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2012.05 – now |
Guanzhou Institutes of Biosciences and Heath, Chinese Academy of Sciences/ Principal Investigator |
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2011.05 – 2012.05 |
SMT Inc./Chief Technology Officer and Vice President |
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2010.05 – 2011.05 |
Medical University of South Carolina/Associate Professor |
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2001.03 – 2010.05 |
Duke University Medical Center/Assistant Professor (Tenure Track) |
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1993.03 – 2001.03 |
Medical College of Georgia/postdoctoral fellow |
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1992.09 – 1993.03 |
Vanderbilt University Medical Center/ postdoctoral fellow |
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1991.11 – 1992.09 |
Chinese Academy of Medicines Sciences/ Assistant Professor |
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1987.09 – 1991.11 |
Peking Union Medical College/Ph.D |
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1985.09 – 1987.09 |
Chinese Academy of Medicines Sciences/Research assistant |
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1980.09 – 1985.08 |
Hunan Medical College/Bachelor |
International distinguished expert recruited by Chinese Government “Thousand Talents Program” in 2014. His research group is interested of drug discovery, stem cell research and disease biomarker screening, particularly interested in chronic liver disease and metabolic syndrome, currently is the Chief Scientist for stem cell mediated repairing cirrhosis research of 973 program. His inventions were granted several international patents covering these fields of DNA protection from mutation, tissue regeneration, gene silence and single cell RNA amplification. One product driven from Dr. Li’s dsRNA Patent that enter and finished clinical trial phase I b, first-in-human safety and tolerability study of an RNAi-based therapy, NUC B1000, among patients with mild to moderate chronic HBV.
1. COMPOSITION AND APPLICATION THEREOF (ZL201910091150.0)
2. CULTURE MEDIUM FOR EXPANDING AND CULTURING HUMAN LIVER PROGENITOR CELLS AND APPLICATION THEREOF (ZL201910073515.7)
3. CULTURE MEDIUM FOR SCREENING AND EXPANDING LIVER STEM CELLS AND USE THEREOF (201910098063.8)
4. USE OF SERUM AMYLOID A INHIBITOR IN PREPARATION OF DRUG FOR TREATING ACUTE LIVER INJURY, ACUTE LIVER FAILURE OR ACUTE-ON-CHRONIC LIVER FAILURE (202010772541.1)
5. HUMAN GLUCAGON-LIKE PEPTIDE-1 RECEPTOR ACTIVATOR AND APPLICATION THEREOF (202011411830.5)
6. MARKER FOR VIRAL PNEUMONIA AND APPLICATION THEREOF (202010157603.8)
7. Nucleic Acid Filter for Tumorigenic Factors. (6,117,846)
2023 Most Outstanding Science and Technology Worker
2014 National Distinguished Specialist in Biomedicine, “Thousand Talent Global Experts” Recruitment Program of the Chinese Central Government
2011 Macao China Anti-Cancer Charity Association, Honorary President
2008 NIH Invited Keynote Speaker
2006 Duke Stanback Award for environmental factors, stem cell and tumorgenesis research
2004 ChunHui Program Scholar awarded by Ministry of Education People’s Republic of China
1999 Designated as an “Alien with Extraordinary Ability in Science and Education” by the US Immigration and Naturalization Service
1996 National Excellence Educational Publishing Prize issued by: National Education Ministry, National News and Publication Agency, People’s Republic of China
1. Sammad A, Ahmed T, Ullah K, Hu L, Luo H, Alphayo Kambey P, Faisal S, Zhu H, Li Y, Wang Y. Vitamin C Alleviates the Negative Effects of Heat Stress on Reproductive Processes by Regulating Amino Acid Metabolism in Granulosa Cells. Antioxidants (Basel). 2024 May 27;13(6):653.
2. Abbas N, You K, Getachew A, Wu F, Hussain M, Huang X, Chen Y, Pan T, Li Y. Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site. Stem Cell Res Ther. 2024 Feb 20;15(1):48. doi: 10.1186/s13287-024-03656-w. PMID: 38378583; PMCID: PMC10877762.
3. Yu X, Tao J, Wu Y, Chen Y, Li P, Yang F, Tang M, Sammad A, Tao Y, Xu Y, Li YX. Deficiency of ASGR1 Alleviates Diet-Induced Systemic Insulin Resistance via Improved Hepatic Insulin Sensitivity. Diabetes Metab J. 2024 Feb 2. doi: 10.4093/dmj.2023.0124. Epub ahead of print. PMID: 38310881.
4. Yang Z, Huang X, Zhang J, You K, Xiong Y, Fang J, Getachew A, Cheng Z, Yu X, Wang Y, Wu F, Wang N, Feng S, Lin X, Yang F, Chen Y, Wei H, Li YX. Hepatic DKK1-driven steatosis is CD36 dependent. Life Sci Alliance. 2022 Nov 21;6(1):e202201665.
