Miguel A. Esteban--Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences

Principal Investigator

Name：Miguel A. Esteban

Professional：Principle Investigator

Email：miguel@gibh.ac.cn

Address：No.190 Kaiyuan Road, Guangzhou Science Park, Luogang District, Guangzhou 510530

Study/Work Experience

2008–now	Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Principal Investigator
2004 – 2007	Renal research laboratory, department of Medicine, Imperial College London(group leader: Professor Patrick H. Maxwell)/ Postdoctoralresearch associate
1999–2004	University Autonoma de Madrid/Ph.D
1995–1999	Department of Immunology, Hospital de la Princesa, Madrid (Spain)/ Postgraduate degree in Clinical Immunology, resident doctor
1999–2003	University of Navarra, Pamplona (Spain)/ Bachelor in Medicine and Surgery

Research Areas

Immunology (special emphasis on inflammation), Cancer Biology (in particular related to hypoxia and oxygen sensing), genetic syndromes, Stem Cell Biology (in particular related to induced pluripotent stem cells and embryonic stem cells), Linc-RNAs

Academic Performance

Miguel A. Esteban graduated in Medicine and Surgery from University of Navarra in Spain. He then obtained his medical specialization degree in Clinical Immunology from Hospital de la Princesa (Madrid, Spain) and his PhD in Biochemistry and Molecular Biology from University Autonoma (Madrid, Spain). He moved to the Imperial College London lab of Patrick Maxwell, where he studied tumor cell responses to reduced oxygenation, before arriving in China in 2008 to initiate his own lab at the Guangzhou Institutes of Biomedicine and Health. He was selected the first non-Chinese origin scientist leading the 973 program of the Ministry of Science and Technology of China in 2010, and in 2018 obtained the Outstanding Science and Technology Award of the Chinese Academy of Sciences for his contribution to the discovery of the role of vitamin C and the mesenchymal-to-epithelial transition in somatic cell reprogramming. In 2018, he also received the Innovation Award from the Chinese Society for Stem Cell Research for his work on RNA biology and stem cells, and was made Honorary Citizen of Guangzhou. Miguel’s lab focuses on understanding stem cell function to improve in vivo and in vitro applications.

Representative Papers

1.Zhuang Q, Li W, Benda C,……,Hutchins AP*, Esteban MA*. NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming. Nat Cell Biol. 2018 Apr;20(4):400-412

2. Bao X*, Guo X, Yin M, Tariq M, ……, Zhang B*, Esteban MA*. Capturing the interactome of newly transcribed RNA.Nature Methods. 2018 Mar;15(3):213-220

3. Jiayin Yang, Yu Wang, Ting Zhou,……,Miguel A. Esteban*, Hung-Fat Tse*. Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Mar;8(3):605-618

4. Bao X*, Wu H, Zhu X, ……,Zhang B, Esteban MA*. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Research. 2015 Jan;25(1):80-92

5. Liu L, Xu Y*, He M, ……Esteban MA*. Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming. Cell Stem Cell.2014 Nov;15(5):574-88