Metabolism and cell fate: how metabolism regulates stem cell self-renewal and pluripotency, and whether these mechanisms play similar important roles in vivo and during stem cell aging.

He has published >20 papers in journals such as Cell Stem Cell, Nature Cell Biology, Cell Research and Journal of Biological Chemistry. Got 3 patents. 2016, Leading scientist of National Key Research Plan-Stem Cell and Translational Research Program; 2013, “National Natural and Science Awards” second prize; 2016, Guangdong Special Talent Supporting Program; 2017, Outstanding Awards of CAS-major participant; 2010-2011, Excellent PhD thesis, Excellent Dean Awards, Excellent Graduate of CAS.

Major scientific contributions:

1. discovered first vitamin C (Vc) enhances greatly somatic cell reprogramming and opened a new direction to understand the biological roles of Vc (Cell Stem Cell, cover story, 2010, >800 citations); further characterized the roles of autophagy and mTORC1 in regulating mitochondrial and cellular remodeling in early stage of somatic cell reprogramming (Nature Cell Biology, 2015).

2. reported first the unique DNA mutation pattern of Chinese non-small cell cancer patients which provided important clues for targeted chemical therapy development (Cell Research, 2005).

1. Yasong Wu,……, Baoming Qin*, Duanqing Pei*. Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nature Cell Biology.2015 Jun;17(6):715-725

2. Xichen Bao, Xihua Zhu, ……, Baoming Qin*, Miguel Angel Esteban*. MicroRNAs in somatic cell reprogramming. Current Opinion in Cell Biology 2013 Apr;25(2):208-214

3. Miguel Angel Esteban#, Tao Wang#, Baoming Qin#, ……, Duanqing Pei*. (2010) Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. Cell Stem Cell. 2010 Jan;6(1):71-79

4. Baoming Qin, Miao He, Xiao Chen, Duanqing Pei*.Sorting Nexin 10 Induces Giant Vacuoles in Mammalian Cells. Journal of Biological Chemistry. 2006 Dec;281(48):36891-36896

5. Baoming Qin, Xiao Chen, Jingde Zhu, Duanqing Pei*. Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy. Cell Research. 2005 Mar;15(3):212-217