5. You K, Wang Y, Chen X, Yang Z, Chen Y, Tan S, Tao J, Getachew A, Pan T, Xu Y, Zhuang Y, Yang F, Lin X, Li Y. Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury. Biochem Biophys Res Commun. 2022 Nov 28;639:20-28.
6. Cheng Z, Guo D, Ruzi A, Pan T, You K, Chen Y, Huang X, Zhang J, Yang F, Niu L, Xu K, Li YX. Modeling MEN1 with Patient-Origin iPSCs Reveals GLP-1R Mediated Hypersecretion of Insulin. Cells. 2022 Aug 3;11(15):2387.
7. Tao J, Chen Y, Zhuang Y, Wei R, Getachew A, Pan T, Yang F, Li Y. Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle. Curr Issues Mol Biol. 2022 Jan 18;44(2):470-482.
8. Pan T, Wang N, Zhang J, Yang F, Chen Y, Zhuang Y, Xu Y, Fang J, You K, Lin X, Li Y, Li S, Liang K, Li YX, Gao Y. Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy. Stem Cell Res Ther. 2022 Apr 11;13(1):159. doi: 10.1186/s13287-022-02831-1. PMID: 35410439; PMCID: PMC8996222.
9. Li P, Liu Y, Cheng Z, Yu X, Li Y. COVID-19-associated liver injury: Clinical characteristics, pathophysiological mechanisms and treatment management. Biomed Pharmacother. 2022 Oct;154:113568.
10. Getachew A, Hussain M, Huang X, Li Y. Toll-like receptor 2 signaling in liver pathophysiology. Life Sci. 2021 Nov 1;284:119941.
11. Getachew A, Abbas N, You K, Yang Z, Hussain M, Huang X, Cheng Z, Tan S, Tao J, Yu X, Chen Y, Yang F, Pan T, Xu Y, Xu G, Zhuang Y, Wu F, Li Y. SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury. iScience. 2021 Apr 29;24(5):102483.
12. Pan T, Tao J, Chen Y, Zhang J, Getachew A, Zhuang Y, Wang N, Xu Y, Tan S, Fang J, Yang F, Lin X, You K, Gao Y, Li YX. Robust expansion and functional maturation of human hepatoblasts by chemical strategy. Stem Cell Res Ther. 2021 Feb 25;12(1):151.
13. Yuan F, Wang N, Chen Y, Huang X, Yang Z, Xu Y, You K, Zhang J, Wang G, Zhuang Y, Pan T, Xiong Y, Yu X, Yang F, Li Y. Calcitriol promotes the maturation of hepatocyte-like cells derived from human pluripotent stem cells. J Steroid Biochem Mol Biol. 2021 Jul;211:105881.
14. Yuan F, Xu Y, You K, Zhang J, Yang F, Li YX. Calcitriol alleviates ethanol-induced hepatotoxicity via AMPK/mTOR-mediated autophagy. Arch Biochem Biophys. 2021 Jan 15;697:108694.
15. Xiong Y, Chen Y, Huang X, Yang Z, Zhang J, Yu X, Fang J, Tao J, You K, Cheng Z, Tan S, Xu Y, Yuan F, Liu Y, Zhuang Y, Yang F, Li Y. Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity. Life Sci. 2021 Mar 1;268:119000.
16. Yang Z, Yuan F, Wang N, Liu Y, Zhang J, Wei R, Wu F, Wu Y, You K, Chen Y, Yang F, Li YX. Generation of a DKK1 homozygous knockout human embryonic stem cell line WAe001-A-21 using CRISPR/Cas9. Stem Cell Res. 2021 Mar;51:102161.
17. Xu Y, Tao J, Yu X, Wu Y, Chen Y, You K, Zhang J, Getachew A, Pan T, Zhuang Y, Yuan F, Yang F, Lin X, Li YX. Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression. JCI Insight. 2021 Oct 8;6(19):e147038.
18. Getachew A, Yang Z, Huang X, Wu F, Liu YY, Yan C, Yang F, Li Y. Generation of a TLR2 homozygous knockout human embryonic stem cell line WAe001-A-64 using CRISPR/Cas9 editing. Stem Cell Res. 2021 Jul;54:102401.
19. Wu F, Chen Y, You K, Tan S, Xu Y, Wang PH, Liu S, Li YX. Generation of WAe001-A-58 human embryonic stem cell line with inducible expression of the SARS-CoV-2 nucleocapsid protein. Stem Cell Res. 2021 May;53:102197. doi: 10.1016/j.scr.2021.102197. Epub 2021 Jan 26. PMID: 33771478; PMCID: PMC7835078.
