HomePrincipal Investigator
Principal Investigator
Principal Investigator
Name：Guangjin Pan
Professional：Principle Investigator
Email：pan_guangjin@gibh.ac.cn
Address：No.190 Kaiyuan Road, Guangzhou Science Park, Luogang District, Guangzhou 510530
Study/Work Experience

2010.06–now

Guangzhou Institutes of Biomedicine and Health (CAS)/Principal Investigator,Deputy Director General  

2008.10–2010.06

University of Wisconsin-Madison/

Assistant Scientist

2005.10–2008.10

University of Wisconsin-Madison/

Post-doc Fellow

2002.09–2005.07

Tsinghua University/Doctoral student

1999.09–2002.07

Shandong Academy of Medical Science/ Postgraduate student

1994.09–1998.07

Shandong University/Bachelor's degree


Research Areas
The research in Pan’s laboratory focuses on three parts mainly: 1. To understand the mechanisms by which control the cell fate maintenance and transition of hPSCs. Using hPSCs as a model, the lab analyzes how different biological processes such as transcription factors mediated expression profile, signaling pathway, epigenetic change involved in the regulation of cell fate transition; 2. To generate functional neural stem cells (NSC) and hematopoietic stem/progenitor cells (HSC/HPC) from hPSCs. Trying to gain functional HPC and reveal the mechanisms involved in differentiation regulation through an integrated approach using molecular biology, cell biology, epigenetics, genomics, FACS, confocal microscopy and so on. For the hPSCs derived NSCs, after the NSCs are tested for their therapeutic potential in animal models, the final goal of this research is to translate the technology to the re-building of the injured or diseased human brain.
Academic Performance

1) Systematically analyzed the roles of PRC2 complex and H3K27me3 in maintaining PSC pluripotency and later fate decision during their differentiation to three germ layers. 2) Revealed the roles of TGFb in shaping the final cell fate during reprogramming of human urine cell(HUC) and developed an efficient approach to generate either neural progenitor cells(NPCs) or iPSCs from HUCs. 3)Developed highly efficient approach to correct genetic mutations in patient iPSCs and analyzed genome stability during iPSC generation and gene targeting. These findings had been published in 34 peer-reviewed papers in journals such as Nat Methods, including 19 of them were published as corresponding or co- corresponding author. Dr. Pan won the second class of “National Natural Science Awards”2013.

Representative Papers

1. Ke Huang, Yanling Zhu, Yanlin Ma,……,Guangjin Pan*. BMI1 enables interspecies chimerism with human pluripotent stem cells. Nature Communications. 2018 Nov; 9:4649

2.Yongli Shan, Zhechuan Liang,……,Guangjin Pan*. PRC2 specifies ectoderm lineages and maintains pluripotency in primed but not naive ESCs. Nature Communications. 2017 Sep; 8:672

3. Ke Huang, Jiao Gao,……,Guangjin Pan*. Generation and analysis of GATA2w/eGFP 2 human ESCs reveal ITGB3/CD61 as a reliable marker for defining hemogenic endothelial cells during hematopoiesis. Stem Cell Reports.2016 Nov; 7(5): 854-868

4. Lihui Wang,……,Guangjin Pan*. TGFβ signaling regulates the choice between pluripotent and neural fates during reprogramming of human urine derived cells. Scientific Reports. 2016 Mar; 6: 22484

5. Lihui Wang, Linli Wang,……, Guangjin Pan*, Duanqing Pei*. Generation of integration-free neural progenitor cells from cells in human urine. Nature Methods. 2013 Jan; 10(1):84-89