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Aug 08, 2024MSC-Mediated Mitochondrial Transfer Restores Mitochondrial DNA and Function in Neural Progenitor Cells of Leber's Hereditary Optic NeuropathyThe results suggest that MSCs can transfer functional mitochondria to neural progenitor cells, thus restoring their function and potentially offering a new therapeutic strategy for mitochondrial diseases.Researchersled byProf. LIU Xingguo fromGuangzhou Institutes of Biomedicine and Healthof Chinese Academy of Sciences and Prof. ZHANG QingjiongfromZhongshan Ophthalmic Centerhave discovered that that MSC-mediated mitochondrial transfer can... -
Jul 30, 2024Mechanisms of Aging Associated Protein Translation Deficiency DiscoveredThe study discovered that METTL1/WDR4-mediated tRNA-m7G methylationwas essential in the preservation of proteostasis in healthy cells, which play an important role in the prevention of premature aging.The teams led by Prof. WANG Tao and Prof. WANG Jie from GIBH collaborated to identify novel mechanisms for regulating aging. The finding was published in Nature Communications with the title "Perturbation of METTL1-mediated tRNA N7-methy... -
Jul 11, 2024Researchers Develop a Fluorosulfate Containing Enrichable and Latent Bioreactive Unnatural Amino Acid for Protein Interaction ResearchProf. TANG Shibing from Guangzhou Institutes of Biomedicine and Health (GIBH), the Chinese Academy of Sciences, in collaboration with Prof. YANG Bing of Zhejiang University and associate Prof. LIU Chao of Beihang University, published an...Prof. TANG Shibing from Guangzhou Institutes of Biomedicine and Health (GIBH), the Chinese Academy of Sciences, in collaboration with Prof. YANG Bing of Zhejiang University and associate Prof. LIU Chao of Beihang University, published an... -
Jul 11, 2024GIBH Develope a New Tool CACIMAR for Analyzing Cross-Species Single-Cell Sequencing DataRecently, WANG Jie's research group from the Guangzhou Institutes of Biomedicine and Health (GIBH), the Chinese Academy of Sciences, developed a new computational tool named CACIMAR (Cross-species Analysis of Cell Identities, Markers, Re...Recently, WANG Jie's research group from the Guangzhou Institutes of Biomedicine and Health (GIBH), the Chinese Academy of Sciences, developed a new computational tool named CACIMAR (Cross-species Analysis of Cell Identities, Markers, Re... -
Jul 11, 2024Researchers Uncover Novel Mechanism Regulating GPCR-G Protein Signaling from EndosomesRecently, researchers from Guangzhou Institutes of Biomedicine and Health (GIBH) of Chinese Academy of Sciences published a paper entitled "Redox-Modulated SNX25 as a Novel Regulator of GPCR-G Protein Signaling from Endosomes" in Redox B...G Protein-Coupled Receptors (GPCRs) were traditionally believed to be activated solely on the plasma membrane, becoming desensitized post-internalization. However, increasing evidence suggestes that some internalized GPCRs retain their a... -
May 15, 2024Mitochondrial DNA-encoded 14th Protein Discovered from Cytosolic TranslationMitochondria are multifunctional organelles that provide energy for multiple cellular activities, but are also indispensable for apoptosis regulation, cell signaling and many biosynthetic pathways. Many of these functions entail the re...