nature Genetics 45(1), 34-42.
19. Jiekai Chen#; Lin Guo#;...; Duanqing Pei*. Vitamin C modulates Tet1 function during somatic cell reprogramming. Nature Genetics. 45(12), 1504-9.
20. Jiekai chen#; Jing Liu;# ...; Duanqing Pei*. Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. Cell Research 21, 884-894.
21. Jiekai chen#; Jing Liu;# ...; Duanqing Pei*. BMPs functionally replace Klf4 and support efficient reprogramming of mouse fibroblasts by Oct4 alone. Cell Research 21, 205-212.
22. Jiekai chen#; Jing Liu#; Qingkai Han# ...; Duanqing Pei*. Towards an Optimized Culture Medium for the Generation of Mouse Induced Pluripotent Stem Cells. Journal of Biological Chemistry 285, 31066-31072.
23. Yang Wang#; Jiekai Chen#; ...; Duanqing Pei*; Guoliang Xu*. Reprogramming of mouse and human somatic cells by high-performance engineered factors. EMBO reports 12, 373-378.
24. Jiekai Chen; Qingkai Han; and Duanqing Pei. EMT and MET as paradigms for cell fate switching. J Mol Cell Biol.
25. Jiekai Chen; and Duanqing Pei. Reprogramming in suspension. Nature Methods 9, 449-451.
26. Yulin Chen#; Lin Guo#; Jiekai Chen#;...; .Duanqing Pei*; Feng Zhang*. Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripotent factors on genome integrity. BMC Genomics. 15:79.