People
PENG Guangdun
Title:Principle Investigator
Subject:
Email:peng_guangdun@gibh.ac.cn
Address:Kaiyuan Dadao 190,510530,Guangzhou,China
Study/Work Experience

2018 – now

Guangzhou Institutes of Biomedicine and Health, CAS/ Principal Investigator

2016 – 2018

Shanghai Institute of Biochemistry and Cell Biology, CAS/Associate Professor

2011 – 2016

Shanghai Institute of Biochemistry and Cell Biology, CAS/Assistant Professor

2009 – 2011

University of California, Los Angeles/ Postdoc

2002 – 2009

Shanghai Institute of Biochemistry and Cell Biology, CAS/Ph.D

Research Areas
Implementing cutting-edge technologies to investigate the fundamental mechanisms of stem cell lineage segregation and promoting the translational application of functional stem cells.
Academic Performance
1. characterized the dual progenitor residing the lung epithelium by single cell RNA sequencing (Nature Genetics, 2018);

2. used single-cell sequencing technology to unveil the developmental trajectory and lineage determination of embryonic stem cells during germ layer formation, conducted temporal and spatial transcriptome analysis for in vivo stem cell differentiation and built a positioning reference system for pluripotent stem cells (Developmental Cell, 2016), which enables positional mapping of single cells to the embryonic architecture, facilitating the identification of stem cell identity and differentiating potential;

3. established an integrated platform for automatic single-cell RNA sequencing and spatial transcriptome to decipher the lineage specification of pluripotent stem cells (Nature Protocols, 2017).

4. published 30+ scientific articles or reviews in stem cell and embryonic development, attracted >600 citations.

Representative Papers

2018-2024

 

1. Fan Y, Bian X, Meng X, Li L, Fu L, Zhang Y, Wang L, Zhang Y, Gao D, Guo X, Lammi MJ, Peng G* & Sun S* (2024) Unveiling inflammatory and prehypertrophic cell populations as key contributors to knee cartilage degeneration in osteoarthritis using multi-omics data integration. Ann Rheum Dis IF27

2. Qu F, Li W, Xu J, Zhang R, Ke J, Ren X, Meng X, Qin L, Zhang J, Lu F, Zhou X, Luo X, Zhang Z, Wang M, Wu G, Pei D, Chen J, Cui G*, Suo S*, Peng G* (2023) Three-dimensional molecular architecture of mouse organogenesis. Nat Commun, 14: 4599

3. Jiang F, Zhou X, Qian Y, Zhu M, Wang L, Li Z, Shen Q, Wang M, Qu F, Cui G, Chen K, Peng G* (2023) Simultaneous profiling of spatial gene expression and chromatin accessibility during mouse brain development. Nat Methods, 20: 1048–1057

4. Xu HJ, Yao Y, Yao F, Chen J, Li M, Yang X, Li S, Lu F, Hu P, He S*, Peng G*, Jing N* (2023) Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells. Cell Regen, 12: 15

5. Meng X, Cui G, Peng G* (2023) Lung development and regeneration: newly defined cell types and progenitor status. Cell Regen, 12: 5

6. Chen C, Liao Y, Peng G* (2022) Connecting past and present: single-cell lineage tracing. Protein Cell

7. Cui G, Feng S, Yan Y, Wang L, He X, Li X, Duan Y, Chen J, Tang K, Zheng P, Tam PPL, Si W*, Jing N*, Peng G* (2022) Spatial molecular anatomy of germ layers in the gastrulating cynomolgus monkey embryo. Cell Rep, 40: 111285

8. Wen L, Li G, Huang T, Geng W, Pei H, Yang J, Zhu M, Zhang P, Hou R, Tian G, Su W, Chen J, Zhang D, Zhu P, Zhang W, Zhang X, Zhang N, Zhao Y, Cao X*, Peng G*, Ren X*, Jiang N*, Tian C*, Chen ZJ* (2022) Single-cell technologies: From research to application. Innovation (Camb), 3: 100342