20. Wei-Xin Hong , Yan Chen, Kai You , Sheng-Lin Tan, Fei-Ma Wu, Jia-Wang Tao, Xu-Dan Chen, Jia-Ye Zhang, Yue Xiong, Fang Yuan, Zhen Yang, Ting-Ting Chen, Xin-Wen Chen, Ping Peng, Qiang Tai, Jian Wang, Fu-Chun Zhang and Yin-Xiong Li. Celebrex Adjuvant Therapy on Coronavirus Disease 2019: An Experimental Study. Frontiers in Pharmacology, 2020 Nov 06, 11(561674). IF:4.22
21. Xu Y, Wu Y, Xiong Y, Tao J, Pan T, Tan S, Gao G, Chen Y, Abbas N, Getachew A, Zhuang Y, You K, Yang F, Li YX. Ascorbate protects liver from metabolic disorder through inhibition of lipogenesis and suppressor of cytokine signaling 3 (SOCS3). Nutr Metab (Lond). 2020 Mar 4;17:17. doi: 10.1186/s12986-020-0431-y. PMID: 32158492; PMCID: PMC7057613.
22. Liu Y, Zhang J, Chen Y, Sohel H, Ke X, Chen J, Li YX. The correlation and role analysis of COL4A1 and COL4A2 in hepatocarcinogenesis. Aging (Albany NY). 2020 Jan 5;12(1):204-223. doi: 10.18632/aging.102610. Epub 2020 Jan 5. PMID: 31905170; PMCID: PMC6977693.
23. Liu J, Pan T, Chen Y, Liu Y, Yang F, Chen Q, Abbas N, Zhong M, Zhang Q, Xu Y, Li YX. Repair of acute liver damage with immune evasive hESC derived hepato-blasts. Stem Cell Res. 2020 Dec;49:102010. doi: 10.1016/j.scr.2020.102010. Epub 2020 Sep 26. PMID: 33011360.
24. Abbas N, Getachew A, You K, Shah Z, Chen Y, Tao J, Hussain M, Yang F, Zhuang Y, Xu Y, Li YX. Kupffer cells mediate the recruitment of hepatic stellate cells into the localized liver damage. Biochem Biophys Res Commun. 2020 Aug 20;529(2):474-479. doi: 10.1016/j.bbrc.2020.06.041. Epub 2020 Jul 2. PMID: 32703454.
25. Pan T, Chen Y, Zhuang Y, Yang F, Xu Y, Tao J, You K, Wang N, Wu Y, Lin X, Wu F, Liu Y, Li Y, Wang G, Li YX. Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts. Stem Cell Res Ther. 2019 Dec 2;10(1):364. doi: 10.1186/s13287-019-1463-y. PMID: 31791391; PMCID: PMC6888929. IF:8.393
26. Xu G, Wu F, Gu X, Zhang J, You K, Chen Y, Getachew A, Zhuang Y, Zhong X, Lin Z, Guo D, Yang F, Pan T, Wei H, Li YX. Direct Conversion of Human Urine Cells to Neurons by Small Molecules. Sci Rep. 2019 Nov 13;9(1):16707. doi: 10.1038/s41598-019-53007-6. PMID: 31723223; PMCID: PMC6854089.
27. Liu Y, Wu F, Liu D, Wei R, Abbas N, Xia J, Li D, Wang H, Zhuang Y, Guo D, Chen Y, Wu Y, Ke X, Tao J, Yang F, Lai K, Shu X, Li YX. Generation of WAe001-A-15, a human embryonic stem cell line with miR-122 doxycycline-inducible expression. Stem Cell Res. 2018 May;29:84-87. doi: 10.1016/j.scr.2018.03.007. Epub 2018 Mar 23. PMID: 29627726.
28. Yuan F, Guo D, Liu Y, Xu Y, Gao G, Wu Y, Yang F, Ke X, Lai K, Wei H, Li YX. Generation of an ASS1 heterozygous knockout human embryonic stem cell line, WAe001-A-13, using CRISPR/Cas9. Stem Cell Res. 2018 Jan;26:67-71. doi: 10.1016/j.scr.2017.11.007. Epub 2017 Nov 10. PMID: 29247816.
29. Wei R, Yuan F, Wu Y, Liu Y, You K, Yang Z, Chen Y, Getachew A, Wang N, Xu Y, Zhuang Y, Yang F, Li YX. Construction of a GLI3 compound heterozygous knockout human embryonic stem cell line WAe001-A-20 by CRISPR/Cas9 editing. Stem Cell Res. 2018 Oct;32:139-144. doi: 10.1016/j.scr.2018.09.010. Epub 2018 Sep 17. PMID: 30278376.
30. Wilkbanks AM, Fralish GB, Kirby ML, Barak LS, Li Y-X* and Caron MG.* Arrestin 2 regulates zebrafish development through the sonic hedgehog pathway. Science. 306:2264-2267, 2004. (*co-correspondence authors). PMID: 15618520