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 Dr. Xingguo Liu, Professor in Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Science. He was honored as“Outstanding Youth Foundation” of NSFC, “Yangtse River Scholar” Bonus Schemes, “One Hundred Talents Program” of Chinese Academy of Sciences, Natural Science Funds for “Distinguished Young Scientists” of Guangdong, “Science and Technology Innovation Leading Talents” of Guangdong, “Science and Technology Innovation Young Talents” of Guangdong, “2016 Stem cell Young Investigator Award” from Chinese Society for Cell Biology and “2011 Young Bioenergeticist Award” of Biophysical Society (only one per year). He is the editor of 8 international journals. Dr. Liu has 21 papers as 1st or corresponding author on international journals (Total impact factor more than 130), including 9 papers as sole corresponding author such as Cell Metabolism、Hepatology、Autophagy. His many papers were recommended by F1000, and highest citation of his paper is more than 150. He has applied or obtained 9 patents, among which one is PCT patent.  Dr. Liu’s group has been focusing on mitochondrial and metabolic remodeling in cell fate determination, and mechanisms of mitochondrial diseases and therapy by stem cells.

Position

Professor, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences         2010-present

Research fellow, Thomas Jefferson University                                              2007-2010

Education

Tsinghua University                       Ph.D. (Biology)                            2002-2006

Shandong University                            Bachelor (Biotechnology)                            1998-2002

Awards and  honors

2016    National Natural Science Foundation—“Outstanding Youth Foundation” of China

2016   “Yangtse River Scholar” Bonus Schemes

2016    “Stem cell Young Investigator Award” from Chinese Society for Cell Biology

2015     “Science and Technology Innovation Leading Talents” of Guangdong

2014     “Science and Technology Innovation Young Talents” of Guangdong

2012    Natural Science Funds for “Distinguished Young Scientists” of Guangdong

2011      “One Hundred Talents Program” of Chinese Academy of Sciences, and selectively supported

2011    Biophysical Society “2011 Young Bioenergeticist Award” (One per year), “In recognition of your contribution and potential for leadship in the field of Bioenergetics

 

Editorial Activities

2011-now, Editor of 8 international journals such as Frontiers in Genetics of Aging

 

Research: 
The directions of our lab are: 
(1) Organelle remodeling and metabolic controlling in cell fate determination
(2) Mechanisms of mitochondrial diseases and therapy by stem cells

 

Publications

1.       Ying, Z., Chen K., Zheng L., …&  Liu, X*. (2016). Transient activation of mitoflashes modulates Nanog at the early phase of somatic cell reprogramming. Cell Metabolism, 23(1): 220-226.

2.       Li, S., Guo, J., Ying, Z., ... & Liu, X*. (2015). Valproic acidinduced hepatotoxicity in alpers syndrome is associated with mitochondrial permeability transition pore openingdependent apoptotic sensitivity in an induced pluripotent stem cell model. Hepatology, 61(5), 1730-1739.

3.       Xiang, G., Yang, L., Long, Q., …& Liu, X*. (2017). BNIP3L-dependent Mitophagy Accounts for Mitochondrial Clearance during SKO-induced Somatic Cell Reprogramming. Autophagy, 2017 Jul 19:1-13. doi: 10.1080/15548627.2017.1338545.

4.       Chen, K., Long, Q., Wang, T., … Liu, X* & Pei, D*. (2016) FRAP screening identifies Gadd45a as a heterochromatin relaxer that enhances iPSC generation. EMBO Reports,17(11), 1641-1656. (co-corresponding author)

5.       Li, L., Chen, K., Wu Y.,...& Liu, X*. (2017). Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. Cell Death & Disease, (In press).

6.       Wu, Y., Chen, K., Liu, X., ... & Liu, X*. (2015). Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming. Stem Cells, 34(1): 83-92.

7.       Yang, L., Long, Q., Liu, J., ... & Liu, X*. (2015). Mitochondrial fusion provides an ‘initial metabolic complementation’ controlled by mtDNA. Cellular and Molecular Life Sciences, 72(13):2585-2598.

8.       Long, Q., Zhao, D., Fan, W., ... Wang X* & Liu, X*. (2015). Modeling of Mitochondrial Donut Formation. Biophysical Journal, 109(5), 892-899. (co-corresponding author)

9.       Bao, F., Shi, H., Long, Q., …& Liu, X*. (2016). Mitochondrial Membrane Potential-dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration. CNS Neuroscience & Therapeutics, 22(8), 648-660. (Cover Story)

10.   Liu, W., Long, Q., Chen, K., ... & Liu, X*. (2013). Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation. Biochemical and Biophysical Research Communications, 431(4), 767-771.

11.   Liu, X., Weaver, D., Shirihai, O., & Hajnóczky, G. (2009). Mitochondrial ‘kissandrun’: interplay between mitochondrial motility and fusion–fission dynamics. The EMBO Journal, 28(20), 3074-3089. (F1000 recommendation)

12.   Liu, X., & Hajnoczky, G. (2011). Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia–reoxygenation stress. Cell Death & Differentiation, 18(10), 1561-1572. (F1000 recommendation)

13.   Weaver, D., Eisner, V., Liu, X., … & Hajnóczky, G. (2014). Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. Molecular Cell, 54(5), 870-878. (co-first author)

14.   Liu, X., & Hajnóczky, G. (2009). Ca2+-dependent regulation of mitochondrial dynamics by the Miro–Milton complex. The International Journal of Biochemistry & Cell Biology, 41(10), 1972-1976.

15.   Twig, G., Liu, X., Liesa, M., ... & Shirihai, O. S. (2010). Biophysical properties of mitochondrial fusion events in pancreatic β-cells and cardiac cells unravel potential control mechanisms of its selectivity. American Journal of Physiology-Cell Physiology, 299(2), C477-C487. (co-first author)

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