9. Li Z, Peng G (2021) Spatial transcriptomics: new dimension of understanding biological complexity. Biophysics Reports, 7: 1–17

10. Xia Q, Cui G, Fan Y, Wang X, Hu G, Wang L, Luo X, Yang L, Cai Q, Xu K, Guo W, Gao M, Li Y, Wu J, Li W, Chen J, Qi H, Peng G*, Yao H* (2021) RNA helicase DDX5 acts as a critical regulator for survival of neonatal mouse gonocytes. Cell Prolif, 54: e13000

11. Lin J, Wu S, Shen Q, Liu J, Huang S, Peng G*, Qiao Y* (2021) Base editing-mediated perturbation of endogenous PKM1/2 splicing facilitates isoform-specific functional analysis in vitro and in vivo. Cell Prolif, e13096

12. Peng, G.*, Cui, G., Ke, J. and Jing, N. (2020) Using Single-Cell and Spatial Transcriptomes to Understand Stem Cell Lineage Specification During Early Embryo Development. Annu Rev Genomics Hum Genet 2020; 21 163-181.

13. Peng G#*, Suo S#, Cui G#, Yu F#, Wang R, Chen J, Chen S, Liu Z, Chen G, Qian Y, Tam PPL, Han JJ*, Jing N* (2019) Molecular architecture of lineage allocation and tissue organization in early mouse embryo. Nature, 572: 528–532 

14. Liu Q, Liu K, Cui G, Huang X, Yao S, Guo W, Qin Z, Li Y, Yang R, Pu W, Zhang L, He L, Zhao H, Yu W, Tang M, Tian X, Cai D, Nie Y, Hu S, Ren T, Qiao Z, Huang H, Zeng YA, Jing N, Peng G*, Ji H*, Zhou B* (2019) Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction. Nat Genet, 51: 728–738

15. Cui, G., Jing, N. and Peng, G.* (2019) Comments on ‘Molecular architecture of lineage allocation and tissue organization in early mouse embryo’. J Mol Cell Biol 11, 1024-1025.

16. Peng G, Han JJ (2018) Regulatory network characterization in development: challenges and opportunities. F1000Res, 7:

17. Cui G, Suo S, Wang R, Qian Y, Han JJ*, Peng G*, Tam PPL*, Jing N* (2018) Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning. Dev Growth Differ, 60: 463–472

18. Han X#, Luo S#, Peng G#, Lu JY, Cui G, Liu L, Yan P, Yin Y, Liu W, Wang R, Zhang J, Ai S, Chang Z, Na J, He A, Jing N, Shen X (2018) Mouse knockout models reveal largely dispensable but context-dependent functions of lncRNAs during development. J Mol Cell Biol, 10: 175–178

 

2016-2018

 

19. Peng G (2017) Looking Back: Single-Cell Analysis Empowering Stem Cell Studies (2017) Cell Stem Cell 20: 758 (Commentary)

20. Peng G, Tam PPL, Jing N (2017) Lineage specification of early embryos and embryonic stem cells at the dawn of enabling technologies. National Science Review, 4: 533–542

21. Peng G*, Jing N* (2017) The genome-wide molecular regulation of mouse gastrulation embryo. Sci China Life Sci, 60: 363–369

22. Chen J#, Suo S#, Tam PP, Han JJ, Peng G*, Jing N* (2017) Spatial transcriptomic analysis of cryosectioned tissue samples with Geo-seq. Nat Protoc, 12: 566–580

23. Peng G#, Suo S#, Chen J#, Chen W, Liu C, Yu F, Wang R, Chen S, Sun N, Cui G, Song L, Tam PP, Han JD*, Jing N* (2016) Spatial transcriptome for the molecular annotation of lineage fates and cell identity in mid-gastrula mouse embryo. Dev Cell, 36: 681–697

 

(*: corresponding author; #: first author)

 

完整论文情况Google scholar: https://scholar.google.com/citations?user=s7XddBgAAAAJ