Infection and Immunobiology

Our main research directions in Infection and Immunobiology are: developing novel anti-tumor immune cell therapies, including ITNK cells and CAR-T cells; developing novel humanized mouse models, such as tumor humanized mouse models with immune systems (Immune PDX) and liver humanized mouse models; the mechanisms of cross-species transmission of H5N1, H7N9, and H10N8 influenza viruses, the assembly mechanisms of influenza viruses, the invasion mechanisms of coronaviruses, and the stabilization of the surface antigen S protein of novel coronavirus; using structural biology and biochemistry methods to elucidate the pathogenic mechanisms of infectious microorganisms and developing intervention strategies based on an understanding of their pathogenic mechanisms. The infection and immunity mechanisms and pathogenic mechanisms of HIV, emerging and re-emerging infectious diseases, and exploring new strategies against pathogens. We have achieved fruitful results in building anti-TB drug screening, evaluation models and efficacy assessment, with some research at the world's leading level. In addition, we are involved in the research and development of TB therapeutic vaccines, and have achieved initial results.