People
ZHU Qiang
Title：Principle Investigator
Subject：
Email：zhu_qiang@gibh.ac.cn
Address：No.190 Kaiyuan Road, Guangzhou Science Park, Luogang District, Guangzhou 510530
Study/Work Experience

2008.05 – now

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences/ Principle Investigator

2005.09 – 2008.02

XTL Biopharmaceuticals Inc./staff scientist

2001.04 – 2005.09

Vivoquest, Inc./staff scientist

2000.08 – 2001.04

Colorado State University/Postdoc

1995.09 – 2000.06

Shanghai Institutes of Organic Chemistry, Chinese Academy of Sciences/Ph.D

1991.09 – 1995.06

Nanjing University/B.S

Research Areas

Prof. Zhu has been a principal investigator and academic leader at the Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, since 2008. In 2011, he was honored with the "Hundred Talent Program" award from the Chinese Academy of Sciences. With eight years of postdoctoral and drug development experience in the United States, he returned to China and has since focused on the novel and efficient synthesis methodologies for heterocycles and the development of antibacterial drugs, achieving numerous innovative breakthroughs.

In recognition of his contributions, he received the second prize for the Guangzhou Science and Technology Progress Award (as the first completer) in 2015 and the third prize for the Guangdong Science and Technology Award (also as the first completer) in 2016. To date, he has published over 80 articles independently in high-quality international SCI journals and has applied for five Chinese patents. He currently chairs ten projects funded by the National Natural Science Foundation of China, as well as by the Natural Science Foundations of Guangdong and Guangzhou.

Prof. Zhu has been recognized as an "Outstanding Postgraduate Tutor" at the Guangzhou education base of the Chinese Academy of Sciences in both 2012 and 2016, and he received the "Outstanding Postgraduate Tutor" award from the Chinese Academy of Sciences in 2012.

Patents

1. Qonghai Wu, Qiang Zhu, Song Yang, Lanying Liu, Changlan Peng.

The new applications of artemisinin derivatives. Chinese patent No. ZL201010216620.0

2. Qiang Zhu, Honggen Wang, Yong Wang, Dongdong Liang, Lanying Liu, Jiancun Zhang.

New synthetic methods for imidazo[1,2-a]pyridine and imidazole aldehyde compounds. Chinese patent No. 201110251560.0

3. Qiang Zhu, Tianyu Zhang, Lanying Liu, Minghui Lu, Tingting Mao, Jinbo Huang.

Preparation methods and applications of indole[3,2-c]quinoline compounds or their pharmaceutically acceptable salts. Chinese patent No. 201310385431.X

4. Zhengchao Tu, Qiang Zhu, Tianyu Zhang, Jinbo Huang, Xiaobing Xu, Junting Wan, Mingke Li, Dengke Li, Yali Zhou, ZHiyong Liu, Bangxing Wang, Miqui Totrella.

Indole-2-one-3-spirothiazine or thiazolone compounds and their applications. Chinese patent No. CN201610657161.7

5. Qiang Zhu, Yu Luo, Shuang Luo, Xilong Wang, Yan Peng, Chaoqin Wang.

Chiral dibenz[e,g][1,4]diazocine ligands and their preparation methods. Chinese patent No. 202110022559.4


Academic Performance

1. the second prize for the Guangzhou Science and Technology Progress Award (2015)

2. the third prize for the Guangdong Science and Technology Award (2016)

3. Hundred Talent Program of CAS

4. Outstanding Postgraduate Tutor of CAS (2012, 2016)


Representative Papers

1.  Sidi Cheng, Ting Yu, Jing Li*, Yingxiang Liang, Shuang Luo* and Qiang Zhu*, Copper/ Chiral Phosphoric Acid-Catalyzed Intramolecular Reduc-tive Isocyanide-Alkene (1+2) Cycloaddition: Enantioselective Construction of 2-Azabicyclo[3.1.0]hexanes. J. Am. Chem. Soc, 2024, 146, 7956–7962.

2.  Xilong Wang, Chaoqin Wang, Yu Luo,* Jing Li, Chunfang Gan, Shuang Luo, and Qiang Zhu*, Enantioselective synthesis of inherently chiral 9-benzylidene-9H-tribenzo[a,c,e][7]annulene and its application as a ligand platform. Chem. Catal., 2024, 5,100904.

3.  Ting Yu, Sidi Cheng, Yu Luo, Jing Li, Yingxiang Liang, Shuang Luo*, and Qiang Zhu*, Immobilizing Stereogenic Nitrogen Center in Doubly Fused Triarylamines through Palladium-Catalyzed Asymmetric C-H Activation/Seven-Membered-Ring Formation. ACS Catal., 2023, 13, 9688–9694.

4.  Yu Luo, Xilong Wang, Weiming Hu, Yan Peng, Chaoqin Wang, Ting Yu, Sidi Cheng, Jing Li, Yimiao He, Chunfang Gan, Shuang Luo* and Qiang Zhu*, Inherently Chiral 6,7-Diphenyldibenzo[e,g][1,4]diazocine: Enantioselective Synthesis and Application as a Ligand Platform. CCS Chem., 2023, 5, 982-993.

5.  Xilong Wang, Yu Luo, Jing Li, Chaoqin Wang, Qianwen Liu, Yimiao He, Shuang Luo* and Qiang Zhu*, Parallel Kinetic Resolution through Palladium-Catalyzed Enantioselective Cycloimidoylation: En Route to Divergent N-Heterocycles Bearing a Quaternary Stereogenic Center. ACS Catal., 2022, 12, 14918-14925.

6.  Fan Teng, Ting Yu, Yan Peng, Weiming Hu, Huaanzi Hu, Yimiao He, Shuang Luo* and Qiang Zhu*, Palladium-Catalyzed Atroposelective Coupling-Cyclization of 2-Isocyanobenzamides to Construct Axially Chiral 2-Aryl- and 2,3-Diarylquinazolinones. J. Am. Chem. Soc., 2021, 143, 2722-2728.

7.  Huaanzi Hu, Fan Teng, Jian Liu, Weiming Hu, Shuang Luo* and Qiang Zhu*, Enantioselective Synthesis of 2-Oxindole Spirofused Lactones and Lactams by Heck/Carbonylative Cylization Sequences: Method Development and Applications. Angew. Chem. Int. Ed., 2019, 58, 9225-9229.