People

WANG Kepin

Title：Principle Investigator

Subject：

Email：wang_kepin@gibh.ac.cn

Address：Kaiyuan Dadao 190,510530,Guangzhou,China

Study/Work Experience

2022 - now	Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, China/Research fellow
2018 - 2022	Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, China/Associate research fellow
2016 - 2018	Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, China/Assistant research fellow
2011 - 2016	University of Chinese Academy of Sciences, China/Ph.D.
2007 - 2011	Anhui University, China/B.E.

Research Areas

Construction and application of gene modified large animal models; Development and optimization of novel gene editing technology.

Academic Performance

Representative Papers

(1) Jingke Xie, Zhenpeng Zhuang, Shixue Gou, Quanjun Zhang, Xia Wang, Ting Lan, Meng Lian, Nan Li, Yanhui Liang, Zhen Ouyang, Yinghua Ye, Han Wu, Liangxue Lai, Kepin Wang, Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription, Nucleic Acids Research, 2023.

(2) Qin Jin, Xiaoyi Liu, Zhenpeng Zhuang, Jiayuan Huang, Shixue Gou, Hui Shi, Yu Zhao, Zhen Ouyang, Zhaoming Liu, Lei Li, Junjie Mao, Weikai Ge, Fangbing Chen, Manya Yu, Yezhi Guan, Yinghua Ye, Chengcheng Tang, Ren Huang, Kepin Wang, Liangxue Lai, Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation, Genome Biology, 2023, 24:8.

(3) Yanhui Liang, Jingke Xie, Quanjun Zhang, Xiaomin Wang, Shixue Gou, Lihui Lin, Tao Chen, Weikai Ge, Zhenpeng Zhuang, Meng Lian, Fangbing Chen, Nan Li, Zhen Ouyang, Chengdan Lai, Xiaoyi Liu, Lei Li, Yinghua Ye, Han Wu, Kepin Wang, Liangxue Lai, AGBE: A dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns, Nucleic Acids Research, 2022, 50(9):5384-5399.

(4) Jingke Xie, Weikai Ge, Nan Li, Qishuai Liu, Fangbing Chen, Xiaoyu Yang, Xingyun Huang, Zhen Ouyang, Quanjun Zhang, Yu Zhao, Zhaoming Liu, Shixue Gou, Han Wu, Chengdan Lai, Nana Fan, Qin Jin, Hui Shi, Yanhui Liang, Ting Lan, Longquan Quan, Xiaoping Li, Kepin Wang, Liangxue Lai, Efficient base editing for multiple genes/loci in pigs using base editors, Nature Communications, 2019, 10:2852.

(5) Kepin Wang, Qin Jin, Degong Ruan, Yi Yang, Qishuai Liu, Han Wu, Zhiwei Zhou, Zhen Ouyang, Zhaoming Liu, Yu Zhao, Bentian Zhao, Quanjun Zhang, Jiangyun Peng, Chengdan Lai, Nana Fan, Yanhui Liang, Ting Lan, Nan Li, Xiaoshan Wang, Xinlu Wang, Yong Fan, Pieter A. Doevendans, Joost P.G. Sluijter, Pentao Liu, Xiaoping Li, Liangxue Lai, Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing, Genome Research, 2017, 27(12): 2061-2071.