People
BAO Xichen
Title:Principle Investigator
Subject:
Email:liu_xingguo@gibh.ac.cn
Address:Kaiyuan Dadao 190,510530,Guangzhou,China
Study/Work Experience

2018 – now

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Investigator

2015 – 2017

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Associate Investigator

2011 – 2014

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Research Assistant

2006 – 2011

University of Science and Technology of China, Hefei, China, Ph.D. in Biochemistry

2002 – 2006

Anhui University, Hefei, China, Bachelor

Research Areas

RNA-protein interaction during cell fate transition

Patents

1. Bao Xichen, Zhao Wenxue, Xiong Zhi, Yin Chao, Zhang Yuqi, Pan Weiqi; Lin Yingying, Wang Xiwei, He Jun; 用于抑制SARS-Cov-2的组合物及载体系统. Chinese patent, ZL 2021 1 0448000.8

2. Pei Duanqing, Migule Esteban, Bao Xichen, Liao Baojian, Zhang Biliang, 一种将微小核糖核酸簇用于改变细胞命运的方法. Chinese patent, ZL 2011 1 0067834.0

3. Zhang Biliang, Migule Esteban, Bao Xichen, Guo Hengpeng, Yin Menghui, Wang Xiwei, 一种捕获核酸结合蛋白的方法和试剂盒, Chinese patent, 201710080808.9


Academic Performance

1. 2019:Nature Science award, Guangdong Province, FRIST PRIZE

2. 2018:Outstanding youth of Guangdong Province

3. 2019:Excllent member of Youth Innovation Promotion Association, CAS

4. 2016:Guangzhou Pearl River Science and Technology New Star

5. 2015:Nature Science award, Guangdong Province, FRIST PRIZE

6. 2015:Scientific and Technological Advancement award, Guangzhou City


Representative Papers

1.  Bao X,* Xiaoxing Li,* William K. K. Wu* Yanquan Zhang* and Liang Zhou,*Editorial: Protein-RNA interplay-regulated signaling in stem cells and cancerFront Cell Dev Biol.2023 Oct 16:11:1304817. doi: 10.3389/fcell.2023.1304817. eCollection 2023.

2.  Ruiqi Zhao#; Xin Fang#; Zhibiao Mai#; Xi Chen; Jing Mo; Yingying Lin; Rui Xiao; Bao X*; Xiaocheng Weng*; Xiang Zhou*; Transcriptome-wide identification of single-stranded RNA binding proteins, CHEMICAL SCIENCE, 2023, 14(15): 4038-4047.

3.  Zheng M, Lin Y, Wang W, Zhao Y, Bao X*. Application of nucleoside or nucleotide analogues in RNA dynamics and RNA-binding protein analysis. Wiley Interdiscip Rev RNA. 2022 Feb 25:e1722. doi: 10.1002/wrna.1722. Epub ahead of print. PMID: 35218164.

4.  Guo X#, Tariq M#, Lai Y#, Kanwal S#, Lv Y#, Wang X#, Li N, Jiang M, Meng J, Hu J, Yuan J, Luo Z, Ward C, Volpe G, Wang D, Yin M, Qin B, Zhang B*, Bao X*, Esteban MA*. Capture of the newly transcribed RNA interactome using click chemistry. Nat Protoc. 2021 Oct 25.  

5.  Lv Y#, Bu C#, Meng J, Ward C, Volpe G, Hu J, Jiang M, Guo L, Chen J, Esteban MA*, Bao X*, Cheng Z*. Global Profiling of the Lysine Crotonylome in Different Pluripotent States. Genomics Proteomics Bioinformatics. 2021 Feb;19(1):80-93. 

6.  Shahzina Kanwal , Xiangpeng Guo , Carl Ward, Giacomo Volpe, Baoming Qin , Miguel A. Esteban *, Bao X * Role of Long Non-coding RNAs in Reprogramming to Induced PluripotencyGenomics Proteomics Bioinformatics2020 1816-25

7.  Hou L*, Wei Y, Lin Y, Wang X, Lai Y, Yin M, Chen Y, Guo X, Wu S, Zhu Y, Yuan J, Tariq M, Li N, Sun H, Wang H, Zhang X, Chen J, Bao X*, Jauch R*. Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. Nucleic Acids Res. 2020 Feb 4:gkaa067.

8.  Bao X*#, Guo X#, Yin M#, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, LiN, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, ZhangC, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B*, Esteban MA*. Capturing the interactome of newly transcribed RNA. Nat Methods. 2018 Mar;15(3):213-220. 

9.  Bao X*#, Wu H#, Zhu X#, Guo X, Hutchins AP, Luo Z, Song H, Chen   Y, Lai K, Yin M, Xu L, Zhou L, Chen J, Wang D, Qin B, Frampton J, Tse HF, Pei D, Wang H, Zhang B, Esteban MA*. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Res. 2015 Jan; 25(1): 80-92. 

10. Bao X#, Zhu X, Liao B, Benda C, Zhuang Q, Pei D, Qin B, Esteban MA. MicroRNAs in somatic cell reprogramming. Curr Opin Cell Biol. 2013 Apr; 25(2): 208-14.

11. Liao B#Bao X#, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA, Pei D. MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem. 2011 May 13; 286(19): 17359-64.