People
CAI Chenleng
Title：Principle Investigator
Subject：
Email：cai_chenleng@gibh.ac.cn
Address：Kaiyuan Dadao 190,510530,Guangzhou,China
Study/Work Experience
Research Areas

Patens

1.Sylvia M Evans, Ju Chen, Chen-Leng Cai, Alessandra Moretti, Kenneth R Chien, Karl-Ludwig Laugwitz, Use of islet 1 as a marker for isolating or generating stem cells. United States Patent 7745113.

2.Sylvia Evans, Ju Chen, Chen-Leng Cai, Wenlai Zhou, Michael G Rosenfeld,  Compositions and methods for treating diseases associated with T-box and N-Myc. US Patent 7981615.


Academic Performance

1. 2015-2018  Grant-in-Aid, American Heart Association

2. 2009-2014  Independent Scientist Award, NIH

3. 2008-2011  Grant-in-Aid, American Heart Association

4. 2008-2010  Basil O'Connor Starter Scholar, March of Dimes

5. 2004-2008  National Scientist Development Award, American Heart Association

6. 2004           Schuman Award, University of California, San Diego

7. 2001-2003  Postdoctoral Fellowship, American Heart Association

8. 1997           Blue Moon Prize, Wuhan University


Representative Papers

1. Zhang L, Sultana N, Yan J, Yang F, Chen F, Chepurko E, Yang FC, Du Q, Zangi L, Xu M, Bu L,Cai CL*.Cardiac Sca-1+ cells are not intrinsic stem cells for myocardial development, renewal and repair.Circulation.2018;138:2919–2930.

2. Cai CL*, Molkentin JD*. The Elusive Progenitor Cell in Cardiac Regeneration: Slip Slidin' Away. Circulation Research. 2017;120(2):400-406.

3. Sultana N, Zhang L, Yan J, Chen J, Cai W, Razzaque S, Jeong D, Sheng W, Bu L, Xu M, Huang GY, Hajjar RJ, Zhou B, Moon A, Cai CL*. Resident c-Kit+ cells in the heart are not cardiac stem cells. Nature Communication. 2015;6:8701.

4. Zhang L, Nomura-Kitabayashi A, Sultana N, Cai W, Cai X, Moon AM, Cai CL*. Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development. Developmental Biology. 2014 Jun 1;390(1):68-79.

5. Cai X, Zhang W, Hu J, Zhang L, Sultana N, Wu B, Cai W, Zhou B, Cai CL*. Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis. Development. 2013 Aug;140(15):3176-87.

6. Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, Evans SM*. A myocardial lineage derives from Tbx18 epicardial cells. Nature. 2008;454(7200):104-108.

7. Cai CL, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, Evans S*. Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Developmental Cell. 2003;5(6):877